Recurrent cutaneous squamous cell carcinoma in the occipital scalp with clinical perineural invasion developing jugular foramen syndrome

Senda, Akiyoshi; Kaku, Yo; Komori, Takaya; Ueda, Marina; Yonekura, Satoru; Yoshikawa, Yoshiaki; Kabashima, Kenji

doi:10.1016/j.jdcr.2023.05.038

JAAD Case Reports

2023

DOI: 10.1016/j.jdcr.2023.05.038

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Recurrent cutaneous squamous cell carcinoma in the occipital scalp with clinical perineural invasion developing jugular foramen syndrome

Akiyoshi Senda

Yo Kaku

Takaya Komori

et al.

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2024

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Perineural Invasion in Head and Neck Cutaneous Squamous Cell Carcinoma

Pei,

Wiefels,

Harris

et al. 2024

Cancers

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Background/Objectives: Cutaneous squamous cell carcinoma (cSCC) is the second most common skin cancer, with a lifetime risk of 14–20% that is rising every year. Although prognosis for cSCC is generally good, certain high-risk features of cSCC portend increased rates of nodal and distant metastasis, recurrence, and disease-specific mortality. One such high-risk factor is perineural invasion (PNI), which is broadly defined as the invasion of cancer into and around nerves. Compared to other high-risk factors, PNI presence is associated with the highest risk for locoregional and distant metastasis. Still, the mechanisms underlying the pathogenesis of PNI remain poorly understood. Recent studies suggest the migration and invasion of tumors into nerves is a result of complex molecular crosstalk within the tumor-nerve microenvironment, wherein the milieu of signaling molecules simultaneously promote neuronal growth and tumor cell invasion. Methods: Understanding the molecular and cellular mechanisms that promote PNI will lead to future developments of targeted therapies that may improve locoregional control and survival. Results/Conclusions: In our article, we aim to provide a comprehensive review of recent findings about the pathogenesis of PNI, clinical implications of PNI-positive disease in cSCC, available treatment modalities, and potential future therapeutic targets.

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Perineural Invasion in Head and Neck Cutaneous Squamous Cell Carcinoma

Pei,

Wiefels,

Harris

et al. 2024

Cancers

View full text Add to dashboard Cite

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Recurrent cutaneous squamous cell carcinoma in the occipital scalp with clinical perineural invasion developing jugular foramen syndrome

Cited by 1 publication

References 8 publications

Perineural Invasion in Head and Neck Cutaneous Squamous Cell Carcinoma

Perineural Invasion in Head and Neck Cutaneous Squamous Cell Carcinoma

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