Recurrent antimicrobial exposure and acute psychosis

Ketcham, Evan; Miller, Brian J.

doi:10.12788/acp.0075

Cited by 1 publication

(2 citation statements)

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“…Along this line of thought, IBD and CRC, conditions characterized by increased intestinal permeability and MT appear to validate Kraepelin's migration model [216][217][218]. The same can be stated about psychosis induced by urinary tract infections (UTI), a destabilizing condition in patients with psychiatric illness [219][220][221] (next subsection). Moreover, Kraepelin's paradigm appears to be validated by the link between maternal influenza and offspring with schizophrenia, or childhood viral enteritis, and the development of psychiatric illness later in life [222][223][224][225].…”

Section: Neuropathology As Mtdsmentioning

confidence: 73%

“…In addition, UTIs are often associated with acute psychosis or psychotic decompensation in stable patients with psychiatric illness [239][240][241]. Along this line, a novel study has taken a fresh look at the connection between UTI and psychosis, emphasizing the role of the previously underappreciated bladder microbiome [221,242]. A recent study, found that a large number of UTI patients were hospitalized with new onset psychosis or psychotic decompensation, suggesting a link between psychopathology and uropathogenic bacteria [239][240][241][242].…”

Section: Urinary Tract Microbiome and Mtdsmentioning

confidence: 99%

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Microbial Translocation Disorders: Assigning an Etiology to Idiopathic Illnesses

Sfera

Hazan²,

Klein

et al. 2023

Applied Microbiology

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Gut microbes are immunologically tolerated in the gastrointestinal tract but trigger aggressive immune responses upon translocation across the gut barrier. Although oral tolerance, a physiological process that dampens immune responses to food proteins and commensal microbiota, remains poorly defined, significant progress was made during and after the Human Immunodeficiency Virus epidemic in the 1980s and the discovery of regulatory T cells in 1995. Additional insight was gained after the discoveries of innate lymphoid cells in 2008 and the functional elucidation of mucosal mast cells. Prior to the historical discovery of human pathogens, the etiologies of most human diseases were considered unknown. The same was true about many genetic disorders prior to the Human Genome Project. Here, we hypothesize that many of the remaining idiopathic conditions, including autoimmune, fibroproliferative, and neuropsychiatric diseases as well as some cancers, can be considered microbial translocation disorders triggered by the host immune responses to extraintestinal gut microbes and/or their constituent parts. In addition to microbial translocation, we also discuss potential interventions for intestinal barrier rehabilitation, including antibodies against tumor necrosis factor-like ligand 1A and membrane lipid replacement supplements.

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