Recurrent Staphylococcus aureus abscess and fatal pneumococcal septicemia due to IRAK‐4 deficiency

Abstract

We describe the case of an infant with recurrent episodes of staphylococcal skin abscess and subsequent lethal pneumococcal meningitis/septicemia due to interleukin-1 receptor-associated kinase 4 (IRAK-4) deficiency. In this case, systemic signs of inflammatory response were poor and delayed. Among all other reported cases of IRAK-4 deficiency, none involved severe viral or fungal disease, and the range of infecting bacteria was narrow.

How we deal with Staphylococcus aureus (MSSA, MRSA) central nervous system infections

“…Gan et al [42] described a brain abscess caused by MRSA occurring in an otherwise healthy infant as a conjunctivitis complication. A patient suffering from brain abscess should always be investigated for immunodeficiency, and in case of infants also for specific congenital immune deficits [43]. Epidural spinal abscesses can compress the spinal cord and nerve roots, resulting in motor and sensory lateralized deficits.…”