Recurrent Aphthous Stomatitis and Atopy

Veller-Fornasa, C; Bezze, G; Rosin, Stefano; Lazzaro, Michela; Tarantello, M; Cipriani, Roberto

doi:10.1080/00015550310014825

Cited by 15 publications

(12 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Despite detailed investigations, RAS still has an unknown etiology and poorly effective management [18,19]. Genetic, immunological and microbial factors may play a role in the pathogenesis of RAS, whereas attacks may be precipitated by local trauma, stress, food intake, some drugs, hormonal changes or vitamin and trace element deficiencies [19].…”

Section: Discussionmentioning

confidence: 99%

Gluten sensitivity enteropathy in patients with recurrent aphthous stomatitis

et al. 2009

View full text Add to dashboard Cite

BackgroundGluten sensitive enteropathy (GSE) is an autoimmune enteropathy triggered by the ingestion of gluten-containing grains in susceptible individuals. Recurrent aphthous stomatitis (RAS) may be the sole manifestation of GSE. The aim of this study was to determine the prevalence of gluten sensitivity enteropathy (GSE) in a large group of patients with RAS and assess the efficacy of gluten free diet (GFD) on the improvement of aphthous lesions in those who were diagnosed with GSE.MethodsTwo hundred and forty seven patients with RAS were included. The patients had at least three aphthous attacks per year. Patients were screened by IgA anti-endomysial antibody (EMA), IgA anti tissue transglutaminase (TTG) and serum IgA level. Those with a positive serology underwent endoscopic biopsies of the duodenal mucosa and patients with negative serology were excluded. The diagnosis of GSE was based on a positive serological test and abnormal duodenal histology. For patients with GSE, gluten free diet was recommended.ResultsSix out of 247 RAS patients had positive TTG test alone, and one had positive EMA and TTG. All 7 patients with positive serologic tests underwent duodenal biopsies. Histological findings were compatible with GSE in all of them (Marsh I in four patients, Marsh II in two patients and Marsh IIIB in one another.). The mean age of GSE patients was 27.42 ± 10.56 (range, 13 to 40) years old. They were suffering from RAS for an average duration of 4.5 years. All of the 7 GSE patients had not responded to the routine anti-aphthae medications, including topical corticosteroids, tetracycline and colchicine. Four patients who adhered to a strict gluten-free diet showed noticeable improvement in their aphthous lesions over a period of 6 months.ConclusionA significant minority (e.g. 2.83%) of RAS patients have GSE. This could be compared with the 0.9% prevalence of GSE in the general population of Iran. This study suggests that evaluation for celiac disease is appropriate in patients with RAS. Additionally, the unresponsiveness to conventional anti-aphthae treatment could be an additional risk indicator.

show abstract

Section: Discussionmentioning

confidence: 99%

Gluten sensitivity enteropathy in patients with recurrent aphthous stomatitis

et al. 2009

View full text Add to dashboard Cite

show abstract

“…However, most patients who suffer from RAS are usually healthy individuals. Factors such as trauma (Scully et al , 2002; Natah et al , 2004), stress (Andrews and Hall, 1990; Scully et al , 2002), family tendency (Scully et al , 2002; Field and Allan, 2003), atopy (Veller‐Fornasa et al , 2003), nutrition (Eversole et al , 1982; Shashy and Ridley, 2000), drug reactions (Heally and Tornhill, 1995; Boulinguez et al , 2000), immune disturbance (Scully et al , 2002), hormonal imbalance (Field and Allan, 2003; Natah et al , 2004), and microbial factors (Scully et al , 2002; Field and Allan, 2003; Jurge et al , 2006), which are thought to be associated with the etiology of RAS, can disturb the equilibrium of oxidant/antioxidant status of the organism and can accelerate the formation of free radicals. Reactive oxygen species (ROS) are the most common free radicals in biologic systems.…”

Section: Introductionmentioning

confidence: 99%

Oxidative stress and myeloperoxidase levels in saliva of patients with recurrent aphthous stomatitis

et al. 2008

View full text Add to dashboard Cite

show abstract

“…Veller‐Fornasa et al . 's study included 46 RAS patients and 45 controls and investigated the clinical signs of atopy, including allergic asthma, rhinitis/conjunctivitis, atopic dermatitis, and urticaria. They noted an atopic background in 80% of the RAS patients and in the families of 58% of these patients.…”

Section: Discussionmentioning

confidence: 99%

“…A slightly higher predominance is observed in females and in individuals of higher socioeconomic status . Although the etiology of RAS is not precisely known, atopic diathesis was reported to be associated with RAS …”

Section: Introductionmentioning

confidence: 98%