Recurrent polymorphous haemangioendothelioma

Abstract

A, Fraga J. Dermal infiltrate of enlarged macrophages in patients receiving chemotherapy. J. Cutan. Pathol. 1998; 25; 259-264. 10. Merrill JT, Shen C, Schreibman D et al. Adenosine A receptor promotion of multinucleated giant cell formation by human monocytes: a mechanism for methotrexate-induced nodulosis in rheumatoid arthritis. Arthritis Rheum. 1997; 40; 1308-1315.

Polymorphous hemangioendothelioma in a child with acquired immunodeficiency syndrome (AIDS)

“…The negative immunohistochemical staining for CD34 and HHV‐8 and lack of microabscesses were inconsistent with the suspected diagnosis of Kaposi sarcoma and Bacillary hemangiomatosis. The histopathology was consistent with polymorphous hemangioendothelioma (PH), and the immunohistochemistry was similar to the above reported cases in which immunostaining results are reported 2,4,6.…”

“…Another case report in 2003, presented a woman with previous history of radiation therapy and an intranodal neck lesion 5. A final case report in 2004 presented a 43‐year‐old woman diagnosed in 1997 with a retroperitoneal mass in 1997 and a recurrence in an inguinal node in 2004 6.…”

“…The solid component consists of slightly mitotic polygonal cells with intervening sclerotic stroma. There is evidence of vascular differentiation and angiomatous spaces lined by epithelial cells 1,2,6. The tumor cells typically stain for endothelial, but not epithelial markers 3.…”

“…Polymorphous hemangioendothelioma (PH) is a rare vascular tumor, previously only described in the adult population. We have identified only nine cases reported in six prior publications 1–6. It is described as a rare vascular tumor with borderline malignant potential, so named due to its intermediate behavior between hemangiomata and angiosarcoma 5.…”

“…Histopathologically, it presents with a wide range of microscopic patterns, including solid, primitive vascular, and angiomatous components 6. The solid component consists of slightly mitotic polygonal cells with intervening sclerotic stroma.…”