Recurrent pleural effusion, protein-losing enteropathy, malabsorption, and mosaic warts associated with generalized lymphatic hypoplasia

Abstract

A patient is described who presented with pleural effusions, asymmetrical oedema of the face and limbs, and numerous warts of the hands and feet. He was shown to have vitamin B12 malabsorption, steatorrhoea, and a protein-losing enteropathy. Lymphography showed asymmetrical lymphatic hypoplasia. Jejunal biopsy showed intestinal lymphangiectasia. The hypoproteinaemia responded well to a low-fat, high-protein diet. Corticosteroids at first appeared to speed resolution of the pleural effusion but had only a limited effect. The effusion was attributed to infections injuring a lymphatic system already impaired.

Malignant lymphoma and extensive viral wart formation in a patient with intestinal lymphangiectasia and lymphocyte depletion

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A patient is described, the subject of a previous report (Ross et al, 1971), who subsequently developed gross peripheral mosaic warts and a malignant small bowel lymphoma in association with marked lymphocyte depletion.

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Cutaneous viral infection as a presentation of intestinal lymphangiectasia

“…However, opportunistic infections although increased in incidence are not usually severe, and when they do occur arc bacterial rather than viral in nature (Strober et aL, 1967). One previous patient with IL has been reported to have had extensive warts on his hands and feet (Ross et aL, 1971;Ward et aL, 1977)-We describe two patients with IL, one of whom presented with multiple warts, and the other who presented with severe chickenpox.…”