Recurrent conjunctival papilloma progressing into squamous cell carcinoma with change of HPV-finding during the course

Bredow, Laura; Martin, Gottfried; Reinhard, Thomas; Mittelviefhaus, Hans; Auw-Haedrich, Claudia

doi:10.1136/bjo.2007.132852

Cited by 10 publications

(8 citation statements)

References 11 publications

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“…Rarely, they can undergo malignant transformation, especially for those with inverted growth pattern or recurrence. [ 17 18 ] Long-term surveillance is required for these patients.…”

Section: Discussionmentioning

confidence: 99%

Conjunctival papilloma: Clinical features, outcome, and factors related to recurrence

Huang

Yang

et al. 2018

Taiwan J Ophthalmol

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PURPOSE:The purpose of the study was to evaluate the clinical features, treatment, and outcome of patients with conjunctival papilloma.MATERIALS AND METHODS:Twenty-two patients (22 eyes) with biopsy-proven conjunctival papilloma between January 2005 and January 2015 in a tertiary medical center were retrospectively reviewed. Clinical profiles, treatment, outcome, and factors related to recurrence were evaluated.RESULTS:There were 16 males (73%) and 6 females (27%), with a mean age of 47 years. The most common location of conjunctival papilloma was the caruncle (43%), followed by palpebral conjunctiva (29%), bulbar conjunctiva (14%), and fornix (14%). Recurrence developed in five patients (22.7%). The risk of postoperative recurrence was significantly related to the presence of bulbar conjunctival papilloma with corneal involvement (P = 0.043) and surgical excision alone (P = 0.039). One case with multiple recurrences developed nonkeratinizing carcinoma. Two young females developed conjunctival papilloma even after receiving human papillomavirus vaccinations.CONCLUSION:The recurrence of conjunctival papilloma is not uncommon, especially for those patients underwent surgical excision alone. Surgical excision with adjunctive therapy and long-term follow-up is rational for the treatment of conjunctival papilloma.

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“…Rarely, they can undergo malignant transformation, especially for those with inverted growth pattern or recurrence. [ 17 18 ] Long-term surveillance is required for these patients.…”

Section: Discussionmentioning

confidence: 99%

Conjunctival papilloma: Clinical features, outcome, and factors related to recurrence

Huang

Yang

et al. 2018

Taiwan J Ophthalmol

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“…Bei jüngeren Patienten liegt häufig eine prädisponierende systemische Erkrankung wie eine atopische Dermatitis oder HIV-Infektion vor 31 , 32 , 33 , 34 . Wenige Fälle stehen im Zusammenhang mit einer HPV-Infektion 19 .…”

Section: Epitheliale Tumorenunclassified

“…B. 16 oder 18 in dem Papillom vorliegen [19]. Eine HPV-Impfung scheint nicht vollständig vor einem Bindehautpapillom zu schützen, wenn andere Low-Risk-Typen als die, gegen welche der Impfstoff Gardasil gerichtet ist, (HPV-6, HPV-11), pathogenetisch beteiligt sind [20].…”

Section: Epidemiologie Und äTiologieunclassified

“…Interessanterweise wurde nachgewiesen, dass die Anwesenheit von HPV und die Überexpression von p16INK4 mit besseren klinischen Ergebnissen korrelieren [30] Bindehautkarzinom Ätiologie Bei jüngeren Patienten liegt häufig eine prädisponierende systemische Erkrankung wie eine atopische Dermatitis oder HIV-Infektion vor [31 -34]. Wenige Fälle stehen im Zusammenhang mit einer HPV-Infektion [19].…”

Section: Prognoseunclassified

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Bindehautdegenerationen und -neoplasien

Auw-Hädrich¹,

Gasser²,

Reinhard³

2022

Klin Monbl Augenheilkd

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ZusammenfassungErhabenheiten der Bindehaut entstehen durch Gewebevermehrung, die entweder degenerativ oder neoplastisch, aber auch entzündlich sein können. In diesem Artikel werden degenerative (Pterygium und Pinguecula) sowie benigne und maligne neoplastische Bindehautveränderungen (epitheliale, melanozytäre und vaskuläre Tumoren, Choristome sowie Metastasen) bezüglich der Pathogenese, Symptome, Diagnostik und aktuellem Stand der Behandlung dargestellt.

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“…The etiology of conjunctival SCC and Pap is not clarified for the most part. Whereas the formation of Pap is strongly associated with the human papilloma virus (HPV) types 6 and 11, which induce proliferation of dermal connective tissue followed by acanthosis and hyperkeratosis 11 , infections with HPV type 16 and 18 or human immunodeficiency virus (HIV) are discussed as possible risk factors for SCC 12,13 . For SCC, UV radiation has further been postulated to induce DNA damage and mutations in the tumor suppressor gene p53 14,15 and reactivate latent HPV and HIV infections 16,17 , thus increasing the risk for conjunctival SCC.…”

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confidence: 99%

MACE RNA sequencing analysis of conjunctival squamous cell carcinoma and papilloma using formalin-fixed paraffin-embedded tumor tissue

Boneva

Schlecht

Zhang

et al. 2020

Sci Rep

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Recent advances in the field of biomedical research allow for elucidation of the transcriptional signature of rare tumors such as conjunctival squamous cell carcinoma (SCC). In this study we compare its expression profile to conjunctival papilloma (Pap) and healthy conjunctival tissue (Ctrl) and develop a classification tool to differentiate these entities. Seven conjunctival SCC, seven Pap and ten Ctrl were formalin-fixed and paraffin-embedded (FFPE) and analyzed using Massive Analysis of cDNA Ends (MACE) RNA sequencing. Differentially expressed genes (DEG) and gene ontology (GO) clusters were explored and the abundance of involved cell types was quantified by xCell. Finally, a classification model was developed to distinguish SCC from Pap and Ctrl. Among the most prominent DEG in SCC a plethora of keratins were upregulated when compared to Pap and Ctrl. xCell analysis revealed an enrichment of immune cells, including activated dendritic cells and T-helper type 1 cells (Th1), in SCC when compared to Ctrl. The generated classification model could reliably discriminate between the three entities according to the expression pattern of 30 factors. This study provides a transcriptome-wide gene expression profile of rare conjunctival SCC. The analysis identifies distinct keratins, as well as dendritic and Th1 cells as important mediators in SCC. Finally, the provided gene expression classifier may become an aid to the conventional histological classification of conjunctival tumors in uncertain cases.

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Recurrent conjunctival papilloma progressing into squamous cell carcinoma with change of HPV-finding during the course

Cited by 10 publications

References 11 publications

Conjunctival papilloma: Clinical features, outcome, and factors related to recurrence

Conjunctival papilloma: Clinical features, outcome, and factors related to recurrence

Bindehautdegenerationen und -neoplasien

MACE RNA sequencing analysis of conjunctival squamous cell carcinoma and papilloma using formalin-fixed paraffin-embedded tumor tissue

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