Recurrent pregnancy loss is associated with increased red cell distribution width and platelet distribution width

Dündar, Özgür; Pektaş, Mine Kanat; Bodur, Serkan; Bakir, Lale; Çetin, Ahmet

doi:10.1111/jog.12600

Cited by 18 publications

(20 citation statements)

References 29 publications

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“…Dundar et al [17] evaluated the components of complete blood count in women with a history of recurrent pregnancy loss and stated that an elevated PDW and red blood cell distribution width values were the associated parameters. In the present study, PDW values between groups did not reach a significant difference (P ¼ 0.438).…”

Section: Discussionmentioning

confidence: 99%

Association between platelet indices and first trimester miscarriage

Akin

Kasap²,

Yuvacı³

et al. 2016

Blood Coagulation &Amp; Fibrinolysis

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We aimed to measure the effect of several potential risk factors on first trimester miscarriage. A total of 169 cases were included in the present study. Patients were selected from women who had first trimester miscarriage (n = 78) and controls were selected from the women who had given birth at term (> 37 weeks of gestation) to healthy infants (n = 91). Compared with the control group, in the miscarriage group gestational age (8.9 ± 2.8 weeks and 8.1 ± 2.2 weeks, respectively, P = 0.032), mean platelet volume (MPV) (8.8 ± 1 and 9.5 ± 1.1 fl, respectively, P < 0.001), plateletcrit (0.209 ± 0.03% and 0.241 ± 0.05%, respectively, P < 0.001), and platelet/lymphocyte ratio (128 ± 37 and 145 ± 60, respectively, P = 0.027) were significantly higher. Multivariate analysis showed that first trimester miscarriage development ratio was 1.909 times higher when MPV value was over 9.1 fl (P < 0.001); 9.147 times higher when plateletcrit value was over 0.219% (P = 0.022). Receiver operating characteristic analysis was performed to determine diagnostic MPV and plateletcrit values for first trimester miscarriage. MPV value greater than 9.1 fl determined miscarriage with 60% sensitivity and 65% specificity, while plateletcrit value greater than 0.219% determined miscarriage with 64.5% sensitivity and 64.7% specificity. MPV and plateletcrit values were strongly associated with first trimester miscarriage. Platelet indices can be used for prediction of fetal loss.

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Section: Discussionmentioning

confidence: 99%

Association between platelet indices and first trimester miscarriage

Akin

Kasap²,

Yuvacı³

et al. 2016

Blood Coagulation &Amp; Fibrinolysis

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“…The kinetics of RDW in women with recurrent pregnancy loss have been evaluated by Dundar et al in 2014 ( 32 ). The authors performed a retrospective analysis of the main blood count indexes in 60 women who had a history of recurrent pregnancy loss, 60 healthy women who had a first trimester pregnancy, and 60 healthy parous women.…”

Section: Discussionmentioning

confidence: 99%

“…The authors found that mean (SD) RDW-CV was significantly higher in women with recurrent pregnancy losses than in pregnant women (16.3% ± 4.6 vs. 14.2% ± 3.1, P = 0.001), and in the 19 women with thrombophilia than in the 41 without (18.4% ± 5.8 vs. 15.3% ± 3.6, P = 0.043). They hypothesized that anisocytosis could increase the thrombotic predisposition of red blood cells; it is not clear whether anisocytosis is the underlying cause, or an epiphenomenon due to pre-existing conditions ( 32 ). …”

Section: Discussionmentioning

confidence: 99%

Red blood cell distribution width in pregnancy: a systematic review

et al. 2018

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Anisocytosis has been associated with the severity and prognosis of several acute and chronic diseases, as well as physiological conditions such as pregnancy. Anisocytosis is quantified by the red blood cell distribution width (RDW), expressed as the ratio, multiplied by 100, between the standard deviation (SD) of red blood cell volumes and the mean corpuscular volume, or as the SD of erythrocyte volumes (RDW-SD). The aim of the present review was to report the state of the art on the physiological values and the putative diagnostic and prognostic roles of RDW in complicated pregnancy. Literature research for articles published in the last ten years was conducted in Pubmed, Web of Science, ClinicalTrials.gov, and Scopus databases. Abstracts were independently screened by two investigators. If relevant, full articles were retrieved. References, in these articles, citing relevant reviews or original studies were also accessed to identify additional eligible studies. Any disagreement between the reviewers was resolved by a third investigator. A total of 28 studies were included in the review. These studies reported changes in RDW values during physiological pregnancy, and associations between the RDW and several pregnancy complications including anaemia, preeclampsia, gestational diabetes, and recurrent miscarriage. This review provides background information for establishing physiological and pathological RDW values in pregnancy for diagnostic and prognostic use in clinical practice.

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“…9 Earlier reports linked MTHFR mutations with increased rates of stillbirth and eclampsia. 10 Current literature findings no longer support hyperhomocysteinemia as an isolated risk factor for VTE, most likely due to increased nutritional availability of folic acid inclusion in nutritional staples such as flour. 8…”

Section: Methylenetetrahydrofolate Reductase Mutationsmentioning

confidence: 96%

Shedding Light on Inherited Thrombophilias

Dobbenga-Rhodes¹

2016

Journal of Perinatal &Amp; Neonatal Nursing

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Physiologic changes of pregnancy result in a hypercoagulable state, placing the risk for venous thromboembolic events at 1 in 1600 births. Venous thromboembolic events are one of the leading causes of maternal mortality. A correlation among venous thromboembolic events, pregnancy complications, and inherited thrombophilia continues to be investigated. This article primarily focuses on the impact of inherited thrombophilias on pregnancy, labor, and birth and yet also addresses acquired thrombophilia. Prophylactic and therapeutic perinatal anticoagulation are lifesaving and pregnancy-sparing interventions. Interprofessional management of these high-risk pregnancies allows for increased surveillance to reduce perinatal morbidity and mortality.

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Recurrent pregnancy loss is associated with increased red cell distribution width and platelet distribution width

Abstract: An elevation in PDW and RDW values was found to be associated with recurrent pregnancy loss.

Cited by 18 publications

References 29 publications

Association between platelet indices and first trimester miscarriage

Association between platelet indices and first trimester miscarriage

Red blood cell distribution width in pregnancy: a systematic review

Shedding Light on Inherited Thrombophilias

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