Recurrent herpes simplex virus ocular infection: epidemiological and clinical features.

Pediatric Herpes Simplex Virus Keratitis

“…The recurrence rate in children was also higher in previous reports [3][4][5][6][7][8] (Table 2) than one would expect in a similar cohort of adults. 1,[15][16][17][18][19] On the basis of the Kaplan-Meier estimator, median recurrence time (ie, the time needed for an ocular recurrence to develop in 50% of patients) was 47 months of follow-up in our study; in contrast to the 12 months of followup found by Chong et al 8 Two possible reasons may explain why the recurrence interval in our study is longer. First, although the recurrence rate (45%) in our study was similar to that in Chong et al (48%), our follow-up time was much longer (3.2 years versus 1.1 years), which might make the recurrence interval in our study much longer.…”

“…However, unlike their study, 8 in this study the female gender was significantly associated with recurrence. Most studies [15][16][17][18][19] found no gender association with the recurrence of HSV keratitis, but the study of Wilhelmus et al 20 showed that more men than women experienced recurrent keratitis. A larger and more detailed The inflammatory response during HSV stromal keratitis leads to stromal scarring and opacification and is more severe in children than adults.…”

The Epidemiology of Herpes Simplex Virus Eye Disease in Northern California

“…This is consistent with results from prior studies, which also found no seasonal variation. 3,5,6,8 Our study found that the age-stratified incidence of ocular HSV increased after 45 years of age and was greatest over the age of 75 years. This finding is consistent with the recent Olmstead County study, which observed an increase in the incidence of new cases with aging, peaking in the ninth decade of life at 28 cases per 100,000 people.…”

“…Most studies that examined the incidence, prevalence, and manifestations of ocular HSV were published a number of years ago. [3][4][5][6][7][8] The annual incidence of new ocular HSV infections in the United States was recently estimated at 11.8 per 100,000 people, 9 slightly higher than the incidence of 8.4 per 100,000 people found over 2 decades ago in a similar population. 7 Labetoulle in 2005 prospectively surveyed French ophthalmologists and reported an incidence of 13.2 cases of herpetic keratitis per 100,000 person-years.…”

Valacyclovir for the prevention of recurrent herpes simplex virus eye disease after excimer laser photokeratectomy

“…[4][5][6][7][8][9][10][11][12][13][14][15][16] It is estimated that by the year 2000, nearly 1 million laser procedures for vision correction will be performed per year in the United States. 6 In addition, the excimer laser has been used to remove superficial scars and to smooth corneal irregularities in abnormal comeas by phototherapeutic keratectomy (PTK).…”