Recurrent Herpes Simplex Virus Type 1 (HSV-1) Infection Modulates Neuronal Aging Marks in In Vitro and In Vivo Models

Napoletani, Giorgia; Protto, Virginia; Marcocci, Maria Elena; Nencioni, Lucia; Palamara, Anna Teresa; Chiara, Giovanna De

doi:10.3390/ijms22126279

Cited by 17 publications

(13 citation statements)

References 60 publications

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“…In addition, because the brain is an organ with immune privilege, meaning that the immune system has limited access to this tissue, even foreign antigens do not generally trigger an immune response in this organ [ 25 ]. Thus, the ability of SARS-CoV-2 to replicate in the brain of some patients, could lead to a long-term reservoir of the virus which could promote the development of chronic neurodegenerative diseases, similar to what has been shown for herpes viruses [ 26 ]. These possibilities should be validated in prospective studies from COVID-19 recovered patients.…”

Section: The Biology Of Sars-cov-2mentioning

confidence: 99%

The potential role of COVID-19 in the induction of DNA damage

Pánico

Ostrosky‐Wegman

Salazar

2022

Mutation Research/Reviews in Mutation Research

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The coronavirus disease-2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is challenging global health and economic systems. In some individuals, COVID-19 can cause a wide array of symptoms, affecting several organs, such as the lungs, heart, bowels, kidneys and brain, causing multiorgan failure, sepsis and death. These effects are related in part to direct viral infection of these organs, immunological deregulation, a hypercoagulatory state and the potential for development of cytokine storm syndrome. Since the appearance of COVID-19 is recent, the long-term effects on the health of recovered patients remain unknown. In this review, we focused on current evidence of the mechanisms of DNA damage mediated by coronaviruses. Data supports that these viruses can induce DNA damage, genomic instability, and cell cycle deregulation during their replication in mammalian cells. Since the induction of DNA damage and aberrant DNA repair mechanisms are related to the development of chronic diseases such as cancer, diabetes, neurodegenerative disorders, and atherosclerosis, it will be important to address similar effects and outcomes in recovered COVID-19 patients.

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Section: The Biology Of Sars-cov-2mentioning

confidence: 99%

The potential role of COVID-19 in the induction of DNA damage

Pánico

Ostrosky‐Wegman

Salazar

2022

Mutation Research/Reviews in Mutation Research

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“…In response to immunosuppression, peripheral infection, and inflammation, HSV-1 reactivates, creating a combination of viral action and inflammatory effects that are poorly repaired by APOE-ε4 carriers, ultimately leading to the development of AD ( Itzhaki, 2018 ). In addition, a recent study pointed out novel molecular mechanisms through which recurrent HSV-1 infection may affect neuronal aging, likely contributing to neurodegeneration ( Napoletani et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Multigenomics Reveals the Causal Effect of Herpes Simplex Virus in Alzheimer’s Disease: A Two-Sample Mendelian Randomization Study

Zhang

Luo

et al. 2022

Front. Genet.

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In recent years, the herpes virus infectious hypothesis for Alzheimer’s disease (AD) has gained support from an increasing number of researchers. Herpes simplex virus (HSV) is a potential risk factor associated with AD. This study assessed whether HSV has a causal relationship with AD using a two-sample Mendelian randomization analysis model. Six single-nucleotide polymorphisms (SNPs) associated with HSV-1 and thirteen SNPs associated with HSV-2 were used as instrumental variables in the MR analysis. We estimated MR values of relevance between exposure and the risk of AD using inverse-variance weighted (IVW) method, MR-Egger regression (Egger), and weighted median estimator (WME). To make the conclusion more robust and reliable, sensitivity analyses and RadialMR were performed to evaluate the pleiotropy and heterogeneity. We found that anti-HSV-1 IgG measurements were not associated with risk of AD (OR, 0.96; 95% CI, 0.79–1.18; p = 0.736), and the same was true for HSV-2 (OR, 1.03; 95% CI, 0.94–1.12; p = 0.533). The findings indicated that any HSV infection does not appear to be a genetically valid target of intervention in AD.

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“…HSV-1 production was performed as previously reported [48]. Briefly, monolayers of Vero cells in 75 cm 2 tissue culture flasks were infected with HSV-1 (strain F) at 0.01 MOI.…”

Section: Hsv-1 and Jcpyv Virion Productionmentioning

confidence: 99%

The Inhibition of DNA Viruses by the Amphibian Antimicrobial Peptide Temporin G: A Virological Study Addressing HSV-1 and JPCyV

Marcocci

Jackowska

Prezioso

et al. 2022

IJMS

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Herpes simplex virus type-1 (HSV-1) and John Cunningham polyomavirus (JCPyV) are widely distributed DNA viruses causing mainly asymptomatic infection, but also mild to very severe diseases, especially when these viruses reach the brain. Some drugs have been developed to inhibit HSV-1 replication in host cells, but their prolonged use may induce resistance phenomena. In contrast, to date, there is no cure for JCPyV. The search for alternative drugs that can reduce viral infections without undermining the host cell is moving toward antimicrobial peptides (AMPs) of natural occurrence. These include amphibian AMPs belonging to the temporin family. Herein, we focus on temporin G (TG), showing that it strongly affects HSV-1 replication by acting either during the earliest stages of its life cycle or directly on the virion. Computational studies have revealed the ability of TG to interact with HSV-1 glycoprotein B. We also found that TG reduced JCPyV infection, probably affecting both the earliest phases of its life cycle and the viral particle, likely through an interaction with the viral capsid protein VP1. Overall, our results are promising for the development of short naturally occurring peptides as antiviral agents used to counteract diseases related to HSV-1 and JCPyV.

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Recurrent Herpes Simplex Virus Type 1 (HSV-1) Infection Modulates Neuronal Aging Marks in In Vitro and In Vivo Models

Cited by 17 publications

References 60 publications

The potential role of COVID-19 in the induction of DNA damage

The potential role of COVID-19 in the induction of DNA damage

Multigenomics Reveals the Causal Effect of Herpes Simplex Virus in Alzheimer’s Disease: A Two-Sample Mendelian Randomization Study

The Inhibition of DNA Viruses by the Amphibian Antimicrobial Peptide Temporin G: A Virological Study Addressing HSV-1 and JPCyV

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