Recurrent respiratory papillomatosis with malignant transformation

Marchiori, Edson; Zanetti, Gláucia; Barreto, Míriam Menna; Rodrigues, Rosana Souza

doi:10.1111/j.1440-1843.2010.01763.x

Cited by 5 publications

(6 citation statements)

References 5 publications

(16 reference statements)

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“…Tracheobronchial papillomatosis rarely affects the pulmonary parenchyma. When it does, tomographic findings include cystic lucencies and pulmonary nodules, as well as papillomas in the airway [105][106][107].…”

Section: Other Multiple Cystic Lung Diseasesmentioning

confidence: 99%

Multiple cystic lung disease

et al. 2015

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Multiple cystic lung disease represents a diverse group of uncommon disorders that can present a diagnostic challenge due to the increasing number of diseases associated with this presentation. High-resolution computed tomography of the chest helps to define the morphological aspects and distribution of lung cysts, as well as associated findings. The combination of appearance upon imaging and clinical features, together with extrapulmonary manifestations, when present, permits confident and accurate diagnosis of the majority of these diseases without recourse to open-lung biopsy. The main diseases in this group that are discussed in this review are lymphangioleiomyomatosis, pulmonary Langerhans cell histiocytosis and folliculin gene-associated syndrome (Birt-Hogg-Dubé); other rare causes of cystic lung disease, including cystic metastasis of sarcoma, are also discussed. Disease progression is unpredictable, and understanding of the complications of cystic lung disease and their appearance during evolution of the disease are essential for management. Correlation of disease evolution and clinical context with chest imaging findings provides important clues for defining the underlying nature of cystic lung disease, and guides diagnostic evaluation and management.

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Section: Other Multiple Cystic Lung Diseasesmentioning

confidence: 99%

Multiple cystic lung disease

et al. 2015

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“…RRP manifest as mucosal, exophytic and benign neoplasms, usually consisting of irregular, multiple and cauliflower-like clusters, which have an intact basement membrane [11,19]. The patients with RRP experience a different course of the disease.…”

Section: Introductionmentioning

confidence: 99%

“…It is known that human papilloma virus type 11-positive patients show a more frequent incidence of malignisation. The majority of the malignant lesions are laryngeal squamous cell carcinomas (LSCC) [3,11].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the chicken embryo chorioallantoic membrane model for laryngeal tumor transplantation

Kuzminienė

Šalomskaitė-Davalgienė

Balnytė

et al. 2012

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The laryngeal squamous cell carcinoma is the second common malignant tumor of the respiratory tract and together with recurrent respiratory papillomas represents the most common tumors of the larynx. Many experimental models are used to study the morphology of malignant tumors. The chicken chorioallantoic membrane (CAM) model is one of them. The CAM has all the nutrition needed for the piece of the transplanted tumor to survive. The aim of this study was to investigate whether the laryngeal papilloma and the laryngeal squamous cell carcinoma tissues transplanted on the chick CAM survive with their main histological features, and to determine the morphological changes of the CAM with different transplants. For the preparation of the CAM, fertilized hen eggs were put into an incubator for 3 days. Then the windows in the shell were opened. The fresh samples of tumors were transplanted on the CAM on the 7 th day of incubation. After 3 days after transplantation the CAM with onplants were excised and fixed in the 10% formalin solution. Morphological changes in the control CAM and in the CAM with tumor onplants were observed using the digital camera on the OLYMPUS microscope. The results showed that the CAM with the laryngeal squamous cell carcinoma onplant was distinctly thicker than that of the control group and than the CAM with the papilloma onplant; the chorionic epithelium was thickened and appeared stratified of up to 5-6 layers and in some locations squamous keratinized; the mesenchymal cells were densely arranged under the tumor transplants. We observed that morphological changes in the thickness of the CAM and the chorionic epithelium were more obvious in the CAM under the 230 A. Kuzminienė et. al. carcinoma transplants. After 72 hours of the tumor tissue transfer onto the membrane, the tumor cells retained their vitality and also their influence on the CAM tissues could be observed.

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“…1 The authors also reported that the initiating factors for rapid growth of papillomas are not known but that a mechanism involving post-obstructive pneumatoceles may play a role in cyst formation.…”

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confidence: 99%

“…Marchiori et al 1 . reported a case of recurrent respiratory papillomatosis (RRP) with malignant transformation, and stated that the abnormal growth of lesions and the detection of human papillomavirus (HPV) type 11 are important findings that suggest malignant transformation in RRP.…”

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confidence: 99%