Recurrent cardiovascular events in patients with newly diagnosed acute coronary syndrome: Influence of diabetes and its management with medication

Komaru, Yohei; Takeuchi, Tadashi; Suzuki, Luka; Asano, Taku; Urayama, Kevin Y.

doi:10.1016/j.jdiacomp.2019.107511

Cited by 13 publications

(24 citation statements)

References 38 publications

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“…The injurious effects of diabetes mellitus include macrovascular and microvascular complications, such as brain, heart, kidney, retina, and other important organ damage (Shi and Vanhoutte, 2017). Diabetes mellitus has become one of the most important risk factors for the occurrence of coronary arterial disease (Komaru et al, 2020), leading to myocardial infarction, heart failure, and even sudden death (Junttila et al, 2018;Lorenzo-Almorós and Cepeda-Rodrigo, 2020). More and more studies in recent years have demonstrated that diabetes mellitus accelerates the progress of coronary heart disease and promotes the clinical manifestations of myocardial ischemia in advance (van den Heuvel et al, 2012).…”

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confidence: 99%

BK Channel Dysfunction in Diabetic Coronary Artery: Role of the E3 Ubiquitin Ligases

Qian

Liu

et al. 2020

Front. Physiol.

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Diabetic coronary arterial disease is a leading cause of morbidity and mortality in diabetic patients. The impaired function of large-conductance calcium-activated potassium channels (BK channels) is involved in diabetic coronary arterial disease. Many studies have indicated that the reduced BK channel expression in diabetic coronary artery is attributed to ubiquitin-mediated protein degradation by the ubiquitin-proteasome system. This review focuses on the influence and the mechanisms of BK channel regulation by E3 ubiquitin ligases in diabetic coronary arterial disease. Thus, BK channels regulated by E3 ubiquitin ligase may play a pivotal role in the coronary pathogenesis of diabetic mellitus and, as such, is a potentially attractive target for therapeutic intervention.

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confidence: 99%

BK Channel Dysfunction in Diabetic Coronary Artery: Role of the E3 Ubiquitin Ligases

Qian

Liu

et al. 2020

Front. Physiol.

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“…* These authors contributed equally to this paper. 1 Department of Cardiology, the first medical center, Chinese PLA General Hospital, Beijing, China. 2 National Clinical Research Center of Geriatrics Disease, Beijing, China.…”

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confidence: 99%

“…ACS is clinical subtype of CHD, which is a group of clinical syndromes caused by acute myocardial ischemia. The clinical classification includes unstable angina pectoris, acute ST-segment elevation myocardial infarction (STEMI), and acute non-ST-segment elevation myocardial infarction (NSTEMI) [1]. Microcirculation disorder, type of atherosclerotic plaque, function of vascular endothelium, decrease of coronary blood flow and inflammatory response are all important mechanisms for the occurrence of ACS [2].…”

Section: Introductionmentioning

confidence: 99%

Evaluation on Prognostic Ability of Serum Uric Acid for Very Old Acute Coronary Syndrome Patients with Diabetes Mellitus: A Prospective Cohort Study

Yang

Wang

et al. 2020

Preprint

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Background This study sought to evaluate the prognostic power of serum uric acid (UA) in predicting adverse events of very old acute coronary syndrome (ACS) patients with diabetes mellitus (DM).Methods This analysis involved 718 ACS patients > 80 years old who were collected general clinical data and baseline blood biochemical indicators prospectively from January 2006 to December 2012, and these patients were classified into two groups based on DM, then followed up after discharge. Kaplan–Meier method was performed for major adverse cardiac events (MACE) rates and all-cause mortality. Multivariate Cox regression was performed to analyze the relationship between UA level and long-term clinical prognosis. Receiver operating characteristic (ROC) curve was analyzed to predict the cutoff value of UA of the very old ACS patients with DM.Results There were 242 and 476 patients in groups DM and non-DM(NDM) and the follow-up time after discharge was 40–120 months (median: 63 months; interquartile range: 51–74 months). The differences in all-cause mortality, cardiac mortality and MACE rates in DM and NDM patients between the control group were statistically significant (P = 0.001). All-cause mortality, cardiac mortality and MACE incidence in DM patients with moderate and high UA level were significantly higher than those in control group (P = 0.001). There were statistically significant differences in long-term survival rates among the ACS groups (P = 0.001), and long-term survival rates decreased significantly with the increase of UA level. UA (OR = 2.106, 95%CI = 1.244–3.568, P = 0.006) was found to be an independent risk factor for all-cause mortality and MACE in very old ACS patients with DM. The cutoff value of UA was 353.6 µmol/L (sensitivity: 67.4%; specificity: 65.7%). The elevation of serum UA level play an important role in predicting the development of all-cause mortality in elderly ACS patients with DM.Conclusion Serum UA level is a strong independent predictor of long-term all-cause death and MACE in very old ACS patients with DM.

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Section: Fundingmentioning

confidence: 99%

“…ACS is clinical subtype of CHD, which is a group of clinical syndromes caused by acute myocardial ischemia. The clinical classification includes unstable angina pectoris, acute ST-segment elevation myocardial infarction (STEMI), and acute non-ST-segment elevation myocardial infarction (NSTEMI) [1] . Microcirculation disorder, type of atherosclerotic plaque, function of vascular endothelium, decrease of coronary blood flow and inflammatory response are all important mechanisms for the occurrence of ACS [2] .…”

Section: Introductionmentioning

confidence: 99%

Evaluation on prognostic ability of serum uric acid for very old acute coronary syndrome patients with diabetes mellitus

Jiao¹,

Wang²,

Xi³

et al. 2020

Preprint

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Background and aims This study sought to evaluate the prognostic power of serum uric acid (UA) in predicting adverse events of very old acute coronary syndrome (ACS) patients with diabetes mellitus (DM). Patients and methods This analysis involved 718 ACS patients >80 years old who were collected general clinical data and baseline blood biochemical indicators prospectively from January 2006 to December 2012, and these patients were classified into two groups based on DM, then followed up after discharge. Kaplan–Meier method was performed for major adverse cardiac events (MACE) rates and all-cause mortality. Multivariate Cox regression was performed to analyze the relationship between UA level and long-term clinical prognosis. Receiver operating characteristic (ROC) curve was analyzed to predict the cutoff value of UA of the very old ACS patients with DM. Results There were 242 and 476 patients in groups DM and non-DM(NDM) and the follow-up time after discharge was 40-120 months (median: 63 months; interquartile range: 51–74 months). The differences in all-cause mortality, cardiac mortality and MACE rates in DM and NDM patients between the control group were statistically significant (P=0.001). All-cause mortality, cardiac mortality and MACE incidence in DM patients with moderate and high UA level were significantly higher than those in control group (P=0.001). There were statistically significant differences in long-term survival rates among the ACS groups (P=0.001), and long-term survival rates decreased significantly with the increase of UA level. UA (OR=2.106, 95%CI=1.244-3.568, P=0.006) was found to be an independent risk factor for all-cause mortality and MACE in very old ACS patients with DM. The cutoff value of UA was 353.6μmol/L (sensitivity: 67.4%; specificity: 65.7%). The elevation of serum UA level play an important role in predicting the development of all-cause mortality in elderly ACS patients with DM. Conclusion Serum UA level is a strong independent predictor of long-term all-cause death and MACE in very old ACS patients with DM.

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Recurrent cardiovascular events in patients with newly diagnosed acute coronary syndrome: Influence of diabetes and its management with medication

Cited by 13 publications

References 38 publications

BK Channel Dysfunction in Diabetic Coronary Artery: Role of the E3 Ubiquitin Ligases

BK Channel Dysfunction in Diabetic Coronary Artery: Role of the E3 Ubiquitin Ligases

Evaluation on Prognostic Ability of Serum Uric Acid for Very Old Acute Coronary Syndrome Patients with Diabetes Mellitus: A Prospective Cohort Study

Evaluation on prognostic ability of serum uric acid for very old acute coronary syndrome patients with diabetes mellitus

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