Recurrent or Residual Hyperparathyroidism and Thyroid Cancer Effectively Evaluated with Scintigraphy

Brenner, M.; Jacene, Heather A.

doi:10.1016/j.otc.2008.05.009

Cited by 7 publications

(4 citation statements)

References 35 publications

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“…Technetium 99m sestamibi (Tc99m-MIBI), particularly when complemented by single emission computed tomography (Tc99m-MIBI-SPECT), is a widely used imaging technique for the preoperative localization of parathyroid adenomas [1,9]. Tc99m-MIBI-SPECT has a sensitivity ranging from 66 to 90% and a positive predictive value ranging from 83 to 100% for pathological parathyroid glands [1,[10][11][12][13][14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

“…Tc99m-MIBI-SPECT has a sensitivity ranging from 66 to 90% and a positive predictive value ranging from 83 to 100% for pathological parathyroid glands [1,[10][11][12][13][14][15][16][17]. However, the test is also known to have lower sensitivity for small adenomas weighing\500 mg [15,18] and in the presence of multiple gland pathology [1,9,15,[17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

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Limitations of Tc99m‐MIBI‐SPECT Imaging Scans in Persistent Primary Hyperparathyroidism

et al. 2010

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BackgroundIn primary hyperparathyroidism (PHPT) the predictive value of technetium 99m sestamibi single emission computed tomography (Tc99m-MIBI-SPECT) for localizing pathological parathyroid glands before a first parathyroidectomy (PTx) is 83–100%. Data are scarce in patients undergoing reoperative parathyroidectomy for persistent hyperparathyroidism. The aim of the present study was to determine the value of Tc99m-MIBI-SPECT in localizing residual hyperactive parathyroid tissue in patients with persistent primary hyperparathyroidism (PHPT) after initial excision of one or more pathological glands.MethodWe retrospectively evaluated the localizing accuracy of Tc99m-MIBI-SPECT scans in 19 consecutive patients with persistent PHPT who had a scan before reoperative parathyroidectomy. We used as controls 23 patients with sporadic PHPT who had a scan before initial surgery.ResultsIn patients with persistent PHPT, Tc99m-MIBI-SPECT accurately localized a pathological parathyroid gland in 33% of cases before reoperative parathyroidectomy, compared to 61% before first PTx for sporadic PHPT. The Tc99m-MIBI-SPECT scan accurately localized intra-thyroidal glands in 2 of 7 cases and a mediastinal gland in 1 of 3 cases either before initial or reoperative parathyroidectomy.ConclusionsOur data suggest that the accuracy of Tc99m-MIBI-SPECT in localizing residual hyperactive glands is significantly lower before reoperative parathyroidectomy for persistent PHPT than before initial surgery for sporadic PHPT. These findings should be taken in consideration in the preoperative workup of patients with persistent primary hyperparathyroidism.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Limitations of Tc99m‐MIBI‐SPECT Imaging Scans in Persistent Primary Hyperparathyroidism

et al. 2010

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“…For adenoma localization, either pre-or postoperatively (in case of recurrence/persistence), localizing studies with [ 99 ] mTc-sestamibi scintigraphy or three-dimensional single-photon emission CT may be used [ 208 ].…”

Section: Phpt Diagnosismentioning

confidence: 99%

The Multiple Endocrine Neoplasia Syndromes

Grozinsky‐Glasberg

Gross

2015

Neuroendocrine Tumours

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The term multiple endocrine neoplasia (MEN) refers to hereditary neoplastic disorder involving more than one endocrine organ and includes the MEN type 1 (MEN1), the MEN type 2 (MEN2), and the familial medullary thyroid carcinoma (FMTC). The estimated frequency of each of these syndromes is around 1 in 30,000 and is characterized by complete penetrance with variable expression [ 1 , 2 ]. The recent progress in our knowledge of both the molecular and the clinical genetics of these syndromes has improved the clinical management of the patients [ 3 ]. On the one hand, the MEN1 gene, a tumor suppressor gene responsible of MEN1 syndrome, is involved in the regulation of several cell functions (e.g., DNA replication and repair and transcriptional machinery). On the other hand, the RET proto-oncogene encodes for a receptor tyrosine kinase protein whose expression is fundamental for appropriate migration, development, and differentiation of neuroendocrine cells originating from neural crest [ 4 ]. Currently, DNA testing allows the early identifi cation of germline mutations in presymptomatic mutant gene carriers in the MEN syndromes [ 5 ]. Consequently, an early identifi cation of the MEN-associated neoplasms and the genotype-phenotype correlation improve the outcome and the quality of life for affected subjects [ 6 ].

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“…For preoperative adenoma localization, three-dimensional singlephoton emission CT may also be used. 29…”

Section: Parathyroid Abnormalitiesmentioning

confidence: 99%

Multiple endocrine neoplasia type 2: An overview

Moline

Eng

2011

Genetics in Medicine

184

143

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Recurrent or Residual Hyperparathyroidism and Thyroid Cancer Effectively Evaluated with Scintigraphy

Cited by 7 publications

References 35 publications

Limitations of Tc99m‐MIBI‐SPECT Imaging Scans in Persistent Primary Hyperparathyroidism

Limitations of Tc99m‐MIBI‐SPECT Imaging Scans in Persistent Primary Hyperparathyroidism

The Multiple Endocrine Neoplasia Syndromes

Multiple endocrine neoplasia type 2: An overview

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