Recurrent staphylococcal infections and chronic dermatitis in a 45-year-old man

Vera, Michelle De; Yu, Byung-Ho

doi:10.1016/s1081-1206(10)63525-9

Cited by 1 publication

(1 citation statement)

References 61 publications

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“…Interestingly, immunodeficiency symptoms may not be manifested until much later, and many cases of diagnosis after 65 years of age are described, including a case with the primary diagnosis made in a 88-year-old patient (Hawkins et al 2003). Because most physicians are unaware of this condition it is often misdiagnosed, frequently confused with AIDS (Kaczmarski et al 1994), severe asthma or autoimmune diseases (Fontan Casariego 2001, Rusconi et al 2003, Kart et al 2003, Heeney et al 2003, De Vera and Yu 2003, Byrne et al 2003. CVID has no gender preference, although women tend to manifest the disease later in life, after the diagnosis the survival rate is similar for both sexes ( of the patients are Caucasians (50-70%), some are mixed race (20-19.8%) and one patient is AfricanAmerican (1.5%).…”

Section: Clinical Characteristics Of the Patients With Cvidmentioning

confidence: 99%

Clinical and laboratory aspects of common variable immunodeficiency

Kokron

Errante

Barros

et al. 2004

An. Acad. Bras. Ciênc.

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Common variable immunodeficiency (CVID) is an immunological disorder characterized by defective antibody production, recurrent infections, most notably of the respiratory tract, autoimmune phenomena and cancer. Some CVID patients may also present disturbances of the cellular immune response such as a decrease in the number and proportion of different lymphocyte populations, diminished lymphoproliferative response to mitogens and antigens, altered production of cytokines, and deficient expression of cell-surface molecules. Most Brazilian CVID patients included in this study show a decrease in T and B lymphocyte counts in the peripheral blood. Furthermore, their lymphocytes are more susceptible to apoptosis following activation than normal individuals, and they have a decrease in the expression of activation molecules like CD25, CD69, CD40L and CD70. Moreover, they show a decreased synthesis of IL-4 and IL-5 in comparison with normal individuals. The increase in susceptibility to apoptosis following activation, may also be responsible for the decrease in the expression of activation molecules and CD40L, decrease in Th2 cytokines synthesis, and in the number of T and B circulating cells. In this study we discuss some of these immunological disturbances correlating them to the patients' clinical features and comparing our patients' findings to the literature.

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