Recurrent Respiratory Papillomatosis: A Longitudinal Study Comparing Severity Associated With Human Papilloma Viral Types 6 and 11 and Other Risk Factors in a Large Pediatric Population

Wiatrak, Brian J.; Wiatrak, Deborah W.; Broker, Thomas R.; Lewis, Linda S.

doi:10.1097/01.mlg.000148224.83491.0f

Cited by 256 publications

(228 citation statements)

References 102 publications

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“…Conversely, late (adult) onset RRP may be more likely than juvenile RRP to retain features of the productive HPV phenotype, which may also contribute to adult lesion recurrence. Previous studies have shown HPV 11 to be associated with a more aggressive clinical course in children, including development of tracheal disease, pulmonary disease, and greater frequency of surgical procedures including tracheotomies [20][21][22]. However, HPV 11 was not demonstrated to be a significant biomarker of recurrence or dysplasia in juveniles in this study: only 28.6% of juveniles with recurrent papillomas, and only 40% of those with C1 dysplastic papilloma were positive for HPV 11.…”

Section: Discussioncontrasting

confidence: 77%

In Situ Hybridization Signal Patterns in Recurrent Laryngeal Squamous Papillomas Indicate that HPV Integration Occurs at an Early Stage

Brooks

Evans

Adamson

et al. 2011

Head and Neck Pathol

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Laryngeal papillomas are benign tumors that frequently recur and can compromise airways. We investigated HPV genotype, physical status, and protein expression in juveniles versus adults. Thirty-five laryngeal papilloma specimens were obtained from ten juveniles (1-16 years) and eleven adults (24-67 years). In cases of recurrent papillomatosis (7 juveniles, 7 adults), the first and last papillomas were assayed. HPV type was determined by GP5?/6? PCR and dot blot hybridization. In situ hybridization (ISH) was performed on 34 specimens; the data were recorded in terms of diffuse (episomal HPV) and punctate (integrated HPV) signal patterns. Immunohistochemistry for the HPV L1 capsid protein, a marker of HPV productive status, was performed on 32 samples. All samples tested HPV positive: HPV 11 in 2/10 (20.0%) juveniles and 5/11 (45.5%) adults; HPV 6 in 7/10 (70%) juveniles and 5/11 (45.5%) adults; and HPV 6/11 double infection was noted in one juvenile and one adult. ISH signals (punctate ± diffuse) were detected among 7/10 (70.0%) juveniles and 7/11 (63.6%) adults. L1 staining was detected in 1/9 (11.1%) juveniles and 6/10 (60.0%) adults (P = 0.06). These data support the idea that integration of low-risk HPV types into the cell genome is an early and common event in the etiology of juvenile and adult recurrent laryngeal papillomas. Productive HPV infections may be more common in adults; accordingly, constant laryngeal re-infection by HPV shed from a productive lesion may contribute to adult recurrent lesions, whereas the mechanism of papilloma recurrence in juveniles may be more attributable to HPV integration.

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Section: Discussioncontrasting

confidence: 77%

In Situ Hybridization Signal Patterns in Recurrent Laryngeal Squamous Papillomas Indicate that HPV Integration Occurs at an Early Stage

Brooks

Evans

Adamson

et al. 2011

Head and Neck Pathol

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“…Such papillomas pose a threat to the patient's health and life, and may undergo oncogenic transformation. Cases of total remission have been reported (33), and papillomas that are due to HPV11 infection are more severe (39).…”

Section: Introductionmentioning

confidence: 99%

Detection of Anti-HPV11-L1 Antibodies in Immune Sera from Patients Suffering from Recurrent Respiratory Papillomatosis Using ELISA

Durzyńska

Błażejewska

Szydłowski³

et al. 2010

Viral Immunology

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CitationDetection of anti-HPV11-L1 antibodies in immune sera from patients suffering from recurrent respiratory papillomatosis using ELISA. Infection with human papillomaviruses (mostly HPV6 and HPV11) may lead to recurrent respiratory papillomatosis (RRP), a chronic disease affecting 2-4/100,000 people. Papillomas have to be removed surgically so patients can breathe normally. Papillomas often grow back and some patients are subjected to a number of operations. In general, asymptomatic HPV-positive people have low levels of antiviral antibodies in their sera, as the human humoral response is weak due to HPV's biology. In patients suffering from RRP who have undergone multiple surgeries, a blood-epithelium barrier breach stimulates the production of anti-HPV antibodies. Our study's aim was to produce HisTag-HPV11-L1 major capsid protein in E. coli cells, and to purify it. We also sought to detect anti-HPV11-L1 antibodies in antisera obtained from RRP patients using ELISA. Clinical samples were collected from 47 patients with RRP (antisera and papillomas), and from 32 controls (sera and oral swabs), from the Wielkopolska region of Poland. Antisera and control sera were used to coat microplates, HisTag-HPV11-L1 antigen was applied, and antibody-antigen complexes were detected by anti-HisTag monoclonal antibody in an ELISA assay. Simultaneously, total cellular DNA was extracted from papillomas and oral squamous cells obtained from controls. All DNA samples were screened for HPV DNA using MY-PCR. All patients were HPV-positive (30% for HPV6 and 70% for HPV11). Statistically significant correlations were found between the amount of anti-HPV11-L1 antibodies in the sera of RRP patients and the number of surgical procedures they underwent. Although HPV virus-like particles are most often used for anti-HPV antibody detection, the ELISA method presented herein is another viable option for use in RRP patients.

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“…6,7 Anogenital warts are also caused by low-risk HPV types 6 and 11. High-risk HPV types cause precancers and cancer of the penis and anus.…”

mentioning

confidence: 99%

“…5 The low-risk types of HPV cause recurrent respiratory papillomatosis or condylomata of the nasopharynx. 6,7 Anogenital warts are also caused by low-risk HPV types 6 and 11. High-risk HPV types cause precancers and cancer of the penis and anus.…”

mentioning

confidence: 99%

Variables Associated With Human Papillomavirus (HPV) Vaccine Acceptance by Men

Ferris

Waller²,

Miller

et al. 2009

The Journal of the American Board of Family Medicine

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Objective: To determine correlates of human papillomavirus (HPV) vaccine acceptance for men.Methods: A convenience sample of men aged 18 to 45 years read a one-page information sheet about HPV and the HPV vaccine, then completed a 29-item questionnaire.2 tests were used to determine whether differences in demographic, sexual, and vaccine-related variables existed between levels of wanting the HPV vaccine.Results: Positive correlates of HPV vaccine acceptance included higher education (P < .0001); hispanic ethnicity (P ‫؍‬ .0003); wearing a seat belt most of the time (P ‫؍‬ .02); regular tobacco use (P ‫؍‬ <.001); not being sexually active (P ‫؍‬ .0008); history of more than 10 female sexual partners (P ‫؍‬ .0004); not having oral sex (P ‫؍‬ .045); extreme worry about vaccine side effects (P < .0001); extreme concern about vaccine safety (P < .0001); the importance of getting vaccines (P < .0001); familiarity with HPV (P < .0001); and extreme importance of receiving the HPV vaccine (P < .0001).Conclusions In 2006, the US Food and Drug Administration (FDA) approved the quadrivalent human papillomavirus (HPV, types 6/11/16 and 18) L1 virus-like particle vaccine. This prophylactic vaccine prevents cervical, vaginal, vulvar, and perianal neoplasias, including anogenital condylomata.1-4 Based on epidemiologic data, the vaccine should reduce the incidence of cervical cancer by 70% and genital warts by 90%. Universal protection is afforded when administered to people not previously exposed to the HPV types covered by the vaccine. Currently, the vaccine is approved for use in 9-to 26-year-old girls and women.Many low-risk and high-risk types of HPV can also infect various anatomic sites in boys and men. 5The low-risk types of HPV cause recurrent respiratory papillomatosis or condylomata of the nasopharynx. 6,7 Anogenital warts are also caused by low-risk HPV types 6 and 11. High-risk HPV types cause precancers and cancer of the penis and anus.8 -13 HPV 16, a particularly virulent type, causes head and neck cancer.14,15 Just as with women, men experience significant morbidity and potential mortality from HPV-related diseases.Women clearly benefit from receiving the HPV vaccine. One would assume men could also benefit by being vaccinated against low-and high-risk HPV types. Correlates of HPV vaccine acceptance have been identified for mid-adult women.16 However, correlates of HPV vaccine acceptance among men have not been described. The purpose of these analyses were to determine correlates of HPV vaccine acceptance among men. Methods PopulationA convenience sample of 18-to 45-year-old men were recruited to participate in our study. Subjects were enrolled at various places in Augusta and Atlanta, Georgia, including a local military base, college campuses, fire stations, a university-based family medicine center waiting room, and from elsewhere in the community. Inclusion criteria included an interest to complete a brief questionnaire; being a man; 18-to 45-years-old; and an This article was externally peer reviewed.

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Recurrent Respiratory Papillomatosis: A Longitudinal Study Comparing Severity Associated With Human Papilloma Viral Types 6 and 11 and Other Risk Factors in a Large Pediatric Population

Cited by 256 publications

References 102 publications

In Situ Hybridization Signal Patterns in Recurrent Laryngeal Squamous Papillomas Indicate that HPV Integration Occurs at an Early Stage

In Situ Hybridization Signal Patterns in Recurrent Laryngeal Squamous Papillomas Indicate that HPV Integration Occurs at an Early Stage

Detection of Anti-HPV11-L1 Antibodies in Immune Sera from Patients Suffering from Recurrent Respiratory Papillomatosis Using ELISA

Variables Associated With Human Papillomavirus (HPV) Vaccine Acceptance by Men

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