Background: To investigate the feasibility, safety and therapeutic efficacy of arthroscopy in managing the 3 most common soft-tissue complications, peripatellar impingement (PI), arthrofibrosis (AF) and generalized synovitis (GS), after total knee arthroplasty (TKA). Methods: A retrospective review of patients undertaking arthroscopy for PI, AF and GS was conducted. Outcome measures included complications, postoperative range of motion (ROM), Knee Society Score (KSS), and rates of symptom recurrence, prosthesis revision. Intraoperative findings and surgical procedures were also recorded. Paired t test, Fisher’s exact test, Kruskal-Wallis test and post hoc analysis with Bonferroni correction were used for statistical evaluation.Results: A total of 74 patients, including 35 patients with peripatellar impingement, 25 patients with arthrofibrosis and 14 patients with generalized synovitis, with a mean age of 66.1±7.9 years, were analysed. The mean follow-up (FU) duration was 81.3±40.6 months. All patients underwent arthroscopic surgery safely without intraoperative complications. However, there were 4 postoperative complications, including 1 acute myocardial infarction and 3 periprosthetic joint infections. Overall, patients acquired improvements in ROM from 81.7±23.1° to 96.8±20.5° (p <0.05), in KSS knee score from 64.2±9.6 to 78.7±12.1 (p <0.05), and in KSS function score from 61.1±7.4 to 77.3±12.2 (p <0.05) postoperatively. Patients in all 3 groups had improvements in ROM (p <0.05), KSS knee score (p <0.05) and KSS function score (p <0.05). The overall recurrence rate was 22.9% (95% confidence interval (CI) 15.1%-34.9%), and the overall revision rate was 14.9% (95% CI 8.6%-25.6%). There were significant differences in both the symptom recurrence and prosthesis revision rates among the groups (p<0.05). The PI group had a significantly lower symptom recurrence rate (11.4%, 95% CI 4.5%-28.7%) and revision rate (8.6%, 95% CI 2.9%-25.3%) (p <0.017), while the GS group had a significantly higher recurrence rate (42.9%, 95% CI 23.4%-78.5%) and revision rate (35.7%, 95% CI 17.6%-72.1%) (p <0.017). Conclusions: In the setting of symptomatic TKA, although carrying certain risks for PJI and other complications, arthroscopic intervention could be feasible and provide clinical improvement in most cases at an average of 81.3 months follow-up. Patients with PI had the best outcomes, while patients with GS had the worst outcomes.Level of evidence: Level IV