Recurrent<i>Bordetella holmesii</i>Bacteremia and Nasal Carriage in a Patient Receiving Rituximab

Ngũyen, Liem Binh Luong; Epelboin, Loïc; Gabarre, Jean; Lecsö, Marylin; Guillot, Sophie; Bricaire, François; Caumes, Éric; Guiso, Nicole

doi:10.3201/eid1910.130345

Cited by 17 publications

(8 citation statements)

References 9 publications

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“…However, no real difference of lipid A structure was observed between isolates from blood or respiratory origins which correlates with data from other studies [18,19]. This also correlates with the fact that, in cases of bacteremia, nasal carriage should be assessed as shown in a previous study [13]. …”

Section: Discussionsupporting

confidence: 89%

Bordetella holmesii: Lipid A Structures and Corresponding Genomic Sequences Comparison in Three Clinical Isolates and the Reference Strain ATCC 51541

Bouchez

Albitar-Nehme

Новиков

et al. 2017

IJMS

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Bordetella holmesii can cause invasive infections but can also be isolated from the respiratory tract of patients with whooping-cough like symptoms. For the first time, we describe the lipid A structure of B. holmesii reference strain ATCC 51541 (alias NCTC12912 or CIP104394) and those of three French B. holmesii clinical isolates originating from blood (Bho1) or from respiratory samples (FR4020 and FR4101). They were investigated using chemical analyses, gas chromatography–mass spectrometry (GC–MS), and matrix-assisted laser desorption ionization–mass spectrometry (MALDI–MS). The analyses revealed a common bisphosphorylated β-(1→6)-linked d-glucosamine disaccharide with hydroxytetradecanoic acid in amide linkages. Similar to B. avium, B. hinzii and B. trematum lipids A, the hydroxytetradecanoic acid at the C-2′ position are carrying in secondary linkage a 2-hydroxytetradecanoic acid residue resulting of post-traductional biosynthesis modifications. The three clinical isolates displayed characteristic structural traits compared to the ATCC 51541 reference strain: the lipid A phosphate groups are more or less modified with glucosamine in the isolates and reference strain, but the presence of 10:0(3-OH) is only observed in the isolates. This trait was only described in B. pertussis and B. parapertussis strains, as well as in B. petrii isolates by the past. The genetic bases for most of the key structural elements of lipid A were analyzed and supported the structural data.

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Section: Discussionsupporting

confidence: 89%

Bordetella holmesii: Lipid A Structures and Corresponding Genomic Sequences Comparison in Three Clinical Isolates and the Reference Strain ATCC 51541

Bouchez

Albitar-Nehme

Новиков

et al. 2017

IJMS

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“…Relapse of bacteremia has rarely been reported. One patient was receiving rituximab and another patient had prosthetic valve endocarditis [15,20]. The clinical outcome of invasive disease is favorable and there were no mortalities reported in the literature.…”

Section: Discussionmentioning

confidence: 99%

“…A carbapenem was administered in 20% (n  6) of cases while amoxicillin/clavulanate was given in one case. One patient was noted to respond to ceftriaxone therapy despite in vitro testing results with MICs in the 'resistant' range [20]. It is also important to note that one patient with meningitis did not improve until she was switched to a carbapenem [11].…”

Section: Treatmentmentioning

confidence: 98%

InvasiveBordetella holmesiiinfections

Fishbain

Riederer

Sawaf

et al. 2014

Infectious Diseases

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Bordetella holmesii is a rare cause of invasive human disease. The fastidious and unusual nature of this organism makes routine isolation and identification challenging. We report two cases of B. holmesii bacteremia that were rapidly identified by matrix-assisted laser desorption-ionization time-of-flight mass spectrometry (MALDI-TOF MS) when standard techniques failed to provide speciation. There are no current standards for susceptibility testing or treatment recommendations. The rare occurrence and challenges in identifying this pathogen led us to perform a comprehensive review of the epidemiology, clinical presentations, and treatment options for this potentially invasive pathogen.

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“…Ces résultats ont été confirmés aux États-Unis [47]. Le portage de cette bactérie au niveau pharyngé a été récemment montré en France [48].…”

Section: Polymerase Chain Reaction Ou Pcr En Temps Réel (Pcr-tr)unclassified

“…Le groupe de travail antiinfectieux de l'Afssaps (GTA) et la commission d'AMM ont antérieurement validé le remplacement dans le traitement de la coqueluche de l'érythromycine par la josamycine, la clarithromycine et l'azithromycine [53,54]. Une expertise Cochrane incite à un choix préférentiel de ces deux dernières molécules [48]. Toutefois, les données récentes concernant la propension de l'azithromycine à sélectionner des mutants résistants [55], la forte émergence de souches de B. pertussis résistantes à l'azithromycine en Chine (dont un cas a été récemment observé en France, cf.…”

Section: Le Traitement Antibiotiqueunclassified