Recurrent melanotic neuroectodermal tumor of infancy

Shaia, Wayne T.; DiNardo, Laurence J.; Underhill, Thomas E.; Cesca, Christine

doi:10.1053/ajot.2002.123463

Cited by 31 publications

(31 citation statements)

References 18 publications

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“…In case of recurrence, extensive resection associated with reconstructive surgery is indicated. A radical, not too mutilating surgery in young patients is one of the most challenging parts of the treatment (13). The clinical monitoring of the patients and radiological survey are essential.…”

Section: Surgical Managementmentioning

confidence: 99%

Melanotic neuroectodermal tumour of infancy: A case report and review of the aetiopathogenic hypotheses

Madrid

Aziza²,

Hlali³

et al. 2010

Med Oral

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The case of a 2-month-old healthy infant without relevant medical history. The patient was referred due to the aggravation of a swelling occupying the left half of the anterior maxilla. This lesion became visible approximately one month ago; it involved the buccal gingiva and alveolar bone, including the deciduous tooth germs 6.1 and 6.2. The swelling had dimensions of 20 mm x 20 mm. The surgical excision was performed under general anesthesia. The tooth buds of 6.1 and 6.2 were closely related to the tumour and so were removed. The lesion was entirely enucleated. The pathology of the lesion confirmed a melanotic neuroectodermal tumour of infancy. The melanotic neuroectodermal tumour of infancy (MNTI) has been described as a rare benign pigmented painless swelling that usually occurs in the anterior region of the maxilla and in the incisor region. The histological examination showed small basophilic cells, many containing melanin pigmentation within the cytoplasm, with a second population of larger cubical cells with abundant cytoplasm, arranged in alveolar or adenoid clusters. According to Krompecher this tumour derives from epithelial nests evolved at the time of embryonic fusion of the facial processes. It has also been suggested that the tumour arises from the retinal anlage by a pinching-off process of neuroepithelium during the formation of embryonic eye. More recently, the presence of high levels of vanillylmandelic acid suggest a neural origin of the tumour.

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Section: Surgical Managementmentioning

confidence: 99%

Melanotic neuroectodermal tumour of infancy: A case report and review of the aetiopathogenic hypotheses

Madrid

Aziza²,

Hlali³

et al. 2010

Med Oral

View full text Add to dashboard Cite

show abstract

“…Views range from conservative enucleation, to curettage of adjacent tissue, to recommended margins of up to 5 mm (2,18,20,36,37). Efforts should be directed toward the preservation of vital structures and organs (38). Lesion pigmentation and preoperative imaging often assist in delineating tumour margins (14).…”

Section: Discussion and Literature Reviewmentioning

confidence: 99%

“…Adjuvant chemotherapy and radiation are ineffective in controlling recurrences where total excision has not been achieved, and their role is therefore extremely limited (39,40). Authors have advocated their role in metastatic disease and in cases of recurrence after a second resection, although there remains little evidence of added benefit (38,39).…”

Section: Discussion and Literature Reviewmentioning

confidence: 99%

“…Shaia et al (38) examined the risk of recurrence over the past 20 years and found that it did not differ from historical data since the tumour was first diagnosed 90 years previously. More than 80% of recurrences occur in the first four months, (25) with the majority of recurrent tumours occurring in patients initially diagnosed before 12 weeks of age (38). Most patients can achieve cure with repeated surgery (16).…”

Section: Discussion and Literature Reviewmentioning

confidence: 99%

See 1 more Smart Citation

Melanotic neuroectodermal tumour of infancy

Hamilton¹,

MacRae²,

Agrawal³

2008

Plastic Surgery

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Melanotic neuroectodermal tumour of infancy is an extremely rare neoplasm arising in newborns and young children, typically involving the face or cranium. A case arising from the maxilla, requiring extensive resection with a near-total maxillectomy, is presented. A thorough review of the literature on this unusual tumour is provided, with emphasis on prognostic factors and appropriate treatment.Key Words: Maxillectomy; Melanotic; MNTI; Pediatric; Pigmented Tumeur mélanotique neuroectodermique de l'enfance La tumeur mélanotique neuroectodermique de l'enfance, qui touche surtout la face et le crâne, est extrêmement rare chez les nouveau-nés et les jeunes enfants. Il sera question, dans l'article, d'un cas de tumeur du maxillaire, qui a nécessité une résection étendue, voire une maxillectomie quasi totale. Un examen exhaustif de la documentation sur ce type peu fréquent de tumeur, plus particulièrement sur les facteurs pronostiques et le traitement approprié, complétera l'étude du sujet.

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“…However, there are some reports considering the tumor potentially malignant in literature because of the high recurrence rates of 50% and high metastases rates of 5-10% in these studies [6,8]. In a careful review of the literature, it was revealed that 64% of all recurrences appeared in children who were diagnosed at 12 weeks of age or younger and mostly localized in maxilla [9].…”

Section: Discussionmentioning

confidence: 99%