Recurrent acute pancreatitis: is it possible to exclude chronic pancreatitis?

Takeyama, Yoshifumi

doi:10.1007/s00535-006-1866-2

Cited by 2 publications

(2 citation statements)

References 13 publications

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“…Acute pancreatitis (AP), as a common digestive disorder, has different clinical outcomes, some of which develop into recurrent acute pancreatitis (RAP). [ 1 ] Epidemiological studies have shown that the incidence rate of RAP varies from 11% to 32% in AP patients,[ 2 3 ] some of which may develop chronic pancreatitis, resulting in a reduction in physical and mental components of quality of life and an increase in socioeconomic burden. [ 4 ]…”

Section: Introductionmentioning

confidence: 99%

Different clinical characteristics between recurrent and non-recurrent acute pancreatitis

Ding¹,

Song²,

Guo³

et al. 2022

Saudi Journal of Gastroenterology

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Background: Acute pancreatitis (AP) is a common digestive disorder with different clinical outcomes, some of which develop into recurrent acute pancreatitis (RAP). This study aimed to explore the differences between AP and RAP. Methods: All patients with AP admitted to Changsha Central Hospital between January 2015 and December 2020 were included. Characteristics between RAP and non-RAP groups were compared. Independent factors associated with RAP were identified by multivariate logistic regression analyses. Results: This was a retrospective study. A total of 1567 patients, including 262 patients in the RAP group and 1305 patients in the non-RAP group, were enrolled. Compared to the non-RAP group, results indicated that the RAP group was younger ( P < 0.001), had a male predominance ( P < 0.001), and had higher incidences of diabetes ( P < 0.001) and hypertriglyceridemia (HTG) ( P < 0.001). Lower incidences of cholelithiasis ( P < 0.001) and acute liver injury ( P < 0.001) were also noted in the RAP group. Scores of Ranson, BISAP, SOFA, and APACHE II were significantly higher in the non-RAP group ( P < 0.001 for all). Three independent factors associated with RAP, including male gender ( P = 0.006), diabetes ( P < 0.001), and HTG ( P < 0.001), were identified by multivariate logistic regression. Conclusion: Compared to the non-RAP, the incidence of cholelithiasis and acute liver injury was lower in RAP. Three independent factors associated with RAP, namely male, diabetes, and HTG, were identified.

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Section: Introductionmentioning

confidence: 99%

Different clinical characteristics between recurrent and non-recurrent acute pancreatitis

Ding¹,

Song²,

Guo³

et al. 2022

Saudi Journal of Gastroenterology

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“…RAP still represents a challenging disease, repeated episodes of which contribute substantially to the overall disease burden by prompting repeated hospitalization, adversely impacting quality of life as well as increasing the risk of progression to chronic pancreatitis and pancreatic tumor [2,[11][12][13][14]. RAP may run a milder clinical course than an index episode [15,16], but the fatality rate of which was signi cantly higher than that of patients with rst-episode AP [17].…”

Section: Discussionmentioning

confidence: 99%

Establishment of a Model for Predicting the Recurrence of Recurrent Acute Pancreatitis in A Short Period of Time

Yang

Liu

et al. 2020

Preprint

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Background Little is known about what factors affect recurrence of recurrent acute pancreatitis (RAP) in a short-term. We performed a retrospective study of patients with RAP, and used non-invasive and quantitative biomarkers to establish a predictive model, so as to provide a basis for effectively predicting and preventing recurrence of RAP. MethodsWe performed a retrospective study of 261 RAP patients admitted to Dazhou Central Hospital from January 2008 through December 2018. The short-term group (n=138) and the long-term group (n=123) were compared. Eight clinical patient characteristics and past medical history were collected from admission records. The prediction model was developed by independent risk factors，and the model to predict the effects were confirmed by the area under the ROC cure．ResultsThe study found that β2-microglobulin (β2-MG) (OR, 0.534; 95% CI, 0.329 to 0.866) and C-reactive protein (CRP) (OR, 1.01; 95% CI, 1.002 to 1.017) were the independent predictors of short-term recurrence. Based on these Independent risk factors，a predicted model for short-term recurrence in RAP patients was constructed．The model was L=β2-MG -0.016BCRP. The AUC for model was 0.651 and the optimal cut-off value was 0.7414, with a sensitivity of 65.9%and a specificity of 63.4%.ConclusionsA new biomarker-based model for predicting risk of short-term recurrence in patients with RAP was satisfactorily developed. The model utilizing β2-MG and CRP may assist physicians in patient education and decision-making when preventing from recurrent attacks with RAP.

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Recurrent acute pancreatitis: is it possible to exclude chronic pancreatitis?

Cited by 2 publications

References 13 publications

Different clinical characteristics between recurrent and non-recurrent acute pancreatitis

Different clinical characteristics between recurrent and non-recurrent acute pancreatitis

Establishment of a Model for Predicting the Recurrence of Recurrent Acute Pancreatitis in A Short Period of Time

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