Recurrent implantation failure: which patients benefit from endometrial scratching prior to IVF?

Bar, Guy; Harlev, Avi; Alfayumi‐Zeadna, Samira; Zeadna, Atif; Bord, Ilia; Har-Vardi, Iris; Lunenfeld, Eitan; Levitas, Eliahu

doi:10.1007/s00404-019-05424-1

Cited by 19 publications

(15 citation statements)

References 27 publications

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“…The first study by Barash et al included RIF and non-RIF patients and found a two-fold increase in IR (27.7% vs. 14.2%, p = 0.00011), PR (66.7% vs. 30.3%, p = 0.00009), and LBR (48.0% vs. 23.6%, p = 0.016) in those patients who underwent four endometrial injuries during the cycle prior to the embryo transfer [ 2 ]. Similar results were obtained by other authors who performed several injuries to their patients [ 6 ], but also by authors who performed a single injury [ 3 , 4 , 22 ]. On the contrary, many other authors have not been able to find a difference either with one or more ES [ 5 , 23 , 24 ].…”

Section: Discussionsupporting

confidence: 90%

“…Most studies have included a control group with no intervention [ 4 , 13 ], but some others have considered those undergoing a mock technique (such as a cervical pipelle inserted into the cervix), or a previous hysteroscopy [ 26 ] as control patients, which may have caused some kind of endometrial damage as well and could be considered a bias [ 23 ]. Regarding the target population of studies, some authors have included only first IVF cycles [ 4 , 27 ], some others only RIF patients [ 2 , 6 , 23 , 28 ], and others all patients without distinction [ 13 , 29 ], obtaining diverse results. Finally, the number of patients included in studies is very different as some studies had a low number of patients recruited [ 23 ], or were terminated before completion [ 29 , 30 , 31 ].…”

Section: Discussionmentioning

confidence: 99%

“…Several studies were conducted after that and some authors reached the same conclusions [ 3 , 4 ], but others did not [ 5 ]. When only patients with recurrent implantation failure (RIF) were considered, ES seemed to have a better impact on the outcomes [ 6 ], as the review by Potdar et al [ 7 ] and the Cochrane review by Nastri et al showed in their results [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Is Endometrial Scratching Beneficial for Patients Undergoing a Donor-Egg Cycle with or without Previous Implantation Failures? Results of a Post-Hoc Analysis of an RCT

Izquierdo¹,

Fuente²,

Spies³

et al. 2021

Diagnostics

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Endometrial scratching (ES) has been proposed as a useful technique to improve outcomes in in vitro fertilization (IVF) cycles, particularly in patients with previous implantation failures. Our objective was to determine if patients undergoing egg-donor IVF cycles had better live birth rates after ES, according to their previous implantation failures. Secondary outcomes were pregnancy rate, clinical pregnancy rate, ongoing pregnancy rate, miscarriage rate, and multiple pregnancy rate. We analysed the results of 352 patients included in the Endoscratch Trial (NCT03108157). A total of 209 were patients with one or no previous implantation failures (105 with an ES done in the previous cycle, group A1, and 104 without ES, group B1), and 143 were patients with at least two previous failed implantations (71 patients with ES, group A2, and 72 without ES, group B2). We found an improvement in pregnancy rates (62.9% in group A1 vs. 55.8% in group B1 vs. 70.4% in group A2 vs. 76.4% in group B2, p = 0.028) in patients with at least two previous implantation failures, but this difference was not statistically different when we compared clinical pregnancy rates (59.1% vs. 51.0% vs. 64.8% vs. 68.1% in groups A1, B1, A2 and B2, respectively, p = 0.104) and live birth rates (52.4% vs. 43.3% vs. 57.8% vs. 55.6% in groups A1, B1, A2 and B2, respectively, p = 0.218). According to these results, we conclude that there is no evidence to recommend ES in egg-donor IVF cycles, regardless of the number of previous failed cycles.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Is Endometrial Scratching Beneficial for Patients Undergoing a Donor-Egg Cycle with or without Previous Implantation Failures? Results of a Post-Hoc Analysis of an RCT

Izquierdo¹,

Fuente²,

Spies³

et al. 2021

Diagnostics

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“…In addition, there were significantly higher biochemical and clinical pregnancy rates when FBT was performed within 120 days of HSC-P. This could be due to a combination of the corrected uterine pathology, and a potentially beneficial effect induced by the endometrial trauma of HSC-P, similar to those of endometrial scratching [41][42][43][44]. However, the extent of this beneficial effect is uncertain, as some researchers have suggested that the benefits of endometrial scratching are lost after one menstrual cycle [45,46].…”

Section: Plos Onementioning

confidence: 99%

Optimal time interval between hysteroscopic polypectomy and frozen-thawed blastocyst transfer: A retrospective study

Yang

Chen

et al. 2020

PLoS ONE

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The optimal timing of frozen-thawed blastocyst transfer following hysteroscopic polypectomy is an important and unanswered clinical question. In this study, we conducted a retrospective survey of cases from an infertility center at an academic hospital. We reviewed the charts of all patients who received in-vitro fertilization and frozen-thawed blastocyst transfers (FBT) at the center from January 2009 to November 2019. One hundred and two patients with prior diagnosis of endometrial polyp that were treated with hysteroscopic polypectomy before received their first FBT at the center were identified as cases. Patients without prior diagnosis of endometrial polyp, and who received their first FBT at the center were defined as controls. Controls were enrolled at a 1-to-1 ratio to the cases. The cases and controls did not show differences in baseline characteristics, endometrial thickness, or the number of good blastocysts transferred. The clinical pregnancy rates and live birth rates were similar. Regarding the optimal interval between polypectomy and FBT, a cutoff of 120 days was identified from the ROC curve. A stratified analysis showed that when FBT was performed within an interval of 120 days after polypectomy, there were higher biochemical pregnancy rates (73.2%, 45.2%; OR 3.3; P = .007) and clinical pregnancy rates (64.8%, 41.9%; OR 2.54; P = .032), when compared with intervals greater than 120 days. There were no significant differences in implantation and live birth rates. In conclusion, pregnancy rates following FBT in patients who had received prior endometrial polypectomy were comparable to pregnancy rates after FBT in patients without endometrial polyp. Subgroup analysis showed that an interval greater than 120 days between hysteroscopic polypectomy and FBT was associated with decreased pregnancy rates. Patients who wish to receive embryo transfer after polypectomy should wait no longer than 120 days.

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“…Yakın zamanda yayınlanan retrospektif bir çalışmada en az iki IVF siklusu sonrası (ortalama 4,5 siklus) açıklanamayan tekrarlayan implantasyon başarısızlığı olan olgularda IVF öncesi geç proliferatif ve orta luteal fazda pipelle endometrial hasar oluşturmanın uygulama yapılmayan kontrollere göre klinik gebelik ve canlı doğum oranlarında anlamlı oranda artışla ilişkili bulunduğu ve uygulamanın gebelik oluşması üzerine bağımsız bir faktör olabileceği öne sürülmüştür. Araştırıcılar bulgularının geniş bir prospektif randomize çalışma ile doğrulanması gerektiğini de vurgulamışlardır (12).…”

Section: H/s Ve Endometrial Biyopsi Sonuçlarıunclassified

Diagnostik histeroskopi ve endometrial biyopsi ile embriyo transferi arası geçen süre gebelik sonuçları üzerine etkili midir?

et al. 2021

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Amaç: In vitro fertilizasyon öncesi diagnostik histeroskopi ve endometrial hasar oluşturmanın etkinliği birçok çalışmada araştırılmıştır ve sonuçlar tartışmalıdır. Prosedürler arası optimal zaman aralığı ve optimal endometrial hasar oluşturma tekniği de net olarak tanımlanmamıştır. Bu çalışmanın amacı histeroskopi/endometrial biyopsi ile embriyo transferi arası zaman aralığının reprodüktif sonuçlar üzerine etkisini araştırmaktır. Gereç ve Yöntem: 2016-2018 yılları arasında, in vitro fertilizasyon siklusu öncesinde diagnostik histeroskopiyle birlikte endometrial biyopsi yapılan olgular retrospektif olarak analiz edildi. Hastalar prosedürler arası süreye göre beş gruba ayrıldı. Grupların reprodüktif sonuçları olarak klinik gebelik, gebelik kaybı ve canlı doğum oranları analiz edildi. Bulgular: Toplamda 252 hasta analize alındı, %49,2'si tekrarlayan implantasyon başarısızlığı olan olguları içeriyordu. Embriyo transfer siklusu olguların %29'unda histeroskopi/endometrial biyopsi prosedüründen 1 ay sonra, %32'sinde 2 ay sonra, %17,5'unda 3-4 ay sonra, %12'sinde 5-6 ay sonra ve %9,5'unda 6 aydan daha geç sürede uygulandı. Grupların temel karakteristikleri farklılık göstermiyordu. Grupların klinik gebelik (%34,

show abstract

Recurrent implantation failure: which patients benefit from endometrial scratching prior to IVF?

Cited by 19 publications

References 27 publications

Is Endometrial Scratching Beneficial for Patients Undergoing a Donor-Egg Cycle with or without Previous Implantation Failures? Results of a Post-Hoc Analysis of an RCT

Is Endometrial Scratching Beneficial for Patients Undergoing a Donor-Egg Cycle with or without Previous Implantation Failures? Results of a Post-Hoc Analysis of an RCT

Optimal time interval between hysteroscopic polypectomy and frozen-thawed blastocyst transfer: A retrospective study

Diagnostik histeroskopi ve endometrial biyopsi ile embriyo transferi arası geçen süre gebelik sonuçları üzerine etkili midir?

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