Recurrent pathological fractures in osteitis fibrosa cystica: a case of undetected primary hyperparathyroidism due to parathyroid adenoma

Abeysekera, W. Y. M.; Kumara, P.M.C.; Amarasinghe, Aawk; Fernando, D; Perera, Aravinda

doi:10.4038/sljs.v31i1.5494

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2017

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“…Osteitis fibrosa cystica also known as osteitis fibrosa, osteodystrophia fibrosa, Von Recklinghausen's disease of bone, is a skeletal disorder caused by prolonged exposure of bone to elevated parathyroid hormone levels in primary hyperparathyroidism [3]. Osteitis fibrosa cystica was first reported by von Recklinghausen in 1891; it presents as the end stage findings of hyperparathyroidism.…”

Section: Discussionmentioning

confidence: 99%

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Osteitis Fibrosa Cystica of Tibia as Initial Manifestation of Primary Hyperparathyroidism

Shweta¹,

C²,

M³

et al. 2017

JCR

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Background: Primary hyperparathyroidism is disease of excessive secretion of parathyroid hormone. Osteitis fibrosa cystica or brown tumor, complication of primary hyperthyroidism is characterized by fibrotic cystic bony changes. Skeletal manifestations in the form of brown tumors are rare occuring in less than 2% of patients suffering from any form of hyperparathyroidism. Case Report: We report a 40-year-old woman with lytic lesions in tibia, diagnosed as osteitis fibrosa cystica secondary to parathyroid adenoma. Conclusion: Patients with primary hyperparathyroidism are usually asymptomatic and clinical presentation of the lesion in tibia is rarely a first sign of the disease.

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Section: Discussionmentioning

confidence: 99%

“…The term "Brown tumor" is a misnomer because it is not a true neoplasm, but benign hypervascular focal lesions in bones caused by increased osteoclastic activity and fibroblastic proliferation [4]. They are seen commonly in facial bones, mandible, sternum, pelvis, ribs, femur and rarely in vertebrae [3].…”

Section: Discussionmentioning

confidence: 99%