Recurrent laryngeal leiomyoma

Abstract

Leiomyoma-a benign smooth muscle tumor which is most commonly reported in uterus and gastrointestinal tract is rare in the upper aero-digestive tract due to the paucity of smooth muscle in the area. To the best of our knowledge, only 40 cases of leiomyoma occurring in larynx have been reported since 1966 in English literature. We report a case in a 18-year-old lady who presented with recurrent laryngeal leiomyoma which was confirmed by immunohistochemistry. The post-operative course was uneventful.

Laryngeal leiomyoma: a case report and literature review

“…Epithelioid leiomyomas manifest as tumor cell masses with round or oval nucleus, with or without vacuoles, and clear cell changes in the rich eosinophilic cytoplasm [4]. The common leiomyoma are characterized by intertwined spindle cells, cigar-shaped nuclei, eosinophilic cytoplasm, and a positive reaction to smoothmuscle actin or desmin [1]. The case we reported here is consistent with the pathological diagnosis of common leiomyomas.…”

“…They occur mostly in the uterus, small intestine and esophagus. In contrast, LMs occur rarely in the head and neck region due to the paucity of smooth muscle [1]. Three different types of leiomyoma are recognized: the common leiomyoma, the vascular leiomyoma (angiomyoma) and the epithelioid leiomyoma.…”

Laryngeal leiomyoma: A case report and review of literature

“…They mostly arise in the uterus, small intestine, and esophagus. By contrast, LMs rarely occur in the head and neck region because of the paucity of smooth muscle[ 1 ]. Three different types of LM are recognized: Common LM, vascular LM (angiomyoma), and epithelioid LM.…”

“…Epithelioid LMs manifest as tumor cell masses with round or oval nucleus, with or without vacuoles, and clear cell changes in the rich eosinophilic cytoplasm[ 4 ]. Common LMs are characterized by intertwined spindle cells, cigar-shaped nuclei, eosinophilic cytoplasm, and positivity for smooth-muscle actin or desmin[ 1 ]. The findings of the current case are consistent with the pathological diagnosis of common LMs.…”

“…We searched the PubMed and Geen Medical databases using LLM as a keyword and analyzed the search results (Table 1 ). To our knowledge, including this case, only 12 studies reported relevant patients[ 1 - 3 , 5 - 13 ]. The patients included 11 men and 5 women aged 7-75 years old, and half of the patients were aged 40–70 years (median age, 48 years).…”