Med Bull Haseki 2016;54:176-8 Introduction Stress-induced cardiomyopathy (SIC) is a non-ischemic cardiomyopathy with reversible left ventricular (LV) dysfunction which is mostly seen in post menopausal women. It is also known as takotsubo cardiomyopathy, broken heart syndrome and transient LV apical ballooning syndrome. An apparent relationship of emotional and physical stress, and adverse cardiac events, such as myocardial infarction (MI), with death has been reported (1,2). Recurrence of this disease is rarely observed. Until now, in large series, the rate of recurrence has been reported to be 2.7% (3).
CaseA 56-year-old female patient with a history of hypertension and hyperlipidemia was admitted to our emergency clinic with the complaint of chest pain just after she heard about her mother's death. Initial physical examination was normal. Electrocardiography (ECG) revealed negative T waves in precordial V1 to V6 leads ( Figure 1). The troponin I level was 2.39 µg/L (normal reference value is <0.1µg/L). In transthorasic echocardiography, the ejection fraction was 30% and LV apical and mid segments were akinetic with basal segment hyperkinesia. Coronary angiography was normal with an impaired ventriculography which showed akinetic apical and mid, and hyperkinetic basal segments (Figure 2a, 2b). A therapy with aspirin 100 mg po qd, perindopril 5 mg po qd, metoprolol 50 mg po qd with a twice daily subcutaneous injection of 0.6 cc enoxoparine was started. She was hemodynamically stable during follow-up. After four days, she was discharged on aspirin 100 mg po qd, perindopril 5 mg po qd, metoprolol 50 mg po qd. On the second week, during transthorasic echocardiography, we detected normal LV systolic functions. Her ECG and troponin level were also found to be normal.Strese bağlı kardiyomiyopati yoğun duygusal ya da fiziksel stres tarafından tetiklenen geçici kardiyak disfonksiyon sendromudur. Belirgin koroner arter hastalığı yokluğunda, spesifik ekokardiyografik bulgular ve klinik prezentasyon (göğüs ağrısı ve dispne) akut koroner sendromu taklit edebilir. Patofizyoloji sıklıkla stresin tetiklediği katekolamin salınımı ile ilişkilidir. Sendrom, çoğunlukla postmenopozal yaş grubu kadınlarda sıktır. %2'den daha az hastane içi mortalite ile prognozu iyidir. Tek epizodlu strese bağlı kardiyomiyopati literatürde yaygındır fakat tekrarlayan epizodlu olgular nadirdir. Bu sendromun doğasının daha iyi anlaşılması için bu olguyu sunduk.AnahtarSözcükler:Akut koroner sendrom, takotsubo, tekrarlayan Stress-induced cardiomyopathy or takotsubo syndrome is a transient cardiac dysfunction which is precipitated by intense emotional or physical stress. It mimics acute coronary syndrome clinically (chest pain and dyspnea) and has specific echocardiographic findings in the absence of significant coronary stenosis. The underlying pathophysiologic mechanism is mostly due to stress-induced catecholamine release. This syndrome is more commonly seen in females especially in the postmenopausal period. The prognosis of stress-induced card...