Recurrent atrial fibrillation after pulse corticosteroid treatment for a relapse of multiple sclerosis

Pavičić, Tin; Ruška, Berislav; Adamec, Ivan; Habek, Mario

doi:10.1016/j.msard.2019.04.022

Cited by 6 publications

(7 citation statements)

References 12 publications

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“…There have also been case reports of nocturnal sinus bradycardia caused by intravenous methylprednisolone and symptomatic sinus bradycardia after treatment with high-dose oral prednisone in MS patients [114,115]. A recent case report describes a 27-year-old patient who developed atrial fibrillation on two occasions following two consecutive treatments with high-dose methylprednisolone for the treatment of MS relapse and was subsequently discovered to have mild sympathetic autonomic dysfunction [116].…”

Section: Other Ms Drugsmentioning

confidence: 99%

Cardiac Autonomic Dysfunction in Multiple Sclerosis: A Systematic Review of Current Knowledge and Impact of Immunotherapies

Findling

Hauer

Pezawas

et al. 2020

JCM

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Cardiac autonomic dysfunction (CAD) has been reported in patients with multiple sclerosis (MS). This systematic review summarizes the evidence for the types and prevalence of CAD in MS patients, as well as its association with MS type, disease characteristics, fatigue and immunotherapies used to treat MS. The analysis revealed that CAD is correlated with pathophysiological processes of MS, can trigger serious cardiovascular complications that may reduce life expectancy, and may have implications for treatment with immunotherapies, especially fingolimod. Numerous mainly small case-control or cohort studies have reported various measures of CAD (particularly heart rate variation) in MS patients, showing higher rates of abnormality versus controls. A smaller number of studies have reported on cardiac autonomic symptoms in MS, including orthostatic intolerance/dizziness in around 50% of patients. CAD also appears to be associated with disease duration and to be more common in progressive than relapsing-remitting MS. However, although a substantial evidence base suggests that assessing CAD in people with MS may be important, standardised methods to evaluate CAD in these patients have not yet been established. In addition, no studies have yet looked at whether treating CAD can reduce the burden of MS symptoms, disease activity or the rate of progression.

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Section: Other Ms Drugsmentioning

confidence: 99%

Cardiac Autonomic Dysfunction in Multiple Sclerosis: A Systematic Review of Current Knowledge and Impact of Immunotherapies

Findling

Hauer

Pezawas

et al. 2020

JCM

View full text Add to dashboard Cite

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“…kardiotoksičnost visoke doze metilprednizolona kod bolesnika sa hroničnom limfocitnom leukemijomprikaz slučaja cardiotoxicity of high-dose methylprednisolone in patients with chronic lymphocytic leukemiaa case report Several cases of atrial fibrillation developing after high-dose corticosteroid treatment have been described in literature [10,11,13,[19][20][21][22]. A study by van der Hooft et al has shown that the application of high doses of corticosteroids is connected with increased risk of atrial fibrillation development [18].…”

Section: Discussionmentioning

confidence: 99%

“…Reports of atrial fibrillation occurring during or soon after IV administration of HDMP [11] or within 24 -48 hours of the completion of HDMP therapy [5, 21,22] can be found in literature. Also, several published cases have shown that the occurrence of atrial fibrillation was registered within 24 to 48 hours since the completion of HDMP therapy.…”

Section: Discussionmentioning

confidence: 99%

“…U literaturi je opisano da se atrijalna fibrilacija javila tokom ili ubrzo nakon završetka infuzije VDMP-a [11] ili u roku od 24 -48 sati od završetka terapije VDMP-om [5, 21,22]. Takođe, nekoliko objavljenih slučajeva je pokazalo da je pojava atrijalne fibrilacije registrovana u roku od 24 do 48 sati od završetka terapije VDMP-om.…”

Section: Discussionunclassified

“…U literaturi je opisano nekoliko slučajeva atrijalne fibrilacije nakon terapije visokim dozama kortikosteroida [10, 11,13,[19][20][21][22]. Studija van der Hufta i saradnika developed.…”

Section: Diskusijaunclassified

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Cardiotoxicity of high-dose methylprednisolone in patients with chronic lymphocytic leukemia: A case report

Apostolović-Stojanović,

Radojković,

Stojanović

et al. 2022

Srpski medicinski časopis Lekarske komore

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Introduction: Several classes of drugs can cause atrial fibrillation (AF) in patients without heart disease, as well as the occurrence of AF in pre-existing heart disease. Drug-induced AF is most often clinically manifested in the form of paroxysms. High doses of intravenous methylprednisolone (HDMP) in the treatment of chronic lymphocytic leukemia (CLL) have been associated with the occurrence of various adverse effects, including AF. The exact mechanism of HDMP-induced AF is unknown. Case presentation: We present the case of a patient with CLL in whom AF occurred after the administration of a high dose of intravenous methylprednisolone. Conclusion: Physicians should be aware of the special circumstances in the treatment of CLL, because drug-induced AF can be a side effect that limits further therapy.

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Methylprednisolone

2019

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Recurrent atrial fibrillation after pulse corticosteroid treatment for a relapse of multiple sclerosis

Cited by 6 publications

References 12 publications

Cardiac Autonomic Dysfunction in Multiple Sclerosis: A Systematic Review of Current Knowledge and Impact of Immunotherapies

Cardiac Autonomic Dysfunction in Multiple Sclerosis: A Systematic Review of Current Knowledge and Impact of Immunotherapies

Cardiotoxicity of high-dose methylprednisolone in patients with chronic lymphocytic leukemia: A case report

Methylprednisolone

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