Recurrent respiratory papillomatosis

Shykhon, M.; Kuo, Michael; Pearman, K.

doi:10.1046/j.1365-2273.2002.00555.x

Cited by 61 publications

(31 citation statements)

References 53 publications

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“…We actually did not find any patient with age over fifteen years in this study. Although some other studies have found the peak presentation of JORRP to be <5 years of age [11]. Our study reported 44.4% of the patients seen as being <5 years of age.…”

Section: Discussioncontrasting

confidence: 56%

Impediments to clinical diagnosis and management of juvenile-onset recurrent respiratory papillomatosis in Ilorin, Nigeria

Adebola¹,

Dunmade²

2013

OJPed

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Section: Discussioncontrasting

confidence: 56%

Impediments to clinical diagnosis and management of juvenile-onset recurrent respiratory papillomatosis in Ilorin, Nigeria

Adebola¹,

Dunmade²

2013

OJPed

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“…This rare benign condition, caused by HPV6 and HPV11, occasionally transforms to frank malignancies. Known risk factors for HPV transmission such as lifetime number of sexual partners and oral-genital sexual contact are also associated with adult recurrent respiratory papillomatosis (10,11). One of the challenges in the hypothesis of HPV as a lung carcinogen lies in establishing the functional consequence of the viral presence in the tumor.…”

Section: Introductionmentioning

confidence: 99%

No Causal Association Identified for Human Papillomavirus Infections in Lung Cancer

Anantharaman¹,

Gheit²,

Waterboer

et al. 2014

Cancer Research

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Human papillomavirus (HPV) infections have been implicated in lung carcinogenesis, but causal associations remain uncertain. We evaluated a potential causal role for HPV infections in lung cancer through an analysis involving serology, tumor DNA, RNA, and p16 protein expression. Association between type-specific HPV antibodies and risk of lung cancer was examined among 3,083 cases and 4,328 controls in two case-control studies (retrospective) and one nested case-control study (prospective design). Three hundred and thirty-four available tumors were subjected to pathologic evaluation and subsequent HPV genotyping following stringent conditions to detect all high-risk and two low-risk HPV types. All HPV DNA-positive tumors were further tested for the expression of p16 protein and type-specific HPV mRNA. On the basis of the consistency of the results, although HPV11 and HPV31 E6 antibodies were associated with lung cancer risk in the retrospective study, no association was observed in the prospective design. Presence of type-specific antibodies correlated poorly with the presence of the corresponding HPV DNA in the tumor. Although nearly 10% of the lung tumors were positive for any HPV DNA (7% for HPV16 DNA), none expressed the viral oncogenes. No association was observed between HPV antibodies or DNA and lung cancer survival. In conclusion, we found no supportive evidence for the hypothesized causal association between HPV infections and lung cancer. Cancer Res; 74(13); 3525-34. Ó2014 AACR.

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“…Such papillomas pose a threat to the patient's health and life, and may undergo oncogenic transformation. Cases of total remission have been reported (33), and papillomas that are due to HPV11 infection are more severe (39).…”

Section: Introductionmentioning

confidence: 99%

Detection of Anti-HPV11-L1 Antibodies in Immune Sera from Patients Suffering from Recurrent Respiratory Papillomatosis Using ELISA

Durzyńska

Błażejewska

Szydłowski³

et al. 2010

Viral Immunology

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CitationDetection of anti-HPV11-L1 antibodies in immune sera from patients suffering from recurrent respiratory papillomatosis using ELISA. Infection with human papillomaviruses (mostly HPV6 and HPV11) may lead to recurrent respiratory papillomatosis (RRP), a chronic disease affecting 2-4/100,000 people. Papillomas have to be removed surgically so patients can breathe normally. Papillomas often grow back and some patients are subjected to a number of operations. In general, asymptomatic HPV-positive people have low levels of antiviral antibodies in their sera, as the human humoral response is weak due to HPV's biology. In patients suffering from RRP who have undergone multiple surgeries, a blood-epithelium barrier breach stimulates the production of anti-HPV antibodies. Our study's aim was to produce HisTag-HPV11-L1 major capsid protein in E. coli cells, and to purify it. We also sought to detect anti-HPV11-L1 antibodies in antisera obtained from RRP patients using ELISA. Clinical samples were collected from 47 patients with RRP (antisera and papillomas), and from 32 controls (sera and oral swabs), from the Wielkopolska region of Poland. Antisera and control sera were used to coat microplates, HisTag-HPV11-L1 antigen was applied, and antibody-antigen complexes were detected by anti-HisTag monoclonal antibody in an ELISA assay. Simultaneously, total cellular DNA was extracted from papillomas and oral squamous cells obtained from controls. All DNA samples were screened for HPV DNA using MY-PCR. All patients were HPV-positive (30% for HPV6 and 70% for HPV11). Statistically significant correlations were found between the amount of anti-HPV11-L1 antibodies in the sera of RRP patients and the number of surgical procedures they underwent. Although HPV virus-like particles are most often used for anti-HPV antibody detection, the ELISA method presented herein is another viable option for use in RRP patients.

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Recurrent respiratory papillomatosis

Cited by 61 publications

References 53 publications

Impediments to clinical diagnosis and management of juvenile-onset recurrent respiratory papillomatosis in Ilorin, Nigeria

Impediments to clinical diagnosis and management of juvenile-onset recurrent respiratory papillomatosis in Ilorin, Nigeria

No Causal Association Identified for Human Papillomavirus Infections in Lung Cancer

Detection of Anti-HPV11-L1 Antibodies in Immune Sera from Patients Suffering from Recurrent Respiratory Papillomatosis Using ELISA

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