Recurrent Herpes Simplex Virus 2 Lymphocytic Meningitis in Patient with IgG Subclass 2 Deficiency

Goyal, Tanvi; Ali, Imran

doi:10.3201/eid2604.190406

Cited by 3 publications

(2 citation statements)

References 13 publications

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“…23 Whole exome sequencing in patients with recurrent HSV2 meningitis has detected rare genetic variants related to ubiquitin proteasome, autophagy, and cell proliferation pathways, suggesting that affected patients may have an underlying immune defect. 24,25 Varicella Zoster Virus (VZV)…”

Section: Herpes Simplex Virus 2 (Hsv2)mentioning

confidence: 99%

Neurology of Acute Viral Infections

Krett

Beckham

Tyler

et al. 2022

The Neurohospitalist

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As specialists in acute neurology, neurohospitalists are often called upon to diagnose and manage acute viral infections affecting the nervous system. In this broad review covering the neurology of several acute viral infections, our aim is to provide key diagnostic and therapeutic pearls of practical use to the busy neurohospitalist. We will review acute presentations, diagnosis, and treatment of human herpesviruses, arboviruses, enteroviruses, and some vaccine-preventable viruses. The neurological effects of coronaviruses, including COVID-19, are not covered in this review.

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Section: Herpes Simplex Virus 2 (Hsv2)mentioning

confidence: 99%

Neurology of Acute Viral Infections

Krett

Beckham

Tyler

et al. 2022

The Neurohospitalist

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“…HSV2 has also been shown to be a major cause of recurrent lymphocytic meningitis (also referred to as Mollaret meningitis) [ 47 •]. Recent work has identified specific genetic variants associated with altered immune signaling pathways in patients with recurrent HSV2 meningitis, which may explain why these patients are predisposed to recurrent CNS reactivation [ 48 ]. The current treatment recommendation for HSV2 meningitis is IV acyclovir (5–10 mg/kg every 8 hours) until clinical improvement is observed followed by high-dose oral valacyclovir (1 g three times a day) for a total duration of antiviral treatment of 10–14 days [ 49 ].…”

Section: Herpes Simplex Virusmentioning

confidence: 99%

Herpesvirus-Associated Encephalitis: an Update

et al. 2022

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Purpose of Review Herpesviruses are a leading cause of encephalitis worldwide. The article reviews the eight human herpesviruses with a focus on recent advances as they pertain to encephalitis. Recent Findings Notable recent updates include the development of multiplex polymerase chain reaction (PCR)-based panels, which have improved access to PCR tests, especially in rural and resource-limited areas. Despite unchanged treatment recommendations, research is ongoing into novel therapies. There have been recent advances in vaccines, particularly for varicella zoster virus (VZV) which may impact neurologic complications. Finally, the recent discovery of an association between herpes encephalitis and post-infectious autoimmune encephalitis has had a critical impact on the fields of infectious and autoimmune neurology, though there remains much to learn. Summary Most herpesviruses are neurotropic and must be considered on the differential diagnosis for infectious encephalitis. This article describes recent advances in the diagnosis, treatment, complications, and management of these infections.

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Recurrent Benign Lymphocytic Meningitis Due to HSV-2: A Case Report

Ahmad¹,

Alsaeed²

2023

Dr. Sulaiman Al Habib Med J

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Recurrent benign lymphocytic meningitis (RBLM) is an uncommon form of aseptic meningitis characterized by the recurrence of meningeal symptoms followed by spontaneous recovery. Historically, RBLM has been attributed to herpes simplex virus (HSV) type 2 infection. Diagnosis is traditionally confirmed by PCR of viral DNA isolated from the CSF. Although the disease course is usually benign, antiviral therapy may benefit some patients. Here, we report the case of a young woman diagnosed with four episodes of aseptic meningitis within 10 years. The presence of HSV type 2 in the CSF was confirmed using PCR in three of the episodes. After the resolution of acute attacks, the patient was symptom-free with no neurological sequelae.

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Recurrent Herpes Simplex Virus 2 Lymphocytic Meningitis in Patient with IgG Subclass 2 Deficiency

Cited by 3 publications

References 13 publications

Neurology of Acute Viral Infections

Neurology of Acute Viral Infections

Herpesvirus-Associated Encephalitis: an Update

Recurrent Benign Lymphocytic Meningitis Due to HSV-2: A Case Report

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