Recurrent cerebral hemorrhage with brain metastasis of choriocarcinoma presenting as initially absent and later identified as oncotic aneurysms: A case report and literature review

Kim, Sang-Uk; Huh, Jae Won; Kim, Dal-Soo; Huh, Choon-Woong

doi:10.1016/j.inat.2020.101043

Cited by 2 publications

(2 citation statements)

References 32 publications

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“…The pathogenesis of an oncotic aneurysm is due to neoplastic vascular embolization with obstruction of distal cerebral vessels or with infiltration of the vasa vasorum followed by focal destruction of the intima, internal elastic lamina, and medial layers, leading to the development of an aneurysm. Brain angiography can be useful to study the characteristics of oncotic aneurysms, but identification of these lesions can be challenging in the case of cerebral hemorrhage ( 38 , 39 ).…”

Section: Clinical Presentation Diagnosis Staging and Risk Stratificationmentioning

confidence: 99%

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From Uterus to Brain: An Update on Epidemiology, Clinical Features, and Treatment of Brain Metastases From Gestational Trophoblastic Neoplasia

et al. 2022

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In this review, we provide the state of the art about brain metastases (BMs) from gestational trophoblastic neoplasia (GTN), a rare condition. Data concerning the epidemiology, clinical presentation, innovations in therapeutic modalities, and outcomes of GTN BMs are comprehensively presented with particular attention to the role of radiotherapy, neurosurgery, and the most recent chemotherapy regimens. Good response rates have been achieved thanks to multi-agent chemotherapy, but brain involvement by GTNs entails significant risks for patients’ health since sudden and extensive intracranial hemorrhages are possible. Moreover, despite the evolution of treatment protocols, a small proportion of these patients ultimately develops a resistant disease. To tackle this unmet clinical need, immunotherapy has been recently proposed. The role of this novel option for this subset of patients as well as the achieved results so far are also discussed.

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Section: Clinical Presentation Diagnosis Staging and Risk Stratificationmentioning

confidence: 99%

“…The role of intracranial surgery is actually limited to salvage treatment in case of intracranial hypertension, hemorrhage, edema, or for resection of chemoresistant metastasis ( 23 , 28 , 38 ).…”

Section: Treatment Optionsmentioning

confidence: 99%