Recurrent Solitary Fibrous Tumor of the Falx Cerebri With Intraventricular Extension-Case Report-

Teranishi, Kohsuke; Yamamoto, Takuji; Nakao, Yasuaki; Osada, Hideo; Wada, Ryo; Mori, Kentaro

doi:10.2176/nmc.47.269

Cited by 14 publications

(7 citation statements)

References 14 publications

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“…Six of these tumors were located in the fourth ventricle [2-7], eight cases were in lateral ventricle location [1,9-14], one tumor located in the third ventricle [15], one case occurred in the foramina of Monro [16] and one case was a recurrent SFT arising from the falx cerebri, extending to the bilateral lateral ventricles and the third ventricle [17]. The clinical and radiological features of these tumors are given in Table 1; the immunomorphological features are given in Table 2.…”

Section: Discussionmentioning

confidence: 99%

Fourth ventricular solitary fibrous tumor: a case report and review of the literature

et al. 2012

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Introduction Solitary fibrous tumors of the central nervous system usually present as dura-based masses and clinically resemble meningiomas. There are very few reported cases of intra-ventricular solitary fibrous tumors, particularly in the fourth ventricle. Case presentation Our patient was a 52-year-old African-American man, who presented to our facility with a two-month history of progressive weakness and numbness in all extremities. A computed tomography scan and brain magnetic resonance imaging scan revealed a homogeneous, avidly enhancing 4.5 × 3.7 × 2.7cm fourth ventricular mass, with compression of adjacent medulla and cerebellum and extension into the foramen of Luschka. Our patient underwent a suboccipital craniotomy and resection of the tumor. A histological examination showed a spindle cell neoplasm with prominent collagenized stroma. The neoplastic cells were strongly and diffusely positive for CD34, vimentin and Bcl-2, and negative for S-100, CD99 and epithelial membrane antigen. The molecular immunology Borstel-1 (MIB-1) proliferation index was low (1%). CD31 immunostain highlighted the endothelial cells but the spindle cells were negative. Reticulin stain demonstrated a moderate reticulin network but individual cells were not invested by reticulin fibers. The histological features and immunoprofile was consistent with a solitary fibrous tumor. Conclusions In the central nervous system, solitary fibrous tumors are usually indolent tumors, with only rare examples showing hypercellularity and increased mitotic activity; features that were absent in our patient’s case. We present an uncommon central nervous system neoplasm in a rare location. Although uncommon, solitary fibrous tumors should be included in the differential diagnosis of intra-ventricular tumors in adults.

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Section: Discussionmentioning

confidence: 99%

Fourth ventricular solitary fibrous tumor: a case report and review of the literature

et al. 2012

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“…Ultrastructural examination has been applied to the study of SFT of the CNS, 64,66,68,70,71,73,78,81,83,85,86,91,105,116,127,130,140,149 with the purpose to establish a diagnosis and/or to investigate the lineage of the constituent tumor cell. The SFT cells show prototypical features of mesenchymal cells with oval to spindle-shaped nuclei, well-developed rough endoplasmic reticulum, cytoplasmic organelles such as the Golgi apparatus and mitochondria, occasional collections of actin-like microfilaments at the cell periphery, absent intercellular interdigitations, external basal lamina, and specialized intercellular junctions, all concordant with fibroblastic differentiation (Fig.…”

Section: Other Morphological Studiesmentioning

confidence: 99%

Solitary Fibrous Tumor of the Central Nervous System

Bisceglia

Galliani

Giannatempo³

et al. 2011

Advances in Anatomic Pathology

100

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We reviewed the world literature on solitary fibrous tumors of the central nervous system from August 1996 to July 2011, focusing on both clinicopathological features and diagnostic findings. The anatomical distribution of the 220 cases reported so far reveals that most are intracranial and just over one-fifth are intraspinal. In decreasing frequency, intracranial tumors involve the supratentorial and infratentorial compartments, the pontocerebellar angle, the sellar and parasellar regions, and the cranial nerves. Intraspinal tumors are mainly located in the thoracic and cervical segments. Although most solitary fibrous tumors of the central nervous system are dural based, a small subset presents as subpial, intraparenchymal, intraventricular, or as tumors involving the nerve rootlets with no dural connection. Preoperative imaging and intraoperative findings suggest meningioma, schwannoma or neurofibroma, hemangiopericytoma, or pituitary tumors. Immunohistochemistry is critical to establish a definitive histopathological diagnosis. Vimentin, CD34, BCL2, and CD99 are the most consistently positive markers. The usual histologic type generally behaves in a benign manner if complete removal is achieved. Recurrence is anticipated when resection is subtotal or when the tumor exhibits atypical histology. The proliferative index as assessed by MIB1 labeling is of prognostic significance. Occasionally, tumors featuring conventional morphology may recur, perhaps because of minimal residual disease left behind during surgical extirpation. Rare extracranial metastases and tumor-related deaths are on record. Surgery is the treatment of choice. Stereotactic and external beam radiation therapy may be indicated for postsurgical tumor remnants and for unresectable recurrences. Long-term active surveillance of the patients is mandatory.

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“…The usual sites are clinoid process (1), orbit, sellar-and parasellar area (10), middle cranial fossa (1), cerebellopontine angle (2,17), lateral ventricle (18) and the falx cerebri (8,20). In the lateral ventricle the favoured sites are the body and trigone.…”

Section: Discussionmentioning

confidence: 99%

“…The chemotherapeutic agent Toremifene can also be administered if the proliferation rate is high (10). Recurrence and also malignant transformation have been reported in meningeal solitary fibrous tumors (6,11,16,20,21). Hakan et al, in their review, have come across a higher rate of recurrence in tentorial tumors that they have attributed to the incompleteness of resection (5).…”

Section: Discussionmentioning

confidence: 99%

Solitary fibrous tumor of the tentorium – a case report

Alapatt

Ajaya²,

Govindan³

et al. 2010

Turkish Neurosurgery

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The authors describe the clinical and pathological features of a solitary fibrous tumor of the tentorium, a rare location for the tumor in the CNS. A 52-year-old lady presented to the neurosurgical services with headache of four months and vertigo of one and a half months duration. On examination, she had left-sided cerebellar signs and bilateral papilloedema. Cranial MR imaging showed an enhancing tumor based on the left tentorium. Clinical impression was a meningioma. The patient underwent left suboccipital craniectomy. The tumor was firm and vascular, extending above the tent through a defect. Total excision was achieved. The correct diagnosis of solitary fibrous tumor could be made only by histopathology. Solitary fibrous tumors of the tentorium, though rare, should be included in the differential diagnosis of dural based masses.KeywoRds: Solitary fibrous tumor, Tentorium, Meningioma, CD 34, Hemangiopericytoma, Vimentin ÖZ Yazarlar MSS'de tümör için nadir bir konum olan tentoriuumda soliter fibröz tümörün klinik ve patolojik özelliklerini tanımlamaktadır. 52 yaşında bir kadın hasta beyin cerrahisi polikliniğine dört aydır başağrısı ve bir buçuk aydır başdönmesiyle başvurdu. Muayenede sol tarafta serebellar bulgular ve bilateral papilla ödemi mevcuttu. Kraniyal MR görüntüleme sol tentorium temelli kontrast tutan bir tümör gösterdi. Klinik izlenim menenjiyomdu. Hastaya suboksipital kraniyektomi yapıldı. Tümör sert ve vaskülerdi ve bir defekt yoluyla çadırın üzerine uzanmaktaydı. Total eksizyon yapıldı. Soliter fibröz tümörün doğru tanısı sadece histopatoloji ile konabildi. Tentorium soliter fibröz tümörleri nadir olmalarına rağmen dura kökenli kitlelerin ayırıcı tanısında dikkate alınmalıdır.ANAHTAR sÖZCÜKLeR: Soliter fibröz tümör, Tentorium, Menenjiyom, CD 34, Hemanjiyoperisitom, Vimentin

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Recurrent Solitary Fibrous Tumor of the Falx Cerebri With Intraventricular Extension-Case Report-

Cited by 14 publications

References 14 publications

Fourth ventricular solitary fibrous tumor: a case report and review of the literature

Fourth ventricular solitary fibrous tumor: a case report and review of the literature

Solitary Fibrous Tumor of the Central Nervous System

Solitary fibrous tumor of the tentorium – a case report

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