Recurrent oral squamous papilloma in a pediatric patient: Case report and review of the literature

Objectives To determine the clinical characteristics of papilloma involving the external auditory canal (PEAC) in a region of China. Study design A retrospective study. Methods Demographics, manifestations, imaging results, histopathology, and treatment of 67 patients diagnosed with PEAC in a period of 6 years were analyzed at Shanghai Eye, Ear, Nose and Throat Hospital in China. Results PEAC were encountered in patients between the ages of 12 and 82 years (mean 53.8 years). It was more prevalent in men (82%) than in women (18%) (P < .05). The clinical presentation was usually a mass in EAC, aural fullness, and hearing loss. Otoscopic and radiological examination were used together for initial diagnosis and pretreatment planning. Unilateral involvement was more common than bilateral involvement (P < .05). The average time between onset of first symptom and surgical resection and/or biopsy was 6.5 months (range, 0.25–60 months). All patients underwent gross total resection. In 5 patients, (7.5%) carcinoma was detected in the specimen. Fifteen patients (22%) had recurrence; recurrent tumors were detected after an average period of 10 months after surgery (range, 4–24 months). Conclusion PEAC is largely a benign lesion with a low risk of malignancy. Optimal management is via gross total resection. However, the risk of recurrence is high, which motivates a need for long‐term monitoring. Level of Evidence 4 Laryngoscope, 131:1132–1137, 2021

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Clinical Characteristics of Patients With Papilloma in the External Auditory Canal

Luo

Peng

et al. 2020

The Laryngoscope

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Oral mucosal calcified nodule requiring palatoplasty

Panico

Robinette

Kelly

et al. 2020

International Journal of Pediatric Otorhinolaryngology

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Overview of Candida albicans and Human Papillomavirus (HPV) Infection Agents and their Biomolecular Mechanisms in Promoting Oral Cancer in Pediatric Patients

Muzio

Ballini

Cantore

et al. 2021

BioMed Research International

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Oral carcinoma represents one of the most common malignancies worldwide. Oral squamous cell carcinomas (OSCCs) account over 90% of all oral malignant tumors and are characterized by high mortality in the advanced stages. Early diagnosis is often a challenge for its ambiguous appearance in early stages. Mucosal infection by the human papillomavirus (HPV) is responsible for a growing number of malignancies, particularly cervical cancer and oropharyngeal carcinomas. In addition, Candida albicans (C. albicans), which is the principal fungi involved in the oral cancer development, may induce carcinogenesis through several mechanisms, mainly promoting inflammation. Medical knowledge and research on adolescent/pediatric patients’ management and prevention are in continuous evolution. Besides, microbiota can play an important role in maintaining oral health and therefore all human health. The aim of this review is to evaluate epidemiological and pathophysiological characteristics of the several biochemical pathways involved during HPV and C. albicans infections in pediatric dentistry.

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Recurrent oral squamous papilloma in a pediatric patient: Case report and review of the literature

Cited by 12 publications

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Clinical Characteristics of Patients With Papilloma in the External Auditory Canal

Clinical Characteristics of Patients With Papilloma in the External Auditory Canal

Oral mucosal calcified nodule requiring palatoplasty

Overview of Candida albicans and Human Papillomavirus (HPV) Infection Agents and their Biomolecular Mechanisms in Promoting Oral Cancer in Pediatric Patients

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