Recurrent Bilateral Giant Fibroadenomas of the Breasts

Morris, A. H.; Shaffer, Kitt

doi:10.2484/rcr.v2i3.96

Cited by 5 publications

(4 citation statements)

References 13 publications

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“…Hamartomas are characterized by a mixture of lobules, ducts, adipose tissue, and fibrous stroma [2]. This accurate diagnosis was made on the basis of histologic examination of the excised specimens because other diagnostic methods, such as fine-needle aspiration cytology, lack reliability and accuracy, whereas core needle biopsy would have had a high risk of bleeding in addition to low diagnostic accuracy [12].…”

Section: Discussionmentioning

confidence: 99%

Recurrent giant fibroadenomas with transformation to cystosarcoma phyllodes in a 17-year-old girl: a rare case report from Syria

et al. 2019

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BackgroundFibroadenoma is the most prevalent benign breast lesion that generally affects middle-aged women; it is rare in adolescents and younger children. The transformation into malignancy is not common. However, multiple recurrences of rapidly enlarging fibroadenomas suggest a high possibility of transforming into phyllodes tumors, which are uncommon fibroepithelial lesions that account for 0.3–0.5% of female breast tumors and typically present in premenopausal women.Case presentationWe report a case of a 17-year-old Syrian girl who previously had three episodes of recurrence of multiple rapidly enlarging fibroadenomas in her left breast and underwent three operations for complete resection of the lesions. However, a few months later, she was readmitted with multiple large masses in the same breast, and pathological findings confirmed a surprising combination of multiple fibroadenomas for the fourth time with a malignant phyllodes tumor (cystosarcoma phyllodes). The patient underwent lumpectomies followed by adjuvant radiotherapy. Long-term follow-up was recommended.ConclusionOur patient had an extraordinary number of episodes of recurrence at a young age and a rare combination of malignant and benign lesions in the same breast with multiple recurrences. We present her unique, very challenging case with the aim of highlighting the importance of clinical correlation, detailed diagnosis, and careful follow-up.

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Section: Discussionmentioning

confidence: 99%

Recurrent giant fibroadenomas with transformation to cystosarcoma phyllodes in a 17-year-old girl: a rare case report from Syria

et al. 2019

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“…Surgical enucleation remains the mainstay of treatment of giant fibroadenomas in order to allow previously compressed normal surrounding breast tissue and retain normal function and appearance (4). A submammary incision is preferred to provide excellent cosmesis with minimal risk of recurrence (1,2), as in the current case. Mastectomy is not necessary and no adjuvant treatment is indi-2 J Obstet Gynecol Cancer Res.…”

Section: Discussionmentioning

confidence: 99%

Giant Fibroadenoma of the Breast: A Case Report

Moukit¹,

Kouach²,

Mehdi³

et al. 2017

J Obstet Gynecol Cancer Res

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Introduction: Giant fibroadenomas are an uncommon breast tumor accounting for 0.5% to 2% of all cases of fibroadenomas. Diagnosis is difficult due to the rarity of giant fibroadenomas and the resemblance of its clinical and imaging features with other breast neoplasms, especially phyllodes tumor. Case Presentation: The authors report a rare case of giant fibroadenoma in a 14-year-old South Sudanese female, which was suspected clinically, ultrasonography, and by fine needle aspiration cytology and confirmed by histopathology after total mass excision. Conclusions: Fibroadenomas presenting a very large diameter could be mistaken with malignancy and other benign breast lesions. Fine needle aspiration biopsy and core needle biopsy appears fundamental to evaluate their benign nature. Conservative surgery using sub-mammary incision is the gold standard of treatment with good cosmesis.

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“…5 There are only a handful reports of bilateral giant juvenile fibroadenoma in adolescent females and it is more uncommon in premenarche girls. [6][7][8][9][10][11][12][13][14][15][16][17] Our review focuses on premenarche bilateral giant fibroadenomas; presently due to its rarity there is no data about its population incidence, prevalence and management protocols.…”

Section: Introductionmentioning

confidence: 99%

Premenarche bilateral giant juvenile fibroadenoma of breast: literature review with a case report

Raleng¹,

Anand²,

Kannur

2021

Int Surg J

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Fibroadenoma is a common abnormality which every surgeon has been exposed to, and there are several international guidelines regarding its management. However giant fibroadenomas, especially in the premenarche setting has been a rare occurrence, even for the experienced surgeon. Various reports have shown that we need to treat this condition more aggressively than the normal fibroadenoma, and issues of cosmesis in a developing breast along with the aim to preserve lactation functionality becomes an issue. Since these cases remain a single life time experience for most surgeons, there is a sparsity of treatment protocols even in literature. Through this paper we hope to shed some valuable insight to this rare disorder and help surgeon colleagues, when dealing with similar cases.

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Recurrent Bilateral Giant Fibroadenomas of the Breasts

Cited by 5 publications

References 13 publications

Recurrent giant fibroadenomas with transformation to cystosarcoma phyllodes in a 17-year-old girl: a rare case report from Syria

Recurrent giant fibroadenomas with transformation to cystosarcoma phyllodes in a 17-year-old girl: a rare case report from Syria

Giant Fibroadenoma of the Breast: A Case Report

Premenarche bilateral giant juvenile fibroadenoma of breast: literature review with a case report

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