Recurrent Mycobacterium chelonae Skin Infection Unmasked as Factitious Disorder Using Bacterial Whole Genome Sequence Analysis

Flohr, Sarah; Ramette, Alban; Agyeman, Philipp; Duppenthaler, Andrea; Scherer, Cordula; Keller, Peter M.; Aebi, Christoph

doi:10.1093/ofid/ofaa506

Cited by 2 publications

(2 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 2 Although we identified several studies reporting M. chelonae cutaneous and soft‐tissue infections (Table 1 ), these do not definitively confirm M. chelonae as the causative agent, due to either incomplete diagnostic work‐up or not reporting which identification testing was performed. Furthermore, with one exception, 3 each of these reports provided few clinical details, and thus there is limited knowledge of soft‐tissue M. chelonae infections in immunocompetent children.…”

Section: Discussionmentioning

confidence: 99%

Mycobacterium chelonae soft‐tissue infection in an immunocompetent child

Bosman

Beer

Grimwood

2022

J Paediatrics Child Health

View full text Add to dashboard Cite

A previously healthy, fully immunised and immunocompetent 8-year-old child sustained a puncture wound to the dorsum of the left foot from a Bidens pilosa (cobbler's peg) plant while walking through the family's chicken coop. Entry point was in the webspace of toes 2/3. Three-weeks post-injury, erythema and a fluctuant swelling with a purulent discharge developed proximal to toes 2/3. The family doctor prescribed oral cefalexin, but when after a week there was little improvement, an ultrasound demonstrated a foreign body, 14 mm Â 0.5 mm in dimension, between the necks of the second and third metatarsal bones. A referral was then made to our hospital for further management.Four-weeks post-injury, an incision and drainage was undertaken to remove the plant material, and intra-operative samples were sent for culture. No post-operative complications were observed, and the patient was discharged home and advised to

show abstract

Section: Discussionmentioning

confidence: 99%

Mycobacterium chelonae soft‐tissue infection in an immunocompetent child

Bosman

Beer

Grimwood

2022

J Paediatrics Child Health

View full text Add to dashboard Cite

show abstract

“…WGS also allows the identification of NTM at the clone level, thus allowing the form (relapse/reinfection) of the ongoing disease to be determined [33]. Flohr et al have applied WGS in diagnostics of factitious disorders caused by NTM that may be misdiagnosed as a recurrent or chronic forms of infection [34]. The need to correctly clarify the form of the disease is highlighted by the high recurrence rate of some NTM infections, which is up to 10-48% after successful treatment [35,36].…”

Section: Wgs Perspectives For Diagnostics and Characterization Of Resistance Patterns Of Ntmmentioning

confidence: 99%

Whole Genome Sequencing in the Management of Non-Tuberculous Mycobacterial Infections

et al. 2021

View full text Add to dashboard Cite

Infections caused by non-tuberculous mycobacteria (NTM) have been a public health problem in recent decades and contribute significantly to the clinical and economic burden globally. The diagnosis of infections is difficult and time-consuming and, in addition, the conventional diagnostics tests do not have sufficient discrimination power in species identification due to cross-reactions and not fully specific probes. However, technological advances have been made and the whole genome sequencing (WGS) method has been shown to be an essential part of routine diagnostics in clinical mycobacteriology laboratories. The use of this technology has contributed to the characterization of new species of mycobacteria, as well as the identification of gene mutations encoding resistance and virulence factors. Sequencing data also allowed to track global outbreaks of nosocomial NTM infections caused by M. abscessus complex and M. chimaera. To highlight the utility of WGS, we summarize recent scientific studies on WGS as a tool suitable for the management of NTM-induced infections in clinical practice.

show abstract

Recurrent Mycobacterium chelonae Skin Infection Unmasked as Factitious Disorder Using Bacterial Whole Genome Sequence Analysis

Cited by 2 publications

References 15 publications

Mycobacterium chelonae soft‐tissue infection in an immunocompetent child

Mycobacterium chelonae soft‐tissue infection in an immunocompetent child

Whole Genome Sequencing in the Management of Non-Tuberculous Mycobacterial Infections

Contact Info

Product

Resources

About