Recurrent canker in a shire mare

Sherman, Kathleen; Ginn, Pamela E.; Brown, Mathew

doi:10.1016/s0737-0806(96)80138-9

Cited by 4 publications

(5 citation statements)

References 2 publications

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“…Additionally, most horses in the present study were presented with advanced stages of disease, creating a severe bias towards a poorer prognosis. Moreover, a very long follow‐up period (up to 6 years) was used, as Sherman et al . (1996) showed recurrence of disease even after apparently complete clinical resolution.…”

Section: Discussionmentioning

confidence: 99%

“…The aim of the present study was to describe 30 cases of equine proliferative pododermatitis retrospectively and to evaluate the effect of adding 3 weeks of oral administration of prednisolone to a standardised protocol involving superficial debridement and hoof care. Long‐term follow‐up was performed given the potential for recurrence after apparently complete clinical resolution (Sherman et al . 1996).…”

Section: Introductionmentioning

confidence: 99%

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Retrospective study on 30 horses with chronic proliferative pododermatitis (canker)

Oosterlinck

Deneut

Dumoulin

et al. 2011

Equine Veterinary Education

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The medical records of 30 horses (18 Warmbloods, 7 draught horses, 3 other breeds and 2 of unknown origin) with chronic proliferative pododermatitis (canker) were reviewed and long-term outcome was obtained by telephone questionnaire. In 28/30 cases, the owner was the first to discover the problem. The disease was initially recognised as canker in only 5/28 cases, whereas in 10/28 cases a treatment for thrush had been continued for several months before referral. There was a similar prevalence in the fore (41) and hind (44) hooves; 13/30 horses had 4 hooves affected. Treatment consisted of surgical debridement and hoof care. Duration of hospitalisation was significantly decreased in horses receiving oral prednisolone for 3 weeks compared to those without this additional systemic treatment (mean +/- s.d. 24 +/- 5 days, n = 7 vs. 40 +/- 19 days, n = 19, respectively). Long-term follow-up ranged from 3 months to 6 years (36 +/- 22 months) and was available for 24 horses. No recurrence was reported in 10 horses. In 14 horses problems recurred within the first year, and 6 had been subjected to euthanasia for this reason specifically, whereas the others were managed by regular trimming. There was no significant association between recurrence and the number of affected hooves or the use of any systemic treatment. Horses with delayed referral because of preceding treatments had significantly more chance to develop recurrence, highlighting the need for prompt diagnosis and subsequent treatment

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Retrospective study on 30 horses with chronic proliferative pododermatitis (canker)

Oosterlinck

Deneut

Dumoulin

et al. 2011

Equine Veterinary Education

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“…Increased levels of PCNA protein expression and morphological alterations indicate dysregulation of keratinocyte differentiation constitutes a key event in equine hoof canker development. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 3,9,19,20,28 However, for any of these, a causal association with the development of disease remains to be established. Morphological studies of hoof canker tissues are rare.…”

Section: Introductionmentioning

confidence: 99%

“…3, 9,19,20,28 However, for any of these, a causal association with the development of disease remains to be established. Morphological studies of hoof canker tissues are rare.…”

Section: Introductionmentioning

confidence: 99%

“…Inadequate husbandry (eg, a lack of hoof hygiene and excessive moisture), genetic predisposition, (auto)immune reactions, microorganisms (such as fungi, spirochetes, and other anaerobic bacteria), and bovine papillomaviruses have been suggested to be involved in the development of canker. 3,9,19,20,28 However, for any of these, a causal association with the development of disease remains to be established. Morphological studies of hoof canker tissues are rare.…”

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Equine Hoof Canker: Cell Proliferation and Morphology

et al. 2017

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Hoof canker is described as progressive pododermatitis of the equine hoof with absent epidermal cornification and extensive proliferation of the dermal papillary body; however, in-depth research on the type of proliferative activity has not yet been reported. The aim of the present study was to determine cell-specific proliferation patterns together with morphological analysis of hoof canker tissue.Tissues removed during surgery from 19 horses presented for treatment of canker were compared to similar postmortem tissues of healthy hooves of 10 horses.Morphological alterations visible in light microscopy were assessed semiquantitatively and graded for severity. Proliferative activity was evaluated by means of anti-PCNA (proliferative cell nuclear antigen) and anti-Ki67 immunohistochemistry.Histologically, canker tissue showed five major morphological alterations, the presence of lacunae, vacuoles, giant cells, hemorrhage and inflammation, not seen in control tissue. Also, there was a notable koilocytotic appearance of keratinocytes in canker tissue. Immunohistochemistry revealed increased levels of PCNA protein expression in keratinocytes and fibroblasts of canker tissue compared to control tissue. In control tissue, keratinocytes showed higher levels of Ki67 compared to canker tissue, while the dermal fibroblasts of both groups showed similar levels of Ki67, indicating similar proliferative activity of less than 3% of total dermal fibroblasts.These results demonstrate that, in contrast to previous reports, there is no evidence for increased proliferative activity of the dermal papillary body associated with hoof canker. Increased levels of PCNA protein expression and morphological alterations indicate dysregulation of keratinocyte differentiation constitutes a key event in equine hoof canker development. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 3,9,19,20,28 However, for any of these, a causal association with the development of disease remains to be established. Morphological studies of hoof canker tissues are rare. 24, 26Ballooning of the keratinocytes, mainly in the Stratum germinativum of the frog, has been reported together with the occurrence of perinuclear vacuoles in the cells of deep layers of the Stratum spongiosum; the cells of the corium are covered by a thin layer of defective epidermis, leading to an increased risk of infection and bleeding. 26To our knowledge, the proliferative character of canker has not yet been analyzed in detail. Immunohistochemistry allows characterization of tissue proliferation, as has been shown in a number of potentially metaplastic or neoplastic tissues. 4,1...

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