Recurrent Experimental Allergic Polyganglioradiculoneuritis

Chronic relapsing (Dysimmune) polyneuropathy: Pathogenesis and treatment

“…EAN, a useful model for ADP, can also take a relapsing-remitting course and can serve as a model for CRDP. Waksman [50] observed in one experiment that more than half of the animals with EAN inoculated with heterologous sciatic nerve and adjuvant showed spontaneously recurring episodes of disease activity; in the study of Wisniewski et a1 [53], 2 of 5 monkeys with EAN had a biphasic illness; and of the 52 animals inoculated with heterologous nerves by Pollard et a1 [36], 3 developed a relapsing-remitting course. A more reproducible model of chronic or relapsing-remitting EAN can be produced by rechallenging the animals with the initial peripheral nerve antigen [36, 471, sug-gesting that a mechanism of chronicity may be through reexposure of the previously sensitized host to the same agent that initially triggered the disease.…”

Myelin

“…In early studies, the agent used to produce the disease was whole PNS tissue homogenates. Recently, PNS myelin Wisniewski et al, 1974), the P 2 protein from PNS myelin (Kadlubowski and Hughes, 1979), or peptide fragments of the Pz protein Weise et al, 1980a) have been used as the eliciting antigen. These latter studies (described in Section II.B.6) have been carried out primarily in the rat, with some studies in rabbit, guinea pig, and monkey as weil.…”

“…The time-course of the appearance of clinical signs after injection indicates thatthe initial signs develop within 2-3 weeks, although symptoms have been noted to first appear up to 4 or 5 weeks after the first injectons (Waksman, 1963;Wisniewski et al, 1974). In general, the sooner after challenge the clinical signs appear, the more severe will be the disease.…”

Myelin

“…This protein (referred to as the P1 protein when present in the PNS) can produce EAE when it is isolated and injected into rabbits, monkeys, or guinea pigs (Kiyota and Egami, 1972;. However, when intact PNS myelin itself is injected into rabbits or monkeys (Brostoff et al, , 1974bWisniewski et al, 1974), there is no evidence of EAE but only of lesions typical of EAN. Guinea pigs, on the other hand, develop CNS lesions in response to PNS myelin .…”