Recurrent Connection Patterns of Corticostriatal Pyramidal Cells in Frontal Cortex

Morishima, Mieko; Kawaguchi, Yasuo

doi:10.1523/jneurosci.0252-06.2006

Cited by 263 publications

(350 citation statements)

References 73 publications

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“…Layer 5 pyramidal neurons are themselves a heterogenous group in terms of their axonal projections and synaptic connectivity (Morishima and Kawaguchi 2006;Wang et al 2006), and therefore it is possible that ACh differentially gates the excitability of these neurons. However, our finding of only a single layer 5 pyramidal neuron (from the visual cortex) not inhibited by ACh suggests cholinergic inhibition is a general feature of the vast majority of layer 5 pyramidal cells, and not restricted to specific subsets of neurons.…”

Section: Cholinergic Inhibition Of Pyramidal Neuronsmentioning

confidence: 99%

Heterogeneity of Phasic Cholinergic Signaling in Neocortical Neurons

Gulledge¹,

Park²,

Kawaguchi³

et al. 2007

Journal of Neurophysiology

184

195

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ACh) is a neurotransmitter critical for normal cognition. Here we demonstrate heterogeneity of cholinergic signaling in neocortical neurons in the rat prefrontal, somatosensory, and visual cortex. Focal ACh application (100 M) inhibited layer 5 pyramidal neurons in all cortical areas via activation of an apamin-sensitive SK-type calcium-activated potassium conductance. Cholinergic inhibition was most robust in prefrontal layer 5 neurons, where it relies on the same signal transduction mechanism (M1-like receptors, IP 3 -dependent calcium release, and SK-channels) as exists in somatosensory pyramidal neurons. Pyramidal neurons in layer 2/3 were less responsive to ACh, but substantial apamin-sensitive inhibitory responses occurred in deep layer 3 neurons of the visual cortex. ACh was only inhibitory when presented near the somata of layer 5 pyramidal neurons, where repetitive ACh applications generated discrete inhibitory events at frequencies of up to ϳ0.5 Hz. Fast-spiking (FS) nonpyramidal neurons in all cortical areas were unresponsive to ACh. When applied to non-FS interneurons in layers 2/3 and 5, ACh generated mecamylamine-sensitive nicotinic responses (38% of cells), apamin-insensitive hyperpolarizing responses, with or without initial nicotinic depolarization (7% of neurons), or no response at all (55% of cells). Responses in interneurons were similar across cortical layers and regions but were correlated with cellular physiology and the expression of biochemical markers associated with different classes of nonpyramidal neurons. Finally, ACh generated nicotinic responses in all layer 1 neurons tested. These data demonstrate that phasic cholinergic input can directly inhibit projection neurons throughout the cortex while sculpting intracortical processing, especially in superficial layers.

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Section: Cholinergic Inhibition Of Pyramidal Neuronsmentioning

confidence: 99%

Heterogeneity of Phasic Cholinergic Signaling in Neocortical Neurons

Gulledge¹,

Park²,

Kawaguchi³

et al. 2007

Journal of Neurophysiology

184

195

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show abstract

“…Among the subcortical targets, neurons in the pontine nuclei that relay information to the cerebellum are involved in supervised learning of procedural memory (Ito, 2011), whereas neurons in the striatum of the basal ganglia are involved in reinforcement learning (Schultz et al, 1997;Glimcher, 2011). Recently, two subtypes of layer 5 pyramidal cells projecting to the striatum and pons have been revealed to show unique connectivity (Morishima and Kawaguchi, 2006;Otsuka and Kawaguchi, 2008;Brown and Hestrin, 2009;Morishima et al, 2011). Crossed corticostriatal (CCS) cells innervate both the ipsilateral and contralateral striatum, but do not send axons to the pons, whereas corticopontine (CPn) cells project to the ipsilateral striatum and pons, but not to the contralateral striatum (Cowan and Wilson, 1994;Reiner et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Specialized Cortical Subnetworks Differentially Connect Frontal Cortex to Parahippocampal Areas

Hirai

Morishima²,

Karube³

et al. 2012

J. Neurosci.

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How information is manipulated and segregated within local circuits in the frontal cortex remains mysterious, in part because of inadequate knowledge regarding the connectivity of diverse pyramidal cell subtypes. The frontal cortex participates in the formation and retrieval of declarative memories through projections to the perirhinal cortex, and in procedural learning through projections to the striatum/pontine nuclei. In rat frontal cortex, we identified two pyramidal cell subtypes selectively projecting to distinct subregions of perirhinal cortex (PRC) .

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“…McGuire et al (1991) described, in the rhesus monkey, a crossed projection to n caudatus and putamen from prefrontal cortex and the supplementary motor area (SMA). The existence of crossed cortico-striatal projections is well documented in the rodents (Carman et al 1965;Wilson 1987;Morishima and Kawaguchi 2006;Alloway et al 2009;Shepherd 2013) but somewhat neglected in primates (Lieu and Subramanian 2012). Given the current enhanced interest in the striatal and corticostriatal functions (Kress et al 2013;Smith and Graybiel 2013;Stephenson-Jones et al 2013;Znamenskiy and Zador 2013;Reig and Silberberg 2014) also related to their role in psychosis (Koch et al 2014;Burguière et al 2014;Nakamae et al 2014), we reinvestigated the crossed cortico-striatal connections using modern histological tract tracing in the monkey as well as diffusion tractography (DT) in monkeys and human.…”

mentioning

confidence: 99%

The Crossed Projection to the Striatum in Two Species of Monkey and in Humans: Behavioral and Evolutionary Significance

et al. 2016

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The corpus callosum establishes the anatomical continuity between the 2 hemispheres and coordinates their activity. Using histological tracing, single axon reconstructions, and diffusion tractography, we describe a callosal projection to n caudatus and putamen in monkeys and humans. In both species, the origin of this projection is more restricted than that of the ipsilateral projection. In monkeys, it consists of thin axons (0.4-0.6 μm), appropriate for spatial and temporal dispersion of subliminal inputs. For prefrontal cortex, contralateral minus ipsilateral delays to striatum calculated from axon diameters and conduction distance are <2 ms in the monkey and, by extrapolation, <4 ms in humans. This delay corresponds to the performance in Poffenberger's paradigm, a classical attempt to estimate central conduction delays, with a neuropsychological task. In both species, callosal cortico-striatal projections originate from prefrontal, premotor, and motor areas. In humans, we discovered a new projection originating from superior parietal lobule, supramarginal, and superior temporal gyrus, regions engaged in language processing. This projection crosses in the isthmus the lesion of which was reported to dissociate syntax and prosody. The projection might originate from an overproduction of callosal projections in development, differentially pruned depending on species.

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Recurrent Connection Patterns of Corticostriatal Pyramidal Cells in Frontal Cortex

Cited by 263 publications

References 73 publications

Heterogeneity of Phasic Cholinergic Signaling in Neocortical Neurons

Heterogeneity of Phasic Cholinergic Signaling in Neocortical Neurons

Specialized Cortical Subnetworks Differentially Connect Frontal Cortex to Parahippocampal Areas

The Crossed Projection to the Striatum in Two Species of Monkey and in Humans: Behavioral and Evolutionary Significance

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