Recurrent autoimmune hypophysitis successfully treated with glucocorticoids plus azathioprine: a report of three cases

Yang, Guoqing; Gu, Weijun; Du, Jin; Guo, Qinghua; Xl, Wang; Ba, Jianming; Dou, Jingtao; Mu, Yiming; Lu, Juming

doi:10.1507/endocrj.k10e-334

Cited by 25 publications

(17 citation statements)

References 18 publications

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“…Relapse rate in our series was almost 30 %, and there is no standard management approach for recurrent hypophysitis [48]. Treatment options include additional corticosteroids, other immunosuppressive agents such as azathioprine [49][50][51][52][53][54] or rituximab [55], surgery or radiosurgery [56,57].…”

Section: Discussionmentioning

confidence: 79%

Hypophysitis: a single-center case series

et al. 2014

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Section: Discussionmentioning

confidence: 79%

Hypophysitis: a single-center case series

et al. 2014

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“…Azathioprine was the most frequently used agent (12,22), followed by methotrexate (23). Response rates are reassuring.…”

Section: Discussionmentioning

confidence: 99%

Treatment of Primary Hypophysitis in Germany

Honegger

Buchfelder

Schlaffer

et al. 2015

The Journal of Clinical Endocrinology & Metabolism

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“…Meanwhile, some cases adapt glucocorticoid combined with immunosuppressive therapy. Guo-Qing Yang et al demonstrated that glucocorticoids plus azathioprine is useful for treating recurrent LYH [22]. If the patients have brain compression and visual disturbance, surgery should be considered.…”

Section: Discussionmentioning

confidence: 99%

A Teenager Diagnosed as Lymphocytic Hypophysitis Associated with Systemic Lupus Erythematosus (SLE)

Wang¹

2014

J Blood Disord Transfus

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A 15-year-old female was admitted to our hospital with intermittent fever, cough and sputum for one week, and diagnosed as pneumonia. Because of no clinic remission with antibiotic and antiviral treatment for one week and following with facial erythema, severe anemia, and neutropenia, appropriate screening laboratory examinations showed severe lower complements (C3, C4) and positives autoantibody such as ANA, ds DNA, Anti-Sm etc, Therefore, SLE was diagnosed with muti-organs involved including lungs, blood, liver, kidney, medical peritonitis, and central nervous system presented as irritable and moody. Because the patient complained of dizziness, fatigue, anorexia, hands trembling and showed a very indifferent mood, endocrinological tests were took. The results revealed very low levels of sex hormones, thyroid hormones and serum cortisol, and manifested as hypopituitarism. Magnetic resonance imaging (MRI) of pituitary region demonstrated a mild enlargement of the pituitary stalk. SLE associated with Lymphocytic hypophysitis (LYH) was suspected. And the clinical symptoms and laboratory tests were ameliorated after glucocorticoid treatment (involve twice methylprednisolone (MPIV) pulse therapy and oral 40 mg/d of MPIV) combined with cyclophosphamide therapy. Although, LYH associated with SLE have been reported, a 15-year teenager, as seen in this case, is a rare first presentation of SLE.

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Recurrent autoimmune hypophysitis successfully treated with glucocorticoids plus azathioprine: a report of three cases

Cited by 25 publications

References 18 publications

Hypophysitis: a single-center case series

Hypophysitis: a single-center case series

Treatment of Primary Hypophysitis in Germany

A Teenager Diagnosed as Lymphocytic Hypophysitis Associated with Systemic Lupus Erythematosus (SLE)

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