Recurrent intraluminal eosinophilic tracheal granuloma in a Siberian husky

Adαmama-Moraitou, K. K.; Soubasis, Nektarios; Pardali, Dimitra; Psalla, Dimitra; Papazoglou, Lysimachos G.; Prassinos, N. N.; Anagnostou, Τ.; Rallis, Timoleon

doi:10.1080/01652176.2015.1021493

Cited by 5 publications

(5 citation statements)

References 28 publications

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“…Possible differential diagnoses for intraluminal tracheal nodules in dogs included parasites ( Oslerus osleri , Onchocerca species),3–5 primary and metastatic neoplasia (cartilaginous tumours such as osteochondroma, chondroma, chondrosarcoma; mast cell tumour, leiomyoma),6 7 eosinophilic granuloma,8 nodular hyperplastic tracheitis,9 nodular amyloidosis,10 tracheal papillomatosis11 and tracheobronchopathia osteochondroplastica 12…”

Section: Differential Diagnosismentioning

confidence: 99%

Complete resolution of diffuse inflammatory tracheal stenosis in a dog

Costa

Palma

Dennis

et al. 2020

Vet Record Case Reports

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A four-year-old female entire Weimaraner, recently diagnosed with epilepsy, was referred with a three-week history of coughing and lethargy. The dog had been diagnosed with aspiration pneumonia on thoracic radiographs, but the cough continued despite antibiotic therapy and an apparent improvement in the radiographic lung changes. CT of the thorax revealed a diffuse and severe nodular thickening of the tracheal wall. Tracheoscopy showed a thickened and irregular mucosa with multiple nodules causing segmental stenosis of the trachea. Histopathology of the nodular tracheal mucosa demonstrated severe, multifocal to diffuse neutrophilic inflammation. Once infectious and neoplastic causes were excluded, the dog was diagnosed with an inflammatory tracheitis of unknown aetiology. A tapering course of glucocorticoids was prescribed, which led to a complete clinical and endoscopic resolution of the coughing and tracheal lesions, respectively.

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Section: Differential Diagnosismentioning

confidence: 99%

Complete resolution of diffuse inflammatory tracheal stenosis in a dog

Costa

Palma

Dennis

et al. 2020

Vet Record Case Reports

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“…We are aware of a single case of suspected immunoglobulin G4‐related disease (IgG4‐RD) in a dog, which ultimately could not be confirmed . It is unclear if any of the eosinophilic granuloma cases previously reported in Husky dogs share a common pathogenesis with IgG4‐RD, but the cases do describe involvement of mass‐like lesions around the head or abdominal organs, fibroplasia and lymphoplasmacytic inflammation . Ours is the first reported case with clinical support for a diagnosis of IgG4‐RD in a dog.…”

Section: Discussionmentioning

confidence: 84%

Immunoglobulin G4‐related disease in a dog

Colopy¹,

Shiu²,

Snyder

et al. 2019

Veterinary Internal Medicne

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Immunoglobulin G4-related disease (IgG4-RD), which affects many organ systems, has been recognized as a distinct clinical entity in human medicine for just over a decade but has not been previously identified in dogs. In humans, IgG4-RD is characterized by diffuse IgG4-positive lymphoplasmacytic infiltrates that commonly lead to increased serum concentrations of IgG4 and IgE, peripheral eosinophilia, tumorous swellings that often include the parotid salivary glands, obliterative phlebitis, and extensive fibrosis. Herein we describe the diagnosis, clinical progression, and successful treatment of IgG4-RD in an 8-year-old female spayed Husky mixed breed dog.Immunoglobulin G4-related disease should be considered as a differential diagnosis for dogs with vague clinical signs, lymphoplasmacytic swellings, restricted polyclonal gammopathy, eosinophilia or some combination of these findings.

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“…or b.i.d. over a three-to four-week period is usually adequate to control clinical manifestations of the granulomas and strikingly, spontaneous remission has been also reported (Adamama-Moraitou et al 2015).…”

Section: Discussionmentioning

confidence: 98%

“…Dogs or cats of any age may be affected, although it is more common in dogs less than three years of age and predominately females (Sykes et al 2001;Wallace et al 2012). Rottweilers, Siberian Huskies and Alaskan Malamutes may be more likely to develop EP than other breeds (Moon 1992;Sykes et al 2001;Wallace et al 2012;Katajavuori et al 2013;Adamama-Moraitou et al 2015). It is possible that antigenic sources can trigger a hypersensitivity reaction, such as bacteria, fungi, parasites, inhaled allergens or drugs (Akuthota and Weller 2012) and neoplasia (Fina et al 2014).…”

mentioning

confidence: 99%

Pulmonary eosinophilic granulomatosis in a dog

Agudelo¹,

Stehlik²,

Filipejová³

et al. 2022

Vet. Med. - Czech

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A two-year-old female Prague Ratter dog was presented for evaluation of cough, exercise intolerance and worsening dyspnea. A previous treatment with antibiotics did not resolve the clinical signs. A diagnostic approach revealed peripheral eosinophilia, endoscopic bronchial changes, and bronchoalveolar lavage with eosinophilic inflammation. Thoracic radiographs revealed a solitary mass and bilateral interstitial lung pattern. These radiographic findings were confirmed by computed tomography and ultrasound-guided biopsy of the lung mass. Treatment with prednisolone and azathioprine was initiated. Two months afterwards, the granuloma was no longer detectable radiographically. All medication was gradually discontinued after nine months and currently, after almost three years, the dog remains free of clinical signs.

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Recurrent intraluminal eosinophilic tracheal granuloma in a Siberian husky

Cited by 5 publications

References 28 publications

Complete resolution of diffuse inflammatory tracheal stenosis in a dog

Complete resolution of diffuse inflammatory tracheal stenosis in a dog

Immunoglobulin G4‐related disease in a dog

Pulmonary eosinophilic granulomatosis in a dog

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