Recurrent or symptomatic residual posterior fossa hemangioblastomas: how are they different from their primary counterparts?

Gupta, Shruti; Pal, Lily; Sardhara, Jayesh; Jaiswal, Awadhesh Kumar; Srivastava, Arun Kumar; Mehrotra, Anant; Das, Kuntal Kanti; Behari, Sanjay

doi:10.1007/s00701-017-3225-x

Cited by 5 publications

(5 citation statements)

References 15 publications

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“…In posterior fossa HBLs with mural nodules, remnant cystic walls from a previous operation may regrow because of diffusion of cerebrospinal fluid. In addition, the presence of multiple satellite lesions that cannot be detected in the operative field can become a cause of recurrence 3) . The HBLs are usually hypervascular, and excessive bleeding may interfere with complete surgical excision.…”

Section: Discussionmentioning

confidence: 99%

Possible Delayed Recurrence of Sporadic Spinal Hemangioblastoma after Complete Surgical Resection: A Case Report

Jung

Kim

Choe

et al. 2021

Nerve

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Spinal cord hemangioblastoma (HBL) is a highly vascularized tumor that occurs sporadically or in relation to von Hippel-Lindau disease. Sporadic-type HBLs in the spinal cord usually present as single lesions that are potentially curable by complete surgical resection, with a low rate of recurrence. We report a case of a totally excised sporadic-type spinal cord HBL with multiple recurrences observed 10 years after surgery. Long-term follow-up may be necessary for spinal cord HBL, even in cases of complete resection.

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Section: Discussionmentioning

confidence: 99%

Possible Delayed Recurrence of Sporadic Spinal Hemangioblastoma after Complete Surgical Resection: A Case Report

Jung

Kim

Choe

et al. 2021

Nerve

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“…Interestingly, sub-analysis regarding extent of surgery (to GTR) did not demonstrate statistical significance. This counters the pervasive, ongoing, clinical notion that extent of resection improves clinical outcome [ 10 ], especially given the high reported rates of recurrence or progression (up to 25-40%) [ 16 ]. The result may be a combination of a few issues.…”

Section: Discussionmentioning

confidence: 99%

“…Similarly, pertinent surgical details are not presented. Utilization of preoperative embolization [ 21 , 22 ], tumor consistency [ 1 , 9 , 16 , 23 ], preoperative status [ 10 ], and postoperative morbidity [ 3 , 24 , 25 ] have been associated with poor outcomes in HBs. Moreover, data regarding disease progression are lacking.…”

Section: Discussionmentioning

confidence: 99%

Intracranial hemangioblastoma - A SEER-based analysis 2004–2013

et al. 2018

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IntroductionIntracranial hemangioblastoma (HB) is a rare pathology. Limited data exist regarding its epidemiology.MethodsWith the SEER-18 registry database, information from all patients diagnosed with intracranial HB from 2004 to 2013 were extracted, including age, gender, race, marital status, presence of surgery, extent of surgery, receipt of radiation, tumor size, tumor location, and follow-up data. Age-adjusted incidence rates and overall survival (OS). Cox proportional hazards model was employed for both univariate and multivariate analyses.ResultsA total of 1307 cases were identified. The overall incidence of intracranial hemangioblastoma is 0.153 per 100,000 person-years [95% confidence interval (CI)=0.145–0.162]. Through univariate analysis, age < 40 [hazard ratio (HR)=0.277, p<0.001], no radiation [HR=0.56, p=0.047], and presence of surgery [HR=0.576, p=0.012] are significant positive prognostic factors. Caucasian race [HR=1.42, p=0.071] and female gender [HR=0.744, p=0.087] exhibit noticeable trends towards positive prognosis. Through multivariate analysis, younger age [HR=1.053, p < 0.01], race [HR=1.916, p<0.01], and presence of surgery [HR=0.463, p<0.01 were significant independent prognostic factors.ConclusionClinical factors such as younger age, Caucasian race, and presence of surgery are significant independent factors for overall survival in patients with HBs. Though analysis regarding extent of surgery did not produce a meaningful relationship, this may be related to surgical bias / expertise. Moreover, no validation for radiation therapy was identified, but this may be related to short follow up intervals and the variable growth patterns of HBs.

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“…They are the most frequent primary intra-axial tumor in adults, occurring in the posterior fossa [ 2 ]. HBMs are varied in appearance, including solid, solid-cystic, or mainly cystic with a small mural, vascularized nidus [ 3 ]. While sporadic HBMs typically present as solitary lesions, their marked vascularity makes them easily mistaken for cerebral arteriovenous malformations (AVMs) or even aneurysms [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

“…2 HBMs are varied in appearance, including solid, solid-cystic, or mainly cystic with a small mural, vascularized nidus. 3 While sporadic HBMs typically present as solitary lesions, their marked vascularity makes them easily mistaken for cerebral arteriovenous malformations (AVMs) or even aneurysms. 4,5 Herein, we present a unique case of a ruptured HBM located in the medulla, which mimicked a craniocervical junction dural arteriovenous fistula (AVF) with an aneurysm.…”

Section: Introductionmentioning

confidence: 99%

Ruptured Medullary Hemangioblastoma Mimicking a Craniocervical Junction Dural Arteriovenous Fistula with a Pseudoaneurysm

Park,

Kwon,

Lee

et al. 2023

Neurointervention

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Hemangioblastomas (HBMs) are rare vascular tumors commonly located in the posterior fossa of adults. A mid-50s patient presented with sudden unconsciousness. Computed tomography scans revealed acute hemorrhages around the posterior fossa, predominantly in the subarachnoid space. Digital subtraction angiography (DSA) revealed an 8-mm round lesion filled with contrast agent, fed by the C1 segmental artery of the left vertebral artery (VA), showing early venous drainage to the spinal cord and brainstem. Emergent embolization was attempted under suspicion of a ruptured dural arteriovenous fistula, resulting in parent artery occlusion due to feeder selection failure. Follow-up DSA after a month depicted a persistent aneurysm via collaterals from both VAs. Consequently, the decision was made to proceed with surgical intervention, leading to the resection of the lesion, confirming its diagnosis as a HBM through histological examination. This case underscores the potential for misdiagnosis when HBMs with an intratumoral shunt mimic vascular shunt lesions.

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Recurrent or symptomatic residual posterior fossa hemangioblastomas: how are they different from their primary counterparts?

Cited by 5 publications

References 15 publications

Possible Delayed Recurrence of Sporadic Spinal Hemangioblastoma after Complete Surgical Resection: A Case Report

Possible Delayed Recurrence of Sporadic Spinal Hemangioblastoma after Complete Surgical Resection: A Case Report

Intracranial hemangioblastoma - A SEER-based analysis 2004–2013

Ruptured Medullary Hemangioblastoma Mimicking a Craniocervical Junction Dural Arteriovenous Fistula with a Pseudoaneurysm

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