Recurrent gastric cancer metastasizing to the bone marrow: A case report of a rare presentation

Gastric cancer is the third leading cause of cancer deaths worldwide. Disseminated carcinomatosis of bone marrow (DCBM) originating from gastric cancer is rare and associated with poor prognosis. We present the first reported case of gastric adenocarcinoma with DCBM leading to concomitant disseminated intravascular coagulation (DIC) and adrenal crisis refractory to treatment. Computerized tomography of the chest, abdomen and pelvis showed diffuse sclerosis of the axial and proximal appendicular skeleton, suggestive of metastatic disease. Bone marrow biopsy demonstrated infiltrative signet ring cells, consistent with metastatic adenocarcinoma from gastric primary. Laboratory tests showed severe anemia, thrombocytopenia, and coagulopathy, compatible with DIC.

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“…DCBM is often associated with hematologic disorders such as DIC, leukoerythroblastosis, or hemolytic anemia 4,6,9 .…”

Section: Discussionmentioning

confidence: 99%

Adrenal Crisis and Disseminated Intravascular Coagulation Associated With Disseminated Carcinomatosis of the Bone Marrow From Gastric Cancer

Lee

Goldberg

Malysz

et al. 2021

Preprint

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“…Gastric cancer is an important public health challenge as the fourth most common cancer and the second cause of cancer mortality worldwide [2]. Surgical resection is the mainstay of treatment for gastric cancer [3]. While Patients with HIV infections more often present with a specific malignancy, such as Kaposi's sarcoma and non-Hodgkin lymphomas [4].…”

Section: Introductionmentioning

confidence: 99%

A Patient with an Extended Window Period of AIDS Complicated with Gastric Cancer

2018

IJCRT

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This report describes a case of a postoperative gastric cancer patient with AIDS whose window period is extremely longer than normal. The patient suffered from recurrent pulmonary infection after operation. Multiple and Broadspectrum antibiotic was employed but the curative effect was not satisfying. Occurrence of anemia made the disease much more complicated, and the patient was finally diagnosed AIDS. We analyze the factors that may prolong the window period. Because the postoperative gastric cancer patient are susceptible to infection, which caused by poor nutrition status and immune compromise, it is easy to overlook the possibility of AIDS. And we found TCM treatment of AIDS has been an unexpected result in this patient.

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Paraneoplastic hypocalcemia in a patient whit gastric cancer accompanied by osteoblastic metastasis

et al. 2020

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Paraneoplastic syndromes are generally defined as clinical disorder associated with malignant diseases, and hypocalcemia as paraneoplastic manifestation associated with cancer is a rare condition. In patient with bone metastatic cancer, osteolytic lesions are more common than osteoblastic ones which give rise to hypercalcemia and hypocalcemia is a rare condition in this group of patients. We described a 56-year-old male with the history of gastric cancer and gastrectomy and chemotherapy since one year ego who came to clinic with complaints of nausea, vomiting and paresthesia of extremities which after diagnostic work up, paraneoplastic hypocalcemia was diagnosed. Hypocalcemia following bone metastasis is not a common phenomenon, but in patients with the history of gastric cancer and neurological symptoms (paresthesia, …) evaluation of serum calcium value is recommended.

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Recurrent gastric cancer metastasizing to the bone marrow: A case report of a rare presentation

Cited by 4 publications

References 17 publications

Adrenal Crisis and Disseminated Intravascular Coagulation Associated With Disseminated Carcinomatosis of the Bone Marrow From Gastric Cancer

Adrenal Crisis and Disseminated Intravascular Coagulation Associated With Disseminated Carcinomatosis of the Bone Marrow From Gastric Cancer

A Patient with an Extended Window Period of AIDS Complicated with Gastric Cancer

Paraneoplastic hypocalcemia in a patient whit gastric cancer accompanied by osteoblastic metastasis

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