Recurrent chondrosarcoma of the larynx

Zhou, Huixin; Wang, Jing; Liu, Yang; Zhang, Hui-Mao

doi:10.1097/md.0000000000004118

Cited by 8 publications

(7 citation statements)

References 18 publications

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“…The five-year survival rate and tendency of metastasis depends on the differantion grade of the tumor. Low grade chondrosarcoma has a 90% five-year survival rate and shows no tendency of metastasis (16). In our case, the patient is still alive four years after his surgical intervention.…”

Section: Discussionmentioning

confidence: 48%

Immunohistochemical Analysis of Laryngeal Chondrosarcoma: A Case Report

Mitroi¹,

Căpitănescu²,

Foarfă³

et al. 2017

West Indian Med J

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Laryngeal chondrosarcoma is a rare entity, reportedly comprising less than 1% of all laryngeal tumors. Obtaining the necessary tissue for a histological examination can be difficult. Another difficult step is distinguishing a chondrosarcoma from a chondroma. This differentiation can be achieved through immunohistochemical analysis. We present the histopathological and immunohistochemical aspects of a laryngeal chondrosarcoma, well differentiated and with low grade malignancy, located on the cricoid cartilage. Anatomopathological examination confirms the diagnosis of low-grade malignancy chondrosarcoma and CT scans show no metastasis, therefore the tumor is removed through total laryngectomy with primary pharyngeal reconstruction with a favourable evolution. The histopathological examination used the classical Hematoxylin-Eosin technique and the immunohistochemical method was based on soluble immunoenzymatic complexes. This is the first article in the literature that analyzes the immunohistochemical aspects of the laryngeal chondrosarcoma. We consider this study very important beacause of the high difficulty level of obtaining the necessary bioptic material and differentiating it from a laryngeal chondroma. The four antibodies we studied allow us to give the certain diagnosis of a laryngeal chondrosarcoma.

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Section: Discussionmentioning

confidence: 48%

Immunohistochemical Analysis of Laryngeal Chondrosarcoma: A Case Report

Mitroi¹,

Căpitănescu²,

Foarfă³

et al. 2017

West Indian Med J

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“…The clinical manifestations of laryngeal ChS may be nonspecific[ 2 ]. Symptoms of laryngeal ChS include dyspnoea (if intraluminal tumour growth is dominant), dysphagia (if pharynx infiltration is dominant), and progressive hoarseness.…”

Section: Discussionmentioning

confidence: 99%

“…Since 75% of laryngeal ChS forms in the cricoid cartilage, which is considered crucial for laryngeal function, its preservation is often not possible. Total laryngectomy is recommended in cases where more than half of the cricoid cartilage is destroyed by tumour tissue, as well as in cases involving relapse[ 2 , 7 ]. Nonsurgical treatment modalities are rarely used for the treatment of this tumour[ 8 ].…”

Section: Discussionmentioning

confidence: 99%

“…These tumours represent 0.1% of all tumours of the head and neck region and may occur in the nasal cavity, maxilla, and mandible in addition to the larynx. In regard to the larynx, ChS accounts for 1% of all laryngeal neoplasms[ 2 , 3 ]. Although these tumours rarely occur in the larynx, they have the second highest frequency after tumours originating from epithelial tissue, squamous cell carcinoma and adenocarcinoma[ 4 ].…”

Section: Introductionmentioning

confidence: 99%

“…Most often, the clinical symptoms are dominated by dyspnoea, dysphasia, dysphonia, and cough with hoarseness. The aetiology of tumour formation remains unclear[ 1 , 2 ]. In addition to clinical examinations, computed tomography and magnetic resonance imaging are recommended as diagnostic imaging methods.…”

Section: Introductionmentioning

confidence: 99%

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Low-grade chondrosarcoma of the larynx: A case report

Vučković¹,

Klisić²,

Filipović³

et al. 2021

WJCC

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BACKGROUND Chondrosarcomas of the larynx are malignant tumours that most commonly originate from the hyaline cartilage. Chondrosarcoma of the larynx, the most common type of low-grade tumour, accounts for 1% of all laryngeal neoplasms. CASE SUMMARY We present the case of a 60-year-old female patient who developed progressive hoarseness and shortness of breath over a 2-mo period. The patient had undergone resection of a laryngeal tumour 14 years before the aforementioned symptoms occurred, and histopathological analysis indicated that it was a chondroma. During the assessment of the patient, a submucosal, oval-shaped tumour was detected that was predominantly located on the left side of the larynx and was approximately 6 cm in size. The decision to perform left partial vertical laryngectomy was made. A pathohistological diagnosis of low-grade chondrosarcoma was made. Considering the results of pathohistological analysis and the positive margins of the resection, a total laryngectomy was performed. During the 12-mo follow-up, no local relapse or regional or distant metastases was detected. CONCLUSION Chondrosarcoma of the larynx must be considered in the differential diagnosis of laryngeal submucosal tumours. It is crucial to carefully sample of tumour tissue, differentiate chondroma and chondrosarcoma, and consider the possibility of malignant changes from chondroma to chondrosarcoma.

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