Recurrent laryngeal papillomatosis developing into laryngeal carcinoma with human papilloma virus (HPV) type 18: a case report

Sakakura, Atsushi; Yamamoto, Yūzō; Takasaki, Tomohiko; Makimoto, Kazuo; Nakamura, Masahiro; Takahashi, Hiroaki

doi:10.1017/s0022215100132773

Cited by 21 publications

(7 citation statements)

References 16 publications

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“…This procedure is prone to aerosolization of virus and may not be the optimal technique for isolating large quantities of virus. HPVs are potential oncogenic pathogens and genital HPVs have been detected in laryngeal papillomas and carcinomas (Atula et al ., 1999 ; Dickens et al ., 1991 ; Moore et al ., 1999 ; Sakakura et al ., 1996 ). Therefore, we sought to develop an efficient approach for extracting HPV virions that was more biologically contained and that reduced aerosolization of this human pathogen.…”

Section: Resultsmentioning

confidence: 99%

Infectious human papillomavirus type 31b: purification and infection of an immortalized human keratinocyte cell line

Ozbun

2002

Journal of General Virology

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Human papillomaviruses (HPVs) are aetiological agents of human malignancies, most notably cervical cancers. The life-cycles of HPVs are dependent on epithelial differentiation, and this has impeded many basic studies of HPV biology. The organotypic (raft) culture system supports epithelial differentiation such that infectious virions are synthesized in raft tissues from epithelial cells that replicate extrachromosomal HPV genomes. The CIN-612 9E cell line maintains episomal copies of HPV type 31b (HPV31b), an HPV type associated with cervical cancers. Many previous studies, including our own, have focused on characterizing the later stages of the HPV31b lifecycle in CIN-612 9E raft tissues. In this study, we have used the raft system to generate large numbers of HPV31b viral DNA (vDNA)-containing particles. We found a biologically contained homogenization system to be efficient at virion extraction from raft epithelial tissues. We also determined that vDNA-containing particles could be directly quantified from density-gradient fractions. Using an RT-PCR assay, the presence of newly synthesized, spliced HPV31b transcripts was detected following HPV31b infection of the immortalized HaCaT epithelial cell line. Spliced E6 and E1 F E4 RNAs were detected using a single round of RT-PCR from cells infected with a dose as low as 1n0 vDNA-containing particle per cell. Spliced E1*I,E2 transcripts were found in cells infected with an HPV31b dose as low as 10 vDNA-containing particles per cell. Infectivity was blocked by HPV31 antiserum, but was not affected by DNase I. This work lays a foundation for a detailed analysis of the early events in HPV infection.

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Section: Resultsmentioning

confidence: 99%

Infectious human papillomavirus type 31b: purification and infection of an immortalized human keratinocyte cell line

Ozbun

2002

Journal of General Virology

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“…HPV typing was performed in two cases of malignant transformation of adult-onset laryngeal papillomatosis. In these cases, squamous cell carcinomas of the larynx were found to be associated with HPV 6 (18) or HPV 18 (20). Review of the literature shows no reported cases of malignant change of a pulmonary papilloma in the setting of adult-onset papillomatosis.…”

Section: Discussionmentioning

confidence: 98%

Squamous Cell Carcinoma Arising in Recurrent Respiratory Papillomatosis with Pulmonary Involvement: Emerging Common Pattern of Clinical Features and Human Papillomavirus Serotype Association

et al. 2000

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Squamous papillomas of the lung are an uncommon feature of recurrent respiratory papillomatosis, occurring in fewer than 1% of cases. We describe a 23-year-old patient with pulmonary papillomas who developed a fatal squamous cell carcinoma of the lung. PCR-based human papillomavirus (HPV) typing showed the presence of HPV 11 DNA in both benign papillomas and invasive carcinoma. A review of the literature reveals four reports of malignant transformation of juvenile-onset recurrent respiratory papillomatosis in which HPV typing was performed. Similar clinical features are noted in all of the reports; specifically, each case has arisen in a young adult man with a history of papillomatosis since childhood. In each of the cases, HPV 11 was identified in association with the squamous cell carcinoma. Although HPV 11 is uncommonly associated with the development of invasive carcinoma at other sites, these findings suggest that it is correlated with malignant transformation in the setting of juvenile-onset recurrent respiratory papillomatosis. KEY WORDS: Human papillomavirus 11, Recurrent respiratory papillomatosis, Squamous cell carcinoma. Mod Pathol 2000;13(8):914-918Juvenile-onset recurrent respiratory papillomatosis (RRP) is characterized by numerous squamous papillomas of the respiratory tract secondary to infection with human papillomavirus (HPV) types 6 and 11 (1, 2). HPV is thought to be acquired at the time of vaginal delivery in the presence of genital lesions, and patients typically present with symptoms of hoarseness or respiratory obstruction in childhood or adolescence. In the majority of cases, the papillomas are confined to the larynx; only 5% of patients exhibit more distal involvement of the trachea, and involvement of lung parenchyma occurs in fewer than 1% of cases (1, 2). Pulmonary involvement by RRP is twice as frequent in males than in females and is associated with an aggressive clinical course. Most patients require numerous excisions, frequently require tracheostomy, and ultimately die as a result of respiratory insufficiency or infections (2). Malignant transformation of laryngeal or pulmonary lesions is a very rare event in the absence of prior irradiation; fewer than 20 cases are reported in the English literature (3-6). It remains unclear whether the risk of malignant transformation is dependent on the HPV serotype involved.We describe a patient with pulmonary involvement by RRP who developed a squamous cell carcinoma of the lung. Polymerase chain reaction (PCR) typing performed at postmortem examination showed the presence of HPV 11 DNA in both the papillomas and squamous cell carcinoma. This is the fifth report of an association between HPV 11 and malignant transformation of pulmonary papillomas (3, 4, 6, 7). Together, these five cases suggest a stereotypical clinical setting for the emergence of invasive carcinoma from RRP. CASE REPORTThe patient was a 23-year-old white man with a history of RRP, initially diagnosed at age 5. By age 10, he had developed laryngeal, tracheal, and pulmonary ...

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“…Additional reports note that HPV 11 is most frequently followed by malignant transformation, followed by HPV 16/18. [15,16] Furthermore, protein expression of p53, pRb, p21, and p16 in recurrent respiratory papillomatosis has also been reported. Lele studied four cases of juvenile-onset recurrent respiratory papillomatosis progressing to carcinoma in which HPV 11 was the only human papillomavirus type identified in all cases.…”

Section: Discussionmentioning

confidence: 96%

Hypercalcemia with invasive pulmonary papillomatosis and microinvasive squamous carcinoma

Oertling¹,

Daroca²,

Hartz³

et al. 2020

CRCP

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Juvenile respiratory papillomatosis is a rare pediatric disease in which benign papillomata develop in the respiratory tract, most commonly involving the larynx and tracheobronchial tree. Invasive pulmonary papillomatosis is an aggressive form in which the papillomata extend into the lung parenchyma. We report a case of a 22-year-old man with a long-standing juvenile respiratory tract papillomatosis, initially diagnosed at age 2, who subsequently developed invasive pulmonary papillomatosis and underwent partial surgical resection for his pulmonary disease. Hypercalcemia complicated the patient’s final hospitalizations. HPV typing performed on a laryngeal papilloma was positive for HPV 6/11. The lobectomy specimen revealed malignant transformation of invasive pulmonary papillomatosis characterized by the presence of microinvasive nests of squamous carcinoma. Immunohistochemical stain for parathyroid hormone on the invasive component was negative. Eventually, the patient succumbed to his disease and while the family refused post-mortem examination, Positron Emission Tomography (PET) performed during the patient’s terminal course suggested the possibility of metastasis to liver and periaortic lymph nodes. There was no evidence of bony metastasis.

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Recurrent laryngeal papillomatosis developing into laryngeal carcinoma with human papilloma virus (HPV) type 18: a case report

Cited by 21 publications

References 16 publications

Infectious human papillomavirus type 31b: purification and infection of an immortalized human keratinocyte cell line

Infectious human papillomavirus type 31b: purification and infection of an immortalized human keratinocyte cell line

Squamous Cell Carcinoma Arising in Recurrent Respiratory Papillomatosis with Pulmonary Involvement: Emerging Common Pattern of Clinical Features and Human Papillomavirus Serotype Association

Hypercalcemia with invasive pulmonary papillomatosis and microinvasive squamous carcinoma

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