Recurrent encephaloclastic cyst induced by intraventricular topotecan

Mella, Divya; Kamiya-Matsuoka, Carlos; Liao, Bing; Tummala, Sudhakar; Groot, John F. de

doi:10.1016/j.jns.2014.12.024

Cited by 6 publications

(4 citation statements)

References 6 publications

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“…Intraventricular topotecan was discontinued and both patients demonstrated sustained clinical and radiological response. Albeit complications of intraventricular delivery of drugs to HGG patients by Ommaya reservoirs may thus be managed (35), the data confirm that addition of intraventricular chemotherapy does not lead to survival benefit or improved response to neurooncologic patients, partially linked to inability to achieve clinically relevant tissue penetration (9).…”

Section: Ommaya Reservoirsmentioning

confidence: 83%

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Advances in drug delivery to high grade gliomas

Fròsina

2016

Brain Pathology

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If cancer is hard to be treated, brain cancer is even more, caused by the inability of many effective drugs given systemically to cross the blood brain and blood tumor barriers and reach adequate concentrations at the tumor sites. Effective delivery of drugs to brain cancer tissues is thus a necessary, albeit not sufficient, condition to effectively target the disease. In order to analyze the current status of research on drug delivery to high grade gliomas (HGG-WHO grades III and IV), the most frequent and aggressive brain cancers, a literature search was conducted in PubMed using the terms: "drug delivery and brain tumor" over the publication year 2015. Currently explored drug delivery techniques for HGG include the convection and permeabilization-enhanced deliveries, drug-releasing depots and Ommaya reservoirs. The efficacy/safety ratio widely varies among these techniques and the success of current efforts to increase this ratio widely varies as well.

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Section: Ommaya Reservoirsmentioning

confidence: 83%

“…Ommaya reservoirs provide fast access and reliable drug delivery to cerebral spinal fluid. Complications of Ommaya reservoir placement and its use mainly consist of early infectious causes (35). Two rare cases of encephaloclastic cyst with intraventricular topotecan use have been reported.…”

Section: Ommaya Reservoirsmentioning

confidence: 99%

Advances in drug delivery to high grade gliomas

Fròsina

2016

Brain Pathology

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“…MTX CNS toxicity results from the disruption of the blood–brain barrier leading to focal necrotising changes and subsequent development of local chemical encephalitis . Removal of the OR is recommended, thereby eliminating CSF’s path of least resistance along the catheter .…”

mentioning

confidence: 87%

“…Known neurotoxicities include aseptic meningitis, seizures and polyradiculopathy . Encephaloclastic cysts are non‐infectious complications rarely seen in the OR resulting from the cystic dilatation of the brain parenchyma around a catheter in response to a chemotherapeutic agent . These cysts have been seldom reported and are believed to result from extravasation or back‐flow of CSF along the catheter …”

mentioning

confidence: 99%