Recurrent leiomyomatosis peritonealis disseminata exacerbated by in vitro fertilization

Deering, Shad; Miller, B S Kathleen A; Kopelman, Jerome; Reed, Mark

doi:10.1067/mob.2000.101978

Cited by 19 publications

(18 citation statements)

References 2 publications

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“…For example, estrogen stimulates the subcelomic mesenchymal cells to proliferate differentiating into myoblasts, myofibroblasts, fibroblasts and even decidua-like cells [6,7] . This hypothesis is supported by cases that are found during pregnancy or after prolonged use of oral contraceptives [8][9][10][11] , after hormone replacement therapy [12] , after tamoxifen use [13] , in patients with estrogen-secreting tumors [1,14,15] or following ovarian stimulation [16][17][18] .…”

Section: Hormonal Theorysupporting

confidence: 52%

Pathophysiology and Possible Iatrogenic Cause of Leiomyomatosis Peritonealis Disseminata

Al-Talib

Tulandi²

2010

Gynecol Obstet Invest

136

123

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We present a case of leiomyomatosis peritonealis disseminata (LPD) after myoma morcellation and review the literature using the keywords leiomyomatosis peritonealis disseminata and disseminated peritoneal leiomyomatosis. The search was conducted in Medline, EMBASE, and Cochrane Database of systematic reviews. We encountered 132 cases of LPD in the English literature; 113 in the reproductive age group, 7 in postmenopausal women, 6 in males, and another in a horse. The possible causes could be divided into hormonal, subperitoneal mesenchymal stem cells, metaplasia, genetic, or iatrogenic after morcellation of myoma during laparoscopic surgery. Our case and 4 others reported in the literature support the contribution of the iatrogenic theory. It appears that LPD could be due to metaplasia of mesenchymal cells of the peritoneum and, in susceptible women, leaving fragments of myoma in the abdominal cavity might contribute to the development of LPD. Accordingly, one should avoid leaving fragments of the uterus or myoma tissue in the abdominal cavity after morcellation.

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Section: Hormonal Theorysupporting

confidence: 52%

Pathophysiology and Possible Iatrogenic Cause of Leiomyomatosis Peritonealis Disseminata

Al-Talib

Tulandi²

2010

Gynecol Obstet Invest

136

123

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“…Leiomyomatosis peritonealis disseminata is usually discovered incidentally during surgery or imaging examinations of women of childbearing age who have uterine leiomyomas. It may be associated with high estrogen states, caused by pregnancy and oral contraceptive use (40), but rare cases in postmenopausal women and men have also been reported (41,42). The majority of pa-tients have a benign clinical course, with spontaneous regression of the leiomyomas or regression following withdrawal of ovarian hormones or oophorectomy.…”

Section: Leiomyomatosis Peritonealis Disseminatamentioning

confidence: 99%

Primary Peritoneal Tumors: Imaging Features with Pathologic Correlation

Levy¹,

Arnáiz²,

Shaw³

et al. 2008

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198

175

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Primary peritoneal tumors are uncommon lesions that arise from the mesothelial or submesothelial layers of the peritoneum. Primary malignant mesothelioma, multicystic mesothelioma, primary peritoneal serous carcinoma, leiomyomatosis peritonealis disseminata, and desmoplastic small round cell tumor are the most prominent of these rare lesions. Primary malignant mesothelioma is a highly aggressive malignancy that occurs most commonly in older men and that has a strong association with high levels of asbestos exposure. It manifests most often as diffuse sheetlike or nodular thickening of the peritoneal surfaces, but it may occasionally be a localized mass. Multicystic mesothelioma occurs most frequently in women and has benign or indolent biologic behavior in the majority of patients. It is a multilocular cystic mass that arises from the pelvic peritoneal surfaces. Primary peritoneal serous carcinoma occurs almost exclusively in women. It is histologically identical to ovarian serous carcinoma and may be indistinguishable from metastatic ovarian carcinoma at imaging studies. Leiomyomatosis peritonealis disseminata is a rare, benign proliferative process that also occurs exclusively in women and is characterized by multiple smooth muscle nodules throughout the peritoneum. Desmoplastic small round cell tumor is a highly aggressive malignancy of unknown origin that occurs most often in the peritoneal cavity of young men. This unusual group of tumors is linked together by a common site of origin and imaging manifestations that mimic those of peritoneal carcinomatosis. Knowledge of the spectrum of imaging findings in this group of primary peritoneal tumors, along with their clinical and pathologic characteristics, is important in the evaluation of patients with diffuse peritoneal disease.

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“…More than half of the reported patients were pregnant or taking oral contraceptives at the time of diagnosis [13]. Also exacerbation of recurrent leiomyomatosis peritonealis disseminata by in vitro fertilisation has been reported [14].…”

Section: Discussionmentioning

confidence: 98%

Two case reports of bowel leiomyomas and review of literature

Pezzuto

Serboli²,

Ceccaroni

et al. 2010

Gynecological Endocrinology

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We report two cases of two women underwent laparoscopic hysterectomy and myomectomy. During surgery, three myomas were identified as completely detached from the uterus, and attached to the bowel. Patients's history revealed a laparoscopic myomectomy. Our first hypothesis therefore was that these were lost myomas of the first surgery. However, only one leyomyoma was removed in both patients. Therefore, we can assume that these myomas were not certainly not lost-myomas and we may conclude that it could be either as residues of previous morcellation or they were pedunculated-myomas that have been spontaneously detached from the uterus and re-implanted onto the bowel.

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Recurrent leiomyomatosis peritonealis disseminata exacerbated by in vitro fertilization

Cited by 19 publications

References 2 publications

Pathophysiology and Possible Iatrogenic Cause of Leiomyomatosis Peritonealis Disseminata

Pathophysiology and Possible Iatrogenic Cause of Leiomyomatosis Peritonealis Disseminata

Primary Peritoneal Tumors: Imaging Features with Pathologic Correlation

Two case reports of bowel leiomyomas and review of literature

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