Recurrent stress across life may improve cognitive performance in individual rats, suggesting the induction of resilience

Hadar, Ravit; Edemann-Callesen, Henriette; Hlusicka, Elizabeth Barroeta; Wieske, Franziska; Vögel, Martin; Günther, Lydia; Vollmayr, Barbara; Hellweg, Rainer; Heinz, Andreas; Garthe, Alexander; Winter, Christine

doi:10.1038/s41398-019-0523-5

Cited by 10 publications

(4 citation statements)

References 45 publications

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“…One potential explanation is that more significant life disruptions with diagnosis increased motivation and effort for attentional control as an adaptive coping mechanism; studies such as Fields et al (2021) mentioned that exposure to early caregiving instability can lead to both decrements and enhancements in cognitive control, with potential for adaptation. Also, Moser et al (2012) showed that trait anxiety is associated with increased attentional distraction, suggesting a general enhancement of bottom-up processes involved in motivational significance detection; Hadar et al (2019) mentioned that Recurrent stress may also have a beneficial effect on cognitive performance in some individuals, potentially inducing resilience.…”

Section: Discussionmentioning

confidence: 99%

Associations between Recurrent COVID-19, Attention, and Mental Health: A Longitudinal Study

Khodami,

Hosseini,

Bagheri

et al. 2024

Preprint

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This two-part longitudinal study examined the impacts of initial and recurrent COVID-19 diagnosis on negative affect (Depression, Anxiety, and Stress) and attention control in undergraduate students during pandemic lockdowns. Study 1 found that first-time diagnosis was associated with significantly higher depression, anxiety, and stress but did not affect attention control. Study 2 showed recurrent diagnosis further worsened mental health outcomes yet was linked to enhanced attentional abilities, contrasting typical condition declines. Within-subjects analysis demonstrated a worsening effect but improved attention control from first to second-time points among repeatedly diagnosed participants. Overall, both initial and recurrent diagnoses severely impact psychological well-being with cumulative mental health tolls, underscoring the need to prioritize supporting mental health. However, attentional resilience emerges, potentially reflecting an adaptive coping response. Continued research tracking patients across multiple infections can clarify relationships between worsening emotions and improved attention, informing interventions to address the multifaceted health impacts of COVID-19 reinfection.

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Section: Discussionmentioning

confidence: 99%

Associations between Recurrent COVID-19, Attention, and Mental Health: A Longitudinal Study

Khodami,

Hosseini,

Bagheri

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…As a confirmatory test, these miRNAs, when injected in vitro into the zygote, showed a decreased cortisol level (41). There are other studies stating that experiences and stresses in life improve cognitive function and provide resilience (43); however, the exact mechanism of transgenerational/intergenerational inheritance remains unknown. Several early stressors and experiences in life have been shown to improve tolerability in the future.…”

Section: Sperm Sncrnas In Transgenerational Inheritancementioning

confidence: 93%

Small RNAs: an ideal choice as sperm quality biomarkers

Mehta,

Singh

2024

Front. Reprod. Health

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Spermatozoa were classically known as vehicles for the delivery of the paternal genome to the oocyte. However, in 1962, spermatozoa were discovered to carry significant amounts of RNA in them, which raised questions about the significance of these molecules in such a highly specialized cell. Scientific research in the last six decades has investigated the biological significance of sperm RNAs by various means. Irrespective of what sperm RNAs do, their presence in spermatozoa has attracted attention for their exploitation as biomarkers of fertility. Research in this direction started in the year 2000 and is still underway. A major hurdle in this research is the definition of the standard human sperm RNAome. Only a few normozoospermic samples have been analyzed to define the normal sperm RNAome. In this article, we provide a perspective on the suitability of sperm RNAs as biomarkers of fertility and the importance of defining the normal sperm RNAome before we can succeed in identifying RNA-based biomarkers of sperm quality and fertility. The identification of sperm RNA biomarkers of fertility can be exploited for quality screening of donor sperm samples, explain infertility in idiopathic cases, and RNA therapeutics for the treatment of male infertility.

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“…However, it is known that memory retention is enhanced after stress ( Roozendaal and McGaugh, 1996 ; Barsegyan et al, 2010 ), whereas memory retrieval is impaired under stress ( De Quervain et al, 1998 ; Cai et al, 2006 ). Interestingly, recurrent stress across life has been shown to improve cognitive performance in individual rats ( Hadar et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Challenges and advanced concepts for the assessment of learning and memory function in mice

Lang,

Kahnau,

Hohlbaum

et al. 2023

Front. Behav. Neurosci.

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The mechanisms underlying the formation and retrieval of memories are still an active area of research and discussion. Manifold models have been proposed and refined over the years, with most assuming a dichotomy between memory processes involving non-conscious and conscious mechanisms. Despite our incomplete understanding of the underlying mechanisms, tests of memory and learning count among the most performed behavioral experiments. Here, we will discuss available protocols for testing learning and memory using the example of the most prevalent animal species in research, the laboratory mouse. A wide range of protocols has been developed in mice to test, e.g., object recognition, spatial learning, procedural memory, sequential problem solving, operant- and fear conditioning, and social recognition. Those assays are carried out with individual subjects in apparatuses such as arenas and mazes, which allow for a high degree of standardization across laboratories and straightforward data interpretation but are not without caveats and limitations. In animal research, there is growing concern about the translatability of study results and animal welfare, leading to novel approaches beyond established protocols. Here, we present some of the more recent developments and more advanced concepts in learning and memory testing, such as multi-step sequential lockboxes, assays involving groups of animals, as well as home cage-based assays supported by automated tracking solutions; and weight their potential and limitations against those of established paradigms. Shifting the focus of learning tests from the classical experimental chamber to settings which are more natural for rodents comes with a new set of challenges for behavioral researchers, but also offers the opportunity to understand memory formation and retrieval in a more conclusive way than has been attainable with conventional test protocols. We predict and embrace an increase in studies relying on methods involving a higher degree of automatization, more naturalistic- and home cage-based experimental setting as well as more integrated learning tasks in the future. We are confident these trends are suited to alleviate the burden on animal subjects and improve study designs in memory research.

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Recurrent stress across life may improve cognitive performance in individual rats, suggesting the induction of resilience

Cited by 10 publications

References 45 publications

Associations between Recurrent COVID-19, Attention, and Mental Health: A Longitudinal Study

Associations between Recurrent COVID-19, Attention, and Mental Health: A Longitudinal Study

Small RNAs: an ideal choice as sperm quality biomarkers

Challenges and advanced concepts for the assessment of learning and memory function in mice

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