Recurrent intracranial meningioma with multiple pulmonary metastases: A case report

Abstract

Meningiomas are slow-growing tumors, which are generally considered to be benign and rarely metastasize. Although cases of extracranial metastatic meningioma have previously been reported, multiple pulmonary metastases from a benign intracranial meningioma is particularly rare. In the present report, a case of recurrent transitional meningioma with multiple lung nodules, which were demonstrated to be metastatic meningioma, is presented. A 54-year-old female patient received surgical resection of the tumor located in the left base of the middle cranial fossa in 2006. Post-surgery pathological examination indicated a transitional meningioma of World Health Organization grade I. The tumor recurred at the original site 1 year and 3 months later and was completely surgically removed once again. Radiotherapy was administered following the second surgery. Gamma Knife was used to remove the recurrent tumor 18 months following the second surgery. Simultaneously, a chest computed tomography scan revealed multiple pulmonary nodules, which were demonstrated to be metastatic meningioma following wedge resection of the superior lobe of the right lung. The clinical behavior of meningioma does not always correlate with the classification of meningioma. A higher rate of cellular proliferation is not essential for extracranial metastasis, and an individual meningioma of any type may metastasize. Comprehensive examinations should be performed for patients with a history of recurrent intracranial meningioma to detect any distant metastases as early as possible, even when the primary tumor is benign.

Lung metastases from intracranial bleeding meningioma

“…Intracranial neoplasms accompanying spontaneous hemorrhage are accounting for 1.4% to 10% of all intracranial neoplasms, among them, the intratumoral hemorrhage of meningioma is extremely rare (only 0.5%–2.4%). [ 3 ] Meanwhile, the extracranial metastasis of benign meningioma is particularly rare [ 2 ] , and clinical information including radiological and pathological features of its extracranial metastasis are not well characterized. Therefore, our case was unusual since it was a primary meningioma with intratumoral bleeding and presented lung metastases simultaneously.…”

“…The metastatic lesions are usually observed as single or multiple round, various sizes, well-defined and solid nodules. [ 2 ]…”

“…[ 1 ] Meningiomas are usually benign neoplasms and rarely metastasize with an incidence rate of 0.1%. [ 2 ] Intratumoral hemorrhage of meningioma is also uncommon. [ 3 ] However, to the best of our knowledge, concurrent occurrence of intratumoral hemorrhage and distal metastases with meningioma has seldom been reported.…”

Solitary pulmonary metastasis after meningioma surgery of the head: a case report

“…Although meningiomas are usually associated with a benign clinical course, they can sometimes show malignant behavior, such as distant metastasis. Although only a few cases of pulmonary metastasis of meningioma have been reported to date, the lungs have been described as the most frequent site of meningioma metastasis [ 2 ]. We herein report a unique and rare surgical case of metastatic meningioma presenting with solitary pulmonary metastasis 2 years after neurosurgical resection of the primary tumor.…”

Paraneoplastic symptoms caused by extracranial meningioma metastases?

“…[1345678101114151617] The incidence of extracranially metastasizing meningiomas seems to be less than 1:1000. [7] If distant metastases occur, they usually affect the lungs, bones, spinal canal, liver, or kidneys.…”