Recurrent bacterial translocation from gut and sepsis in Head and neck cancer patients and its prevention by probiotics

Gündüz, Mehmet; Murakami, Daichi; Gunduz, Ihsan; Tamagawa, Shunji; Hiraoka, Masanobu; Sugita, Gen; Hotomi, Muneki

doi:10.1016/j.mehy.2018.08.020

Cited by 15 publications

(4 citation statements)

References 20 publications

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“…Similarly, the oral microbiota has emerged as a new area of research focused on exploring microbiota-brain interactions. The oral cavity harbors the second most abundant microbial symbionts after the gastrointestinal tract [ 37 ]. It contains approximately 50–100 billion bacteria and 600 prevalent taxa at the species level, which play a crucial protective role against the colonization of external bacteria that can impact overall health [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

Altered oral microbiota and immune dysfunction in Chinese elderly patients with schizophrenia: a cross-sectional study

Ling,

Cheng,

Liu

et al. 2023

Transl Psychiatry

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Schizophrenia (SZ) is a complex psychiatric neurodevelopmental disorder with uncertain etiology and pathogenesis. Increasing evidence has recognized the key role of the gut microbiota in SZ. However, few studies have investigated the potential link between oral microbiota and SZ. We studied the tongue coating microbiota and inflammatory profiles of 118 elderly SZ patients and 97 age-matched healthy controls using Illumina MiSeq sequencing and multiplex immunoassays, respectively. Reduced α-diversity, along with a significant difference in β-diversity, were observed in patients with SZ. We have identified SZ-associated oral dysbiosis, characterized by increased Streptococcus and Fusobacterium, as well as decreased Prevotella and Veillonella. These differential genera could potentially serve as biomarkers for SZ, either alone or in combination. Additionally, an elevated Streptococcus/Prevotella ratio could indicate oral dysbiosis. These differential genera formed two distinct clusters: Streptococcus-dominated and Prevotella-dominated, which exhibited different correlations with the altered immunological profiles. Furthermore, we also observed disruptions in the inferred microbiota functions in SZ-associated microbiota, particularly in lipid and amino acid metabolism. Our study provides novel insights into the characteristics of tongue coating microbiota and its associations with immunological disturbances in elderly SZ patients, which offer new targets for the diagnosis and treatment of SZ in the elderly.

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Section: Discussionmentioning

confidence: 99%

Altered oral microbiota and immune dysfunction in Chinese elderly patients with schizophrenia: a cross-sectional study

Ling,

Cheng,

Liu

et al. 2023

Transl Psychiatry

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“…О предполагаемой роли кишечника в развитии сепсиса сообщают также V. Stadlbaur с соавторами, полагая, что микробиом кишечника и его барьерная функция изменяются на ранних стадиях сепсиса [15]. M. Gunduz с соавторами сообщают о рецидивирующей бактериальной транслокации из кишечника, приводящей к сепсису у больных с раком головы и шеи, перенесших химиотерапию [16].…”

Section: Discussionunclassified

Translocation of Clostridial Infection as a Complication of Hip Arthroplasty in the Early Postoperative Period: Case Report

Павлов

Шералиев

Kirilina

et al. 2020

Traumatology and Orthopedics of Russia

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Background. Periprosthetic joint infection in the early postoperative period is a severe infectious complication. Its development, as a rule, is associated with the exogenous surgical wound infection, with the iatrogenic factor at the forefront. Clinical case description. A 73-years-old female with left-sided idiopathic 3rd stage hip osteoarthritis and concomitant pathology with a high degree of comorbidity underwent left hip arthroplasty with a cement-fixed “Endoservice” endoprosthesis. In the early postoperative period (4th to 6th days), against the background of chronic calculous cholecystitis exacerbation and gastrointestinal dysfunction, clostridial septicemia developed as a result of bacterial translocation. The timely diagnosis of the endogenous nature of this infection and the targeted antibiotic therapy prevented the surgical wound and endoprosthesis infection. The Harris score for the function of the left hip at discharge was 78 points. Conclusion. The presented clinical case demonstrates the importance of careful preoperative planning, especially in the patient with identifying somatic pathology of infectious nature, the need to detail the organ-specific microbiota as a mandatory procedure, as well as the prevention of periprosthetic joint infection during orthopedic operations, taking into account the data obtained.

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“…Prospectively, new medical instruments and further investigations about the role of the human microbiome in regulating healthy and pathologic conditions could give us a number of fundamental information about the pathophysiologic mechanisms of the sepsis [50,51,52,53,54]. Moreover, both the arising knowledge on antibiotic activity of plant extracts [55,56,57,58,59,60,61,62] and on the immune modulating effect of probiotics will be helpful to develop most rapid and economic protocols for septic patients [63,64,65,66,67,68,69,70,71,72,73].…”

Section: Discussionmentioning

confidence: 99%

Current Issues and Perspectives in Patients with Possible Sepsis at Emergency Departments

et al. 2019

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In the area of Emergency Room (ER), many patients present criteria compatible with a SIRS, but only some of them have an associated infection. The new definition of sepsis by the European Society of Intensive Care Medicine and the Society of Critical Care Medicine (2016), revolutionizes precedent criteria, overcoming the concept of SIRS and clearly distinguishing the infection with the patient’s physiological response from the symptoms of sepsis. Another fundamental change concerns the recognition method: The use of SOFA (Sequential-Sepsis Related-Organ Failure Assessment Score) as reference score for organ damage assessment. Also, the use of the qSOFA is based on the use of three objective parameters: Altered level of consciousness (GCS <15 or AVPU), systolic blood pressure ≤ 100 mmHg, and respiratory rate ≥ 22/min. If patients have at least two of these altered parameters in association with an infection, then there is the suspicion of sepsis. In these patients the risk of death is higher, and it is necessary to implement the appropriate management protocols, indeed the hospital mortality rate of these patients exceeds 40%. Patients with septic shock can be identified by the association of the clinical symptoms of sepsis with persistent hypotension, which requires vasopressors to maintain a MAP of 65 mmHg, and serum lactate levels >18 mg/dL in despite of an adequate volume resuscitation. Then, patient first management is mainly based on: (1) Recognition of the potentially septic patient (sepsis protocol-qSOFA); (2) Laboratory investigations; (3) Empirical antibiotic therapy in patients with sepsis and septic shock. With this in mind, the authors discuss the most important aspects of the sepsis in both adults and infants, and also consider the possible treatment according current guidelines. In addition, the possible role of some nutraceuticals as supportive therapy in septic patient is also discussed.

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Recurrent bacterial translocation from gut and sepsis in Head and neck cancer patients and its prevention by probiotics

Cited by 15 publications

References 20 publications

Altered oral microbiota and immune dysfunction in Chinese elderly patients with schizophrenia: a cross-sectional study

Altered oral microbiota and immune dysfunction in Chinese elderly patients with schizophrenia: a cross-sectional study

Translocation of Clostridial Infection as a Complication of Hip Arthroplasty in the Early Postoperative Period: Case Report

Current Issues and Perspectives in Patients with Possible Sepsis at Emergency Departments

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