Recurrent Guillain-Barre Syndrome in Japan.

Abstract

The clinical profiles of ll Japanese patients with recurrent episodes of Guillain-Barre syndrome (GBS), including 3 of our cases out ofa total of76 patients (48 males and 28 females), are reviewed. The recurrence rate was estimated as 4 %. Among the ll Japanese patients, 10 were male. Various viral infections had been confirmed in 1 case. No patients showed recurrent ophthalmoplegia. Sensory involvement varied from one episode to the next. These findings suggest the changing distribution of the demyelinating lesions and possibly a different reaction to the unknown pathogens in the recurrence of GBS. (Internal

Ten-Year Prospective Study (Clinical Spectrum) of Childhood Guillain-Barré Syndrome in the Arabian Peninsula: Comparison of Outcome in Patients in the Pre— and Post—Intravenous Immunoglobulin Eras

“…The relapse in Guillain-Barré syndrome has been seen with both intravenous immunoglobulin and plasmapheresis. 29,30 The acute relapses may respond to the repeat doses of intravenous immunoglobulin, as was seen in four of our cases, or there may be relentless progression, needing respiratory support. 27 Although there were initial reports of more relapse with one mode of treatment compared with the other, Hughes, in his editorial on the use of intravenous immunoglobulin, plasmapheresis, and plasmapheresis followed by intravenous immunoglobulin in randomly selected 383 patients divided into three groups, stated that the outcome was similar in all three groups after 4 weeks of initial treatment.…”

Prospective study of children with Guillain-Barre syndrome

“…More than one relapse and late onset relapse , 4-6 weeks after IVIG treatment suggest recurrent GBS. 19,20 The acute relapses may respond to the repeat doses of IVIG as was seen in 5 of the present cases or there may be relentless progression needing respiratory support. The authors recommend repeating IVIG at 400 mg per Kg once daily for 3 days at the earliest signs of relapse.…”

Recurrence of childhood Guillain-Barré syndrome as a pharyngeal-cervical-brachial variant: A case report

“…In reported groups of recurrent GBS, patients often experienced the same pattern in a recurrence [4,5,11,12]. However, sensory involvement varied from one episode to the next on 11 Japanese patients with recurrent episodes of GBS [13]. Although a patient with GBS manifested tetraplegia at onset and PCB in the recovery phase has been described [14].…”