Recurrent Endometrial Adenocarcinoma Presenting as a Solitary Humeral Metastasis

Schöls, W.A.; Kock, H.C.L.V.; Etten, F.H.P.M. van

doi:10.1006/gyno.1995.1282

Cited by 23 publications

(17 citation statements)

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“…When literature was reviewed, we found 19 such cases previously reported [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19]. In addition, bone metastases of endometrial adenocarcinoma is rarely presenting feature.…”

Section: Introductionmentioning

confidence: 89%

Solitary bone metastasis in the tibia as a presenting sign of endometrial adenocarcinoma: a case report and the review of the literature

Kaya

Ölmezoğlu

Eren

et al. 2007

Clin Exp Metastasis

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Section: Introductionmentioning

confidence: 89%

Solitary bone metastasis in the tibia as a presenting sign of endometrial adenocarcinoma: a case report and the review of the literature

Kaya

Ölmezoğlu

Eren

et al. 2007

Clin Exp Metastasis

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“…10 Several case reports reported unusual bony sites for metastases from EC, such as the calcaneous, talus, metatars, humerus, mandible, skull (Table 1). [2][3][4][5][6][7][11][12][13][14][15][16] In evaluation of stage I cases, the range of time to bone metastasis varied from 4 months to 3 years. 2,4,12,13,16 The survival was longer in cases with isolated bone metastasis, compared those with distant metastasis.…”

Section: Discussionmentioning

confidence: 99%

“…[2][3][4][5][6][7][11][12][13][14][15][16] In evaluation of stage I cases, the range of time to bone metastasis varied from 4 months to 3 years. 2,4,12,13,16 The survival was longer in cases with isolated bone metastasis, compared those with distant metastasis. However, Cooper et al 3 reported a case with metastatic endometrial carcinoma who survived more than five years with bone metastases on multimodality treatment: systemic chemotherapy and hormonal therapy for primary disease and local radiotherapy for metastasis, and stated that the presence of bone metastases found on the distal extremities is often associated with poor prognosis.…”

Section: Discussionmentioning

confidence: 99%

Isolated Bone Metastases in Early Stage Endometrial Adenocarcinoma: A Case Report and Review of the Literature

Kurt¹

2011

UHOD

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Isolated skeletal metastasis of endometrial carcinoma is very unusual. Herein, we report a 62-year-old woman diagnosed as FIGO stage IC, grade I, endometrial carcinoma who was found to have isolated femur and tibia metastases just after completing local radiotherapy. Incisional biopsy revealed metastatic adenocarcinoma. Following radiotherapy, medroxyprogesterone acetate and zoledronic acid was given. After a month, spontaneous right proximal femur fracture occurred and new bone metastasis was detected. Local radiotherapy and six cycles of paclitaxel and carboplatin were given; however, during a 3-year follow-up, bone metastases progressed. We review the endometrial carcinoma with bone metastasis in literature. Keywords: Endometrial carcinoma, Bone metastasis, Treatment ÖZET Erken Evre Endometrium Adenokanserinde ‹zole Kemik Metastazlar›: Olgu Sunumu ve Literatürün Gözden GeçirilmesiEndometrium kanserinin izole kemik metastaz› çok nadirdir. Burada FIGO evre IC, grad I endometrium kanseri tan›s› konulan, lokal radyoterapisi tamamland›ktan hemen sonra izole femur ve tibia metastazlar› saptanan 62 yafl›nda bayan hasta rapor edilmektedir. ‹nsizyonel biyopsi metastatik adenokarsinomu gösterdi. Radyoterapi sonras›nda medroksiprogesteron asetat ve zoledronik asit verildi. Bir ay sonra, spontan sa¤ proksimal femur k›r›¤› meydana geldi ve yeni kemik metastaz› saptand›. Lokal radyoterapi ile 6 kür paklitaksel ve karboplatin kemoterapisi verildi, ancak kemik metastazlar› progresyon gösterdi. Bu makalede endometrium kanserli hastalarda geliflen kemik metastazlar› literatür eflli¤inde tart›fl›lm›flt›r.

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“…A NNEKATHRYN G OODMAN : She had had a gynecologic cancer, and although metastasis to soft tissue is very rare, some cases have been reported. [21][22][23][24] I considered the possibility of diabetic infarction of muscle but performed a biopsy in consultation with the orthopedic oncology service to rule out a tumor. D R .…”

Section: Differential Diagnosismentioning

confidence: 99%

Case 29-1997

Singer¹,

Rosenberg²

1997

N Engl J Med

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A 54-year-old woman was admitted to the hospital because of pain and swelling of the right leg.The patient was otherwise in good health except for non-insulin-dependent diabetes mellitus of five years' duration, which was regulated by diet alone. Five years before admission, an endometrioid carcinoma, stage IC, of the right fallopian tube was treated by abdominal hysterectomy with bilateral salpingo-oophorectomy, followed by the administration of cisplatin and cyclophosphamide. Four months before admission, gynecologic and vaginal cytologic examinations and the CA-125 level were normal.One week before admission, the patient awoke with pain in the right calf and tingling in the right foot. On the following day, a Doppler study of the leg at another hospital was normal. The pain worsened and spread to the right thigh and buttock, limiting extension of the knee.Two days before admission, a Doppler study at this hospital was normal. The prothrombin and partial-thromboplastin times were normal, as were the levels of phosphorus, uric acid, bilirubin, magnesium, electrolytes, and amylase. The results of other laboratory tests are shown in Tables 1 and 2. A computed tomographic (CT) scan of the abdomen and pelvis, obtained after the oral and intravenous administration of contrast material, revealed dependent edema in the subcutaneous fat overlying the paraspinal muscles, without evidence of a pelvic mass, retroperitoneal lymphadenopathy, or ascites. Two days later, the patient was admitted to the hospital.The temperature was 37°C, the pulse was 67, and the respirations were 16. The blood pressure was 215/95 mm Hg.On examination the patient was in pain. The right thigh had a maximal circumference of 53 cm, the left thigh 47 cm, and both calves 40 cm. There was tenderness over the distal portion of the posterior right thigh but not in the anterior thigh or calf. The range of motion was full at the right hip and ankle and was 20° to 110° at the right knee. Motor power and sensation were intact in the right leg. The patient was unable to perform straight-leg raising; Homans's sign was absent.

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Recurrent Endometrial Adenocarcinoma Presenting as a Solitary Humeral Metastasis

Cited by 23 publications

References 0 publications

Solitary bone metastasis in the tibia as a presenting sign of endometrial adenocarcinoma: a case report and the review of the literature

Solitary bone metastasis in the tibia as a presenting sign of endometrial adenocarcinoma: a case report and the review of the literature

Isolated Bone Metastases in Early Stage Endometrial Adenocarcinoma: A Case Report and Review of the Literature

Case 29-1997

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