Recurrent Familial Digital Fibrokeratoma: A Case Report

Hao, Xingpei; Mirkin, Gene; Baglio, Robert J.

doi:10.1053/j.jfas.2019.01.010

Cited by 2 publications

(4 citation statements)

References 19 publications

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“…The etiopathogenesis of digital fibrokeratomas is not well elucidated, but converging data of literature suggest trauma and local infection to Staphylococcus aureus as triggering factors driving fibroblast proliferation 1,4,7,8,12 . In our systematic review, only eight participants reported trauma preceding lesion occurrence 2,10,17,22 and one patient developing fibrokeratoma after an episode of staphylococcal paronychia 12 .…”

Section: Discussionmentioning

confidence: 86%

“…Out of 66 individuals, nine patients failed previous surgical procedures, including three following shaving, 4,9 three after nonspecific surgical excision 4,6,10 (no histopathologic report available), and three treated with complete surgical excision 9 (with histopathologic proof of negative margin). Lack of response was seen in three patients following nonsurgical treatment, namely keratolytic ointment, 11 antibiotic course, 12,13 and silver nitrate 12…”

Section: Resultsmentioning

confidence: 99%

“…The calculated rates were observed for a mean time of follow‐up of 12.1 months (1–144). Interestingly, six patients who reported having previous treatments with recurrence were then successfully treated with complete surgical excision 4,9 . Therefore, complete surgical excision may represent the optimal treatment of acquired fibrokeratoma, with lower recurrence rate.…”

Section: Discussionmentioning

confidence: 99%

“…(1977) to describe identical histological lesions adjacent to the nail, a variant of Steel's garlic‐clove fibroma 2,3 . Classically, they present as an asymptomatic solitary flesh‐colored tumor with a slightly hyperkeratotic tip 3–5 . They typically emerge from the proximal nail fold or directly from the nail bed and grow into a branching, dome‐like, verrucous or rod‐shaped mass 6 .…”

Section: Introductionmentioning

confidence: 99%

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Acquired ungual fibrokeratoma: a systematic review of the literature

et al. 2020

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Background Acquired ungual fibrokeratomas (AUFKs) are benign recurrent fibrokeratotic tumors of the nail unit of uncertain etiology. Little is known about the optimal modality to successfully treat these lesions. No systematic review addressing ungual fibrokeratomas has been published to date. Objectives The aim of this study is to summarize all the published data regarding diagnostic and therapeutic challenges of AUFKs. Methods On August 9, 2019, a systematic search of Medline and Cochrane databases was conducted. All the studies describing the treatment of ungual fibrokeratomas, procedure description, pathological findings, outcome, and follow‐up period were included in this review. Results After full‐text article review, 103 articles were included, representing a total of 78 lesions. The commonly used treatments for fibrokeratomas were complete tumor resection (90.5%), shave excision (8.3%), and cryotherapy (1.2%). Complete surgical excision yielded the highest cure rate among all treatment modalities (90.8%) compared to partial surgical excision (28.6%) and cryotherapy (0%). The mean follow‐up period was 12.1 months (1–144). Conclusion Complete surgical removal preserving the matrix showed the highest cure rates and should be considered as first‐line treatment for AUFKs. Future adequately designed randomized control trials are warranted to compare different treatment modalities.

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Section: Discussionmentioning

confidence: 86%