Recurrent Massive Alveolar Hemorrhage, Crescentic Glomerulonephritis, and Necrotizing Vasculitis in a Patient With Rheumatoid Arthritis

Naschitz, Jochanan E.; Yeshurun, Daniel; Scharf, Y.; Sajrawi, Ibrahim; Lazarov, N; Boss, J. H.

doi:10.1001/archinte.1989.00390020110023

Cited by 20 publications

(3 citation statements)

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“…Necrotizing vasculitis is known as a rare complication that is possibly associated with glomerular crescent. However, in this context, it is to be noted that diffuse proliferative glomerulonephritis with crescent formation is rather unusual in patients with rheumatoid arthritis 21,23 . Koni et al reported three patients with rheumatoid arthritis who developed glomerulonephritis with crescents.…”

Section: Discussionmentioning

confidence: 99%

Glomerular crescents in renal amyloidosis: An epiphenomenon or distinct pathology?

Nagata¹,

Shimokama

Harada

et al. 2001

Pathology International

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There have been several reports of cases of renal amyloidosis with glomerular crescents. However, it is not clear whether the association is fortuitous or pathogenic related. The present study analyzed 105 cases of renal amyloidosis (61 autopsy cases and 44 biopsy cases) and found glomerular crescents in 14 (13.3%) cases. Among the 14 cases with crescents, a female predominance was noted (male: female, 3: 11) and rheumatoid arthritis was the most common primary disease of amyloidosis. Immunohistochemical analysis demonstrated amyloid protein of AA type in 12 cases. According to the histologic classification, there were 11 cases of mesangial nodular type, which was almost exclusively accompanied by AA amyloid deposition. Of note, the incidence of crescents neither correlated with the extent of amyloid deposition nor the presence of nephrotic syndrome. By contrast, localization of amyloid deposition was closely related to crescent formation. Moreover, electron microscopic observation displayed rupture of the glomerular basement membrane at the site of amyloid deposition. Our results indicated that glomerular crescents were more frequently associated with renal amyloidosis than previously appreciated. Rupture of the fragile glomerular basement membrane by amyloid deposition, as revealed by immunostaining and electron microscopy, may be the mechanism of crescent formation. We suggest that glomerular crescents are a distinct pathology associated with renal amyloidosis, not fortuitous conditions.

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Section: Discussionmentioning

confidence: 99%

Glomerular crescents in renal amyloidosis: An epiphenomenon or distinct pathology?

Nagata¹,

Shimokama

Harada

et al. 2001

Pathology International

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“…PHT resembling idiopathic PHT has been associated with RA (90). Alveolar haemorrhage related to pulmonary vasculitis has been reported (91), sometimes with antineutrophil cytoplasmic antibodies (92).…”

Section: Rheumatoid Arthritismentioning

confidence: 99%

The respiratory system in connective tissue disorders

Crestani

2005

Allergy

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The connective tissue disorders (also called collagen vascular diseases) represent an heterogeneous group of immunologically mediated inflammatory disorders with a large variety of affected organs besides the lungs. The respiratory system may be involved in all its components: airways, vessels, parenchyma, pleura, respiratory muscles, etc. The frequency, clinical presentation, prognosis and response to therapy vary, depending on the pattern of involvement as well as on the underlying connective tissue disorders. The subject of this review is to describe the most frequent type of lung disorders observed in patients with connective tissue disease (CTD). We will focus on the most frequent CTD: systemic lupus erythematosus, rheumatoid arthritis, scleroderma, Sjogren's syndrome, dermatopolymyositis and mixed CTD.

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“…Pojedyncze przypadki ZPN opisywano również w przebiegu reumatoidalnego zapalenia stawów (7,19) i mieszanej choroby tkanki łącznej. (9) Opisano także 11 przypadków ZPN w przebiegu twardziny układowej.…”

Section: Występowanie I Przyczynyunclassified

Pulmonary-renal syndrome

Gawryluk

2008

Pneumonol Alergol Pol

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Recurrent Massive Alveolar Hemorrhage, Crescentic Glomerulonephritis, and Necrotizing Vasculitis in a Patient With Rheumatoid Arthritis

Cited by 20 publications

References 20 publications

Glomerular crescents in renal amyloidosis: An epiphenomenon or distinct pathology?

Glomerular crescents in renal amyloidosis: An epiphenomenon or distinct pathology?

The respiratory system in connective tissue disorders

Pulmonary-renal syndrome

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