Recurrent intracranial solitary fibrous tumor with cerebrospinal fluid dissemination

Abstract

Solitary fibrous tumor (SFT) is a benign and rare neoplasm. To date, only 37 patients with intracranial SFTs have been reported. Although a number of the tumors were recurrent and some later underwent malignant transformation, none of these lesions progressed to cerebrospinal fluid (CSF) dissemination. In this paper the authors report a case of SFT in which the lesion recurred several times and ultimately was disseminated by the CSF. The patient was a 63-year-old woman with multiple intracranial and spinal tumors. Fifteen years before this presentation, at the age of 48 she had been hospitalized for resection of a falcotentorial tumor. During the ensuing 15 years she underwent multiple surgeries and sessions of radiation therapy for recurrent lesions. The exclusive location of her tumors in the subarachnoid space at the end of this 15-year period indicate CSF dissemination of the tumor. The tumor that was resected when the patient was 48 years old and the latest resected lesion were analyzed by performing immunohistological CD34, epithelial membrane antigen, vimentin, S100 protein, and reticulin staining, and determining the MIB-1 labeling index (LI). Most of the results were identical, and both tumors were diagnosed as SFT according to a staining pattern that showed a strong and diffuse positive reaction for CD34. Nevertheless, the authors noted that the MIB-1 LI increased from less than 1% in the original tumor to 13% in the latest tumor. The increased proliferation of MIB-1 indicates that the malignant transformation could have occurred during tumor recurrence with CSF dissemination.

Meningeal hemangiopericytomas and hemangiopericytoma/solitary fibrous tumors of extracranial soft tissues: a comparison

“…Multiple recurrences have led to regard meningeal HPC as a distinct entity from intracranial SFT. Nevertheless, in spite of the several statements that intracranial SFTs have a benign clinical behavior [10,21], there are many cases of intracranial SFT that have recurred and even manifested distant metastases [9,[22][23][24][25][26], as to indicate that the two conditions are clinically very similar.…”

Primary anaplastic solitary fibrous tumor of the tentorium cerebelli

“…These tumors were considered to have benign histopathological features at onset, and anaplastic or malignant transformation resulting from multiple recurrences has been reported in only four patients. [2][3][4][5] To our knowledge, a primary anaplastic variant of SFT has not been reported. Thus, we present a patient with a pathologically confirmed primary anaplastic SFT arising from the tentorium cerebelli (TC).…”

Solitary fibrous tumor of the tentorium – a case report

“…The chemotherapeutic agent Toremifene can also be administered if the proliferation rate is high (10). Recurrence and also malignant transformation have been reported in meningeal solitary fibrous tumors (6,11,16,20,21). Hakan et al, in their review, have come across a higher rate of recurrence in tentorial tumors that they have attributed to the incompleteness of resection (5).…”